| Scientific: | Eurycoma longifolia |
|---|---|
| Other: | Tongkat Ali |
| Family: | Simaroubaceae |
Reproduction
• infertility (male)
• erectile dysfunction
• hypogonadism
Endocrine
• stress
• weight loss
• diabetes
Musculoskeletal
• osteoporosis
• athletic performance
• weight loss
• weight lifting
Infection
• dysentary
• fever
• lymphadenopathy
• parasites (malaria, toxoplasmosi )
• Male Tonic
• Phytoandrogenic
• Adaptogen
• Bitter
• Antiosteoporotic
• Antidiabetic
• Aromatase Inhbitor
• Anticancer
• Antipyretic
• Anxiolytic
• Antiinflammatory
• Anticancer
• Aromatase Inhibitor
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=> object(Cake\ORM\Entity) { 'id' => (int) 2670, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f00_web_title' => 'Tongkat Ali (Eurycoma longifolia) - Benefits & Side-Effects', 'f01_header1' => 'Eurycoma longifolia', 'f01_header2' => 'Tongkat Ali', 'f01_header3' => 'Simaroubaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => 'Simaroubaceae', 'f02_body_NHP_summary' => '', 'f02_body1' => 'Reproduction <br> • infertility (male) <br> • <a href='/conditions/erectile-dysfunction' style='text-decoration: none'>erectile dysfunction</a> <br> • hypogonadism <br> <br> Endocrine <br> • stress <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> <br> Musculoskeletal <br> • <a href='/conditions/osteoporosis' style='text-decoration: none'>osteoporosis</a> <br> • athletic performance <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • weight lifting <br> <br> Infection <br> • dysentary <br> • <a href='/conditions/fever' style='text-decoration: none'>fever</a> <br> • lymphadenopathy <br> • parasites (<a href='/conditions/malaria' style='text-decoration: none'>malaria</a>, toxoplasmosi )', 'f02_body2' => '• <a href='/actions/male-tonic' style='text-decoration: none'>Male Tonic</a> <br> • Phytoandrogenic <br> • <a href='/actions/adaptogen' style='text-decoration: none'>Adaptogen</a> <br> • Bitter <br> • Antiosteoporotic <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • Aromatase Inhbitor <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • <a href='/actions/antipyretic' style='text-decoration: none'>Antipyretic</a> <br> • <a href='/actions/anxiolytic' style='text-decoration: none'>Anxiolytic</a> <br> • <a href='/actions/antiinflammatory' style='text-decoration: none'>Antiinflammatory</a> <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • Aromatase Inhibitor', 'f02_body3' => '• Triterpenoids: Quassinoids (E.g. laurycomalactone, Eurycomalactone, Longilactone, Eurylactone, And Eurycomanone) < br > • Alkaloids (E.g. β -Carboline )', 'f02_body4' => '• increases testosterone levels via HPA axis <br> • activates 17 α -hydroxylase (CYP17 enzyme) <br> • inhibits phosphodiesterase <br> • inhibits aromatase', 'f02_body5' => '• Recommended dose has not been established <br> • Typical dose:100-600mg/day (water extract) <br> • Acceptable daily intake (ADI) = 1.2 g/adult/day', 'f02_body6' => '• Generally considered safe <br> • Side-effects: long term consumption may beassociated with sleep apnea, facial flushing, pressure in the testicles, and hyper aggressiveness (no established yet) <br> • LD50 (water extract) = > 6g/kg b.w. <br> <br> Note: in the past several products labelled as <a href='/herbals/tongkat-ali' style='text-decoration: none'>Tongkat Ali</a> have been adulterated with prescription PDE5 inhibitors (i.e. viagara) in both Canada and USA.', 'f02_body7' => '', 'f02_body8' => 'Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014:179529. doi: 10.1155/2014/179529. Epub 2014 Jan 12. PMCID: PMC3914427. <br> <br> Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia. 2012 May;44 Suppl 1:226-30. doi: 10.1111/j.1439-0272.2011.01168.x. Epub 2011 Jun 15. <br> <br> Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010 May;12(3):376-80. doi: 10.1038/aja.2010.7. Epub 2010 Mar 29. <br> <br> Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 May 26;10(1):28. doi: 10.1186/1550-2783-10-28. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23705671'>PMID: 23705671</a>; PubMed Central PMCID: PMC3669033. <br> <br> Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23243445'>PMID: 23243445</a>; PubMed Central PMCID: PMC3518798. <br> <br> Abdulghani M, Hussin AH, Sulaiman SA, Chan KL. The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats. Reprod Biol. 2012 Jul;12(2):247-55. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22850474'>PMID: 22850474</a>. <br> <br> Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat Med. 2013;2013:102987. doi: 10.1155/2013/102987. Epub 2013 Aug 25. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24062779'>PMID: 24062779</a>; PubMed Central PMCID: PMC3767077. <br> <br> Saadiah Abdul Razak H, Shuid AN, Naina Mohamed I. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evid Based Complement Alternat Med. 2012;2012:872406. doi: 10.1155/2012/872406. Epub 2012 Aug 9. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22924057'>PMID: 22924057</a>; PubMed Central PMCID: PMC3424595. <br> <br> Shuid AN, El-arabi E, Effendy NM, Razak HS, Muhammad N, Mohamed N, Soelaiman IN. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med. 2012 Sep 12;12:152. doi: 10.1186/1472-6882-12-152. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22967165'>PMID: 22967165</a>; PubMed Central PMCID: PMC3493384. <br> <br> Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79. doi: 10.1016/j.fitote.2010.04.006. Epub 2010 Apr 29. Review. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/20434529'>PMID: 20434529</a>. <br> <br> Farouk AE, Benafri A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J. 2007 Sep;28(9):1422-4. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/17768473'>PMID: 17768473</a>. <br> <br> Nurhanan MY, Azimahtol Hawariah LP, Mohd Ilham A, Mohd Shukri MA. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res. 2005 Nov;19(11):994-6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/16317660'>PMID: 16317660</a>. <br> <br> Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol. 2004 Jun;92(2-3):223-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/15138004'>PMID: 15138004</a>. <br> <br> Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1301-3. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14600377'>PMID: 14600377</a>. <br> <br> Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 2003 Oct;66(10):1324-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14575431'>PMID: 14575431</a>. <br> <br> Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999 Apr;79(4):497-500. 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reached]], '[repository]' => 'Record' }, (int) 159 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Thyme', 'f00_web_header2' => 'Thymus vulgaris', 'f01_header1' => 'Thymus vulgaris', 'f01_header2' => 'Thyme', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/thyme', 'zkp_ID_t' => 'RECND318', 'zkp_recordID_cn' => '826498', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/thyme', 'f99_hidden' => '/herbals/thyme', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 160 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f01_header1' => 'Eurycoma longifolia', 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'https://www.nhpassist.com/herbals/turmeric', 'f99_hidden' => '/herbals/turmeric', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 162 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Valerian', 'f00_web_header2' => 'Valeriana officinalis', 'f01_header1' => 'Valeriana officinalis', 'f01_header2' => 'Valerian', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/valerian', 'zkp_ID_t' => 'RECND321', 'zkp_recordID_cn' => '826501', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/valerian', 'f99_hidden' => '/herbals/valerian', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum 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object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wild Indigo', 'f00_web_header2' => 'Baptisia tinctoria', 'f01_header1' => 'Baptisia tinctoria', 'f01_header2' => 'Wild Indigo', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wild-indigo', 'zkp_ID_t' => 'RECND327', 'zkp_recordID_cn' => '826507', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wild-indigo', 'f99_hidden' => '/herbals/wild-indigo', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 165 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wild Yam', 'f00_web_header2' => 'Dioscorea villosa', 'f01_header1' => 'Dioscorea villosa', 'f01_header2' => 'Wild Yam', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wild-yam', 'zkp_ID_t' => 'RECND386', 'zkp_recordID_cn' => '826566', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wild-yam', 'f99_hidden' => '/herbals/wild-yam', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 166 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wintergreen', 'f00_web_header2' => 'Gaultheria procumbens', 'f01_header1' => 'Gaultheria procumbens', 'f01_header2' => 'Wintergreen', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wintergreen', 'zkp_ID_t' => 'RECND397', 'zkp_recordID_cn' => '826577', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wintergreen', 'f99_hidden' => '/herbals/wintergreen', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 167 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Witch hazel', 'f00_web_header2' => 'Hamamelis virginiana', 'f01_header1' => 'Hamamelis virginiana', 'f01_header2' => 'Witch hazel', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/witch-hazel', 'zkp_ID_t' => 'RECND323', 'zkp_recordID_cn' => '826503', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/witch-hazel', 'f99_hidden' => '/herbals/witch-hazel', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 168 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wormwood', 'f00_web_header2' => 'Artemisia absinthium', 'f01_header1' => 'Artemisia absinthium', 'f01_header2' => 'Wormwood', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wormwood', 'zkp_ID_t' => 'RECND354', 'zkp_recordID_cn' => '826534', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wormwood', 'f99_hidden' => '/herbals/wormwood', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 169 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Yarrow', 'f00_web_header2' => 'Achillea millefolium', 'f01_header1' => 'Achillea millefolium', 'f01_header2' => 'Yarrow', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/yarrow', 'zkp_ID_t' => 'RECND324', 'zkp_recordID_cn' => '826504', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/yarrow', 'f99_hidden' => '/herbals/yarrow', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 170 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Yellow Dock', 'f00_web_header2' => 'Rumex crispus', 'f01_header1' => 'Rumex crispus', 'f01_header2' => 'Yellow Dock', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/yellow-dock', 'zkp_ID_t' => 'RECND363', 'zkp_recordID_cn' => '826543', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/yellow-dock', 'f99_hidden' => '/herbals/yellow-dock', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' } ] $clipboard = false $keyword_products = [] $url_id = [ (int) 0 => object(Cake\ORM\Entity) { 'label' => 'PubMed?', 'location' => '', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' }, (int) 1 => object(Cake\ORM\Entity) { 'label' => 'Wikipedia', 'location' => 'http://en.wikipedia.org/wiki/Eurycoma_longifolia', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' } ] $pubmed_keyword = 'Eurycoma longifolia' $pubmed_array = [ (int) 0 => '23705671', (int) 1 => '23243445', (int) 2 => '22850474', (int) 3 => '24062779', (int) 4 => '22924057', (int) 5 => '22967165', (int) 6 => '20434529', (int) 7 => '17768473', (int) 8 => '16317660', (int) 9 => '15138004', (int) 10 => '14600377', (int) 11 => '14575431', (int) 12 => '10361892' ] $record = object(Cake\ORM\Entity) { 'id' => (int) 2670, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f00_web_title' => 'Tongkat Ali (Eurycoma longifolia) - Benefits & Side-Effects', 'f01_header1' => 'Eurycoma longifolia', 'f01_header2' => 'Tongkat Ali', 'f01_header3' => 'Simaroubaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => 'Simaroubaceae', 'f02_body_NHP_summary' => '', 'f02_body1' => 'Reproduction <br> • infertility (male) <br> • <a href='/conditions/erectile-dysfunction' style='text-decoration: none'>erectile dysfunction</a> <br> • hypogonadism <br> <br> Endocrine <br> • stress <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> <br> Musculoskeletal <br> • <a href='/conditions/osteoporosis' style='text-decoration: none'>osteoporosis</a> <br> • athletic performance <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • weight lifting <br> <br> Infection <br> • dysentary <br> • <a href='/conditions/fever' style='text-decoration: none'>fever</a> <br> • lymphadenopathy <br> • parasites (<a href='/conditions/malaria' style='text-decoration: none'>malaria</a>, toxoplasmosi )', 'f02_body2' => '• <a href='/actions/male-tonic' style='text-decoration: none'>Male Tonic</a> <br> • Phytoandrogenic <br> • <a href='/actions/adaptogen' style='text-decoration: none'>Adaptogen</a> <br> • Bitter <br> • Antiosteoporotic <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • Aromatase Inhbitor <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • <a href='/actions/antipyretic' style='text-decoration: none'>Antipyretic</a> <br> • <a href='/actions/anxiolytic' style='text-decoration: none'>Anxiolytic</a> <br> • <a href='/actions/antiinflammatory' style='text-decoration: none'>Antiinflammatory</a> <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • Aromatase Inhibitor', 'f02_body3' => '• Triterpenoids: Quassinoids (E.g. laurycomalactone, Eurycomalactone, Longilactone, Eurylactone, And Eurycomanone) < br > • Alkaloids (E.g. β -Carboline )', 'f02_body4' => '• increases testosterone levels via HPA axis <br> • activates 17 α -hydroxylase (CYP17 enzyme) <br> • inhibits phosphodiesterase <br> • inhibits aromatase', 'f02_body5' => '• Recommended dose has not been established <br> • Typical dose:100-600mg/day (water extract) <br> • Acceptable daily intake (ADI) = 1.2 g/adult/day', 'f02_body6' => '• Generally considered safe <br> • Side-effects: long term consumption may beassociated with sleep apnea, facial flushing, pressure in the testicles, and hyper aggressiveness (no established yet) <br> • LD50 (water extract) = > 6g/kg b.w. <br> <br> Note: in the past several products labelled as <a href='/herbals/tongkat-ali' style='text-decoration: none'>Tongkat Ali</a> have been adulterated with prescription PDE5 inhibitors (i.e. viagara) in both Canada and USA.', 'f02_body7' => '', 'f02_body8' => 'Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014:179529. doi: 10.1155/2014/179529. Epub 2014 Jan 12. PMCID: PMC3914427. <br> <br> Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia. 2012 May;44 Suppl 1:226-30. doi: 10.1111/j.1439-0272.2011.01168.x. Epub 2011 Jun 15. <br> <br> Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010 May;12(3):376-80. doi: 10.1038/aja.2010.7. Epub 2010 Mar 29. <br> <br> Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 May 26;10(1):28. doi: 10.1186/1550-2783-10-28. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23705671'>PMID: 23705671</a>; PubMed Central PMCID: PMC3669033. <br> <br> Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23243445'>PMID: 23243445</a>; PubMed Central PMCID: PMC3518798. <br> <br> Abdulghani M, Hussin AH, Sulaiman SA, Chan KL. The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats. Reprod Biol. 2012 Jul;12(2):247-55. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22850474'>PMID: 22850474</a>. <br> <br> Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat Med. 2013;2013:102987. doi: 10.1155/2013/102987. Epub 2013 Aug 25. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24062779'>PMID: 24062779</a>; PubMed Central PMCID: PMC3767077. <br> <br> Saadiah Abdul Razak H, Shuid AN, Naina Mohamed I. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evid Based Complement Alternat Med. 2012;2012:872406. doi: 10.1155/2012/872406. Epub 2012 Aug 9. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22924057'>PMID: 22924057</a>; PubMed Central PMCID: PMC3424595. <br> <br> Shuid AN, El-arabi E, Effendy NM, Razak HS, Muhammad N, Mohamed N, Soelaiman IN. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med. 2012 Sep 12;12:152. doi: 10.1186/1472-6882-12-152. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22967165'>PMID: 22967165</a>; PubMed Central PMCID: PMC3493384. <br> <br> Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79. doi: 10.1016/j.fitote.2010.04.006. Epub 2010 Apr 29. Review. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/20434529'>PMID: 20434529</a>. <br> <br> Farouk AE, Benafri A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J. 2007 Sep;28(9):1422-4. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/17768473'>PMID: 17768473</a>. <br> <br> Nurhanan MY, Azimahtol Hawariah LP, Mohd Ilham A, Mohd Shukri MA. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res. 2005 Nov;19(11):994-6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/16317660'>PMID: 16317660</a>. <br> <br> Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol. 2004 Jun;92(2-3):223-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/15138004'>PMID: 15138004</a>. <br> <br> Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1301-3. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14600377'>PMID: 14600377</a>. <br> <br> Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 2003 Oct;66(10):1324-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14575431'>PMID: 14575431</a>. <br> <br> Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999 Apr;79(4):497-500. 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'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f00_web_title' => 'Tongkat Ali (Eurycoma longifolia) - Benefits & Side-Effects', 'f01_header1' => 'Eurycoma longifolia', 'f01_header2' => 'Tongkat Ali', 'f01_header3' => 'Simaroubaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => 'Simaroubaceae', 'f02_body_NHP_summary' => '', 'f02_body1' => 'Reproduction <br> • infertility (male) <br> • <a href='/conditions/erectile-dysfunction' style='text-decoration: none'>erectile dysfunction</a> <br> • hypogonadism <br> <br> Endocrine <br> • stress <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> <br> Musculoskeletal <br> • <a href='/conditions/osteoporosis' style='text-decoration: none'>osteoporosis</a> <br> • athletic performance <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • weight lifting <br> <br> Infection <br> • dysentary <br> • <a href='/conditions/fever' style='text-decoration: none'>fever</a> <br> • lymphadenopathy <br> • parasites (<a href='/conditions/malaria' style='text-decoration: none'>malaria</a>, toxoplasmosi )', 'f02_body2' => '• <a href='/actions/male-tonic' style='text-decoration: none'>Male Tonic</a> <br> • Phytoandrogenic <br> • <a href='/actions/adaptogen' style='text-decoration: none'>Adaptogen</a> <br> • Bitter <br> • Antiosteoporotic <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • Aromatase Inhbitor <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • <a href='/actions/antipyretic' style='text-decoration: none'>Antipyretic</a> <br> • <a href='/actions/anxiolytic' style='text-decoration: none'>Anxiolytic</a> <br> • <a href='/actions/antiinflammatory' style='text-decoration: none'>Antiinflammatory</a> <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • Aromatase Inhibitor', 'f02_body3' => '• Triterpenoids: Quassinoids (E.g. laurycomalactone, Eurycomalactone, Longilactone, Eurylactone, And Eurycomanone) < br > • Alkaloids (E.g. β -Carboline )', 'f02_body4' => '• increases testosterone levels via HPA axis <br> • activates 17 α -hydroxylase (CYP17 enzyme) <br> • inhibits phosphodiesterase <br> • inhibits aromatase', 'f02_body5' => '• Recommended dose has not been established <br> • Typical dose:100-600mg/day (water extract) <br> • Acceptable daily intake (ADI) = 1.2 g/adult/day', 'f02_body6' => '• Generally considered safe <br> • Side-effects: long term consumption may beassociated with sleep apnea, facial flushing, pressure in the testicles, and hyper aggressiveness (no established yet) <br> • LD50 (water extract) = > 6g/kg b.w. <br> <br> Note: in the past several products labelled as <a href='/herbals/tongkat-ali' style='text-decoration: none'>Tongkat Ali</a> have been adulterated with prescription PDE5 inhibitors (i.e. viagara) in both Canada and USA.', 'f02_body7' => '', 'f02_body8' => 'Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014:179529. doi: 10.1155/2014/179529. Epub 2014 Jan 12. PMCID: PMC3914427. <br> <br> Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia. 2012 May;44 Suppl 1:226-30. doi: 10.1111/j.1439-0272.2011.01168.x. Epub 2011 Jun 15. <br> <br> Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010 May;12(3):376-80. doi: 10.1038/aja.2010.7. Epub 2010 Mar 29. <br> <br> Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 May 26;10(1):28. doi: 10.1186/1550-2783-10-28. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23705671'>PMID: 23705671</a>; PubMed Central PMCID: PMC3669033. <br> <br> Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23243445'>PMID: 23243445</a>; PubMed Central PMCID: PMC3518798. <br> <br> Abdulghani M, Hussin AH, Sulaiman SA, Chan KL. The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats. Reprod Biol. 2012 Jul;12(2):247-55. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22850474'>PMID: 22850474</a>. <br> <br> Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat Med. 2013;2013:102987. doi: 10.1155/2013/102987. Epub 2013 Aug 25. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24062779'>PMID: 24062779</a>; PubMed Central PMCID: PMC3767077. <br> <br> Saadiah Abdul Razak H, Shuid AN, Naina Mohamed I. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evid Based Complement Alternat Med. 2012;2012:872406. doi: 10.1155/2012/872406. Epub 2012 Aug 9. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22924057'>PMID: 22924057</a>; PubMed Central PMCID: PMC3424595. <br> <br> Shuid AN, El-arabi E, Effendy NM, Razak HS, Muhammad N, Mohamed N, Soelaiman IN. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med. 2012 Sep 12;12:152. doi: 10.1186/1472-6882-12-152. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22967165'>PMID: 22967165</a>; PubMed Central PMCID: PMC3493384. <br> <br> Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79. doi: 10.1016/j.fitote.2010.04.006. Epub 2010 Apr 29. Review. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/20434529'>PMID: 20434529</a>. <br> <br> Farouk AE, Benafri A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J. 2007 Sep;28(9):1422-4. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/17768473'>PMID: 17768473</a>. <br> <br> Nurhanan MY, Azimahtol Hawariah LP, Mohd Ilham A, Mohd Shukri MA. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res. 2005 Nov;19(11):994-6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/16317660'>PMID: 16317660</a>. <br> <br> Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol. 2004 Jun;92(2-3):223-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/15138004'>PMID: 15138004</a>. <br> <br> Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1301-3. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14600377'>PMID: 14600377</a>. <br> <br> Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 2003 Oct;66(10):1324-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14575431'>PMID: 14575431</a>. <br> <br> Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999 Apr;79(4):497-500. 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reached]], '[repository]' => 'Record' }, (int) 159 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Thyme', 'f00_web_header2' => 'Thymus vulgaris', 'f01_header1' => 'Thymus vulgaris', 'f01_header2' => 'Thyme', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/thyme', 'zkp_ID_t' => 'RECND318', 'zkp_recordID_cn' => '826498', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/thyme', 'f99_hidden' => '/herbals/thyme', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 160 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f01_header1' => 'Eurycoma longifolia', 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'https://www.nhpassist.com/herbals/turmeric', 'f99_hidden' => '/herbals/turmeric', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 162 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Valerian', 'f00_web_header2' => 'Valeriana officinalis', 'f01_header1' => 'Valeriana officinalis', 'f01_header2' => 'Valerian', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/valerian', 'zkp_ID_t' => 'RECND321', 'zkp_recordID_cn' => '826501', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/valerian', 'f99_hidden' => '/herbals/valerian', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum 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object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wild Indigo', 'f00_web_header2' => 'Baptisia tinctoria', 'f01_header1' => 'Baptisia tinctoria', 'f01_header2' => 'Wild Indigo', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wild-indigo', 'zkp_ID_t' => 'RECND327', 'zkp_recordID_cn' => '826507', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wild-indigo', 'f99_hidden' => '/herbals/wild-indigo', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 165 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wild Yam', 'f00_web_header2' => 'Dioscorea villosa', 'f01_header1' => 'Dioscorea villosa', 'f01_header2' => 'Wild Yam', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wild-yam', 'zkp_ID_t' => 'RECND386', 'zkp_recordID_cn' => '826566', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wild-yam', 'f99_hidden' => '/herbals/wild-yam', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 166 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wintergreen', 'f00_web_header2' => 'Gaultheria procumbens', 'f01_header1' => 'Gaultheria procumbens', 'f01_header2' => 'Wintergreen', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wintergreen', 'zkp_ID_t' => 'RECND397', 'zkp_recordID_cn' => '826577', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wintergreen', 'f99_hidden' => '/herbals/wintergreen', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 167 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Witch hazel', 'f00_web_header2' => 'Hamamelis virginiana', 'f01_header1' => 'Hamamelis virginiana', 'f01_header2' => 'Witch hazel', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/witch-hazel', 'zkp_ID_t' => 'RECND323', 'zkp_recordID_cn' => '826503', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/witch-hazel', 'f99_hidden' => '/herbals/witch-hazel', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 168 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wormwood', 'f00_web_header2' => 'Artemisia absinthium', 'f01_header1' => 'Artemisia absinthium', 'f01_header2' => 'Wormwood', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wormwood', 'zkp_ID_t' => 'RECND354', 'zkp_recordID_cn' => '826534', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wormwood', 'f99_hidden' => '/herbals/wormwood', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 169 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Yarrow', 'f00_web_header2' => 'Achillea millefolium', 'f01_header1' => 'Achillea millefolium', 'f01_header2' => 'Yarrow', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/yarrow', 'zkp_ID_t' => 'RECND324', 'zkp_recordID_cn' => '826504', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/yarrow', 'f99_hidden' => '/herbals/yarrow', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 170 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Yellow Dock', 'f00_web_header2' => 'Rumex crispus', 'f01_header1' => 'Rumex crispus', 'f01_header2' => 'Yellow Dock', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/yellow-dock', 'zkp_ID_t' => 'RECND363', 'zkp_recordID_cn' => '826543', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/yellow-dock', 'f99_hidden' => '/herbals/yellow-dock', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' } ] $clipboard = false $keyword_products = [] $url_id = [ (int) 0 => object(Cake\ORM\Entity) { 'label' => 'PubMed?', 'location' => '', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' }, (int) 1 => object(Cake\ORM\Entity) { 'label' => 'Wikipedia', 'location' => 'http://en.wikipedia.org/wiki/Eurycoma_longifolia', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' } ] $pubmed_keyword = 'Eurycoma longifolia' $pubmed_array = [ (int) 0 => '23705671', (int) 1 => '23243445', (int) 2 => '22850474', (int) 3 => '24062779', (int) 4 => '22924057', (int) 5 => '22967165', (int) 6 => '20434529', (int) 7 => '17768473', (int) 8 => '16317660', (int) 9 => '15138004', (int) 10 => '14600377', (int) 11 => '14575431', (int) 12 => '10361892' ] $record = object(Cake\ORM\Entity) { 'id' => (int) 2670, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f00_web_title' => 'Tongkat Ali (Eurycoma longifolia) - Benefits & Side-Effects', 'f01_header1' => 'Eurycoma longifolia', 'f01_header2' => 'Tongkat Ali', 'f01_header3' => 'Simaroubaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => 'Simaroubaceae', 'f02_body_NHP_summary' => '', 'f02_body1' => 'Reproduction <br> • infertility (male) <br> • <a href='/conditions/erectile-dysfunction' style='text-decoration: none'>erectile dysfunction</a> <br> • hypogonadism <br> <br> Endocrine <br> • stress <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> <br> Musculoskeletal <br> • <a href='/conditions/osteoporosis' style='text-decoration: none'>osteoporosis</a> <br> • athletic performance <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • weight lifting <br> <br> Infection <br> • dysentary <br> • <a href='/conditions/fever' style='text-decoration: none'>fever</a> <br> • lymphadenopathy <br> • parasites (<a href='/conditions/malaria' style='text-decoration: none'>malaria</a>, toxoplasmosi )', 'f02_body2' => '• <a href='/actions/male-tonic' style='text-decoration: none'>Male Tonic</a> <br> • Phytoandrogenic <br> • <a href='/actions/adaptogen' style='text-decoration: none'>Adaptogen</a> <br> • Bitter <br> • Antiosteoporotic <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • Aromatase Inhbitor <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • <a href='/actions/antipyretic' style='text-decoration: none'>Antipyretic</a> <br> • <a href='/actions/anxiolytic' style='text-decoration: none'>Anxiolytic</a> <br> • <a href='/actions/antiinflammatory' style='text-decoration: none'>Antiinflammatory</a> <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • Aromatase Inhibitor', 'f02_body3' => '• Triterpenoids: Quassinoids (E.g. laurycomalactone, Eurycomalactone, Longilactone, Eurylactone, And Eurycomanone) < br > • Alkaloids (E.g. β -Carboline )', 'f02_body4' => '• increases testosterone levels via HPA axis <br> • activates 17 α -hydroxylase (CYP17 enzyme) <br> • inhibits phosphodiesterase <br> • inhibits aromatase', 'f02_body5' => '• Recommended dose has not been established <br> • Typical dose:100-600mg/day (water extract) <br> • Acceptable daily intake (ADI) = 1.2 g/adult/day', 'f02_body6' => '• Generally considered safe <br> • Side-effects: long term consumption may beassociated with sleep apnea, facial flushing, pressure in the testicles, and hyper aggressiveness (no established yet) <br> • LD50 (water extract) = > 6g/kg b.w. <br> <br> Note: in the past several products labelled as <a href='/herbals/tongkat-ali' style='text-decoration: none'>Tongkat Ali</a> have been adulterated with prescription PDE5 inhibitors (i.e. viagara) in both Canada and USA.', 'f02_body7' => '', 'f02_body8' => 'Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014:179529. doi: 10.1155/2014/179529. Epub 2014 Jan 12. PMCID: PMC3914427. <br> <br> Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia. 2012 May;44 Suppl 1:226-30. doi: 10.1111/j.1439-0272.2011.01168.x. Epub 2011 Jun 15. <br> <br> Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010 May;12(3):376-80. doi: 10.1038/aja.2010.7. Epub 2010 Mar 29. <br> <br> Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 May 26;10(1):28. doi: 10.1186/1550-2783-10-28. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23705671'>PMID: 23705671</a>; PubMed Central PMCID: PMC3669033. <br> <br> Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23243445'>PMID: 23243445</a>; PubMed Central PMCID: PMC3518798. <br> <br> Abdulghani M, Hussin AH, Sulaiman SA, Chan KL. The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats. Reprod Biol. 2012 Jul;12(2):247-55. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22850474'>PMID: 22850474</a>. <br> <br> Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat Med. 2013;2013:102987. doi: 10.1155/2013/102987. Epub 2013 Aug 25. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24062779'>PMID: 24062779</a>; PubMed Central PMCID: PMC3767077. <br> <br> Saadiah Abdul Razak H, Shuid AN, Naina Mohamed I. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evid Based Complement Alternat Med. 2012;2012:872406. doi: 10.1155/2012/872406. Epub 2012 Aug 9. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22924057'>PMID: 22924057</a>; PubMed Central PMCID: PMC3424595. <br> <br> Shuid AN, El-arabi E, Effendy NM, Razak HS, Muhammad N, Mohamed N, Soelaiman IN. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med. 2012 Sep 12;12:152. doi: 10.1186/1472-6882-12-152. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22967165'>PMID: 22967165</a>; PubMed Central PMCID: PMC3493384. <br> <br> Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79. doi: 10.1016/j.fitote.2010.04.006. Epub 2010 Apr 29. Review. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/20434529'>PMID: 20434529</a>. <br> <br> Farouk AE, Benafri A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J. 2007 Sep;28(9):1422-4. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/17768473'>PMID: 17768473</a>. <br> <br> Nurhanan MY, Azimahtol Hawariah LP, Mohd Ilham A, Mohd Shukri MA. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res. 2005 Nov;19(11):994-6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/16317660'>PMID: 16317660</a>. <br> <br> Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol. 2004 Jun;92(2-3):223-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/15138004'>PMID: 15138004</a>. <br> <br> Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1301-3. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14600377'>PMID: 14600377</a>. <br> <br> Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 2003 Oct;66(10):1324-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14575431'>PMID: 14575431</a>. <br> <br> Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999 Apr;79(4):497-500. 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• Triterpenoids: Quassinoids (E.g. laurycomalactone, Eurycomalactone, Longilactone, Eurylactone, And Eurycomanone) < br > • Alkaloids (E.g. β -Carboline )
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'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f00_web_title' => 'Tongkat Ali (Eurycoma longifolia) - Benefits & Side-Effects', 'f01_header1' => 'Eurycoma longifolia', 'f01_header2' => 'Tongkat Ali', 'f01_header3' => 'Simaroubaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => 'Simaroubaceae', 'f02_body_NHP_summary' => '', 'f02_body1' => 'Reproduction <br> • infertility (male) <br> • <a href='/conditions/erectile-dysfunction' style='text-decoration: none'>erectile dysfunction</a> <br> • hypogonadism <br> <br> Endocrine <br> • stress <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> <br> Musculoskeletal <br> • <a href='/conditions/osteoporosis' style='text-decoration: none'>osteoporosis</a> <br> • athletic performance <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • weight lifting <br> <br> Infection <br> • dysentary <br> • <a href='/conditions/fever' style='text-decoration: none'>fever</a> <br> • lymphadenopathy <br> • parasites (<a href='/conditions/malaria' style='text-decoration: none'>malaria</a>, toxoplasmosi )', 'f02_body2' => '• <a href='/actions/male-tonic' style='text-decoration: none'>Male Tonic</a> <br> • Phytoandrogenic <br> • <a href='/actions/adaptogen' style='text-decoration: none'>Adaptogen</a> <br> • Bitter <br> • Antiosteoporotic <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • Aromatase Inhbitor <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • <a href='/actions/antipyretic' style='text-decoration: none'>Antipyretic</a> <br> • <a href='/actions/anxiolytic' style='text-decoration: none'>Anxiolytic</a> <br> • <a href='/actions/antiinflammatory' style='text-decoration: none'>Antiinflammatory</a> <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • Aromatase Inhibitor', 'f02_body3' => '• Triterpenoids: Quassinoids (E.g. laurycomalactone, Eurycomalactone, Longilactone, Eurylactone, And Eurycomanone) < br > • Alkaloids (E.g. β -Carboline )', 'f02_body4' => '• increases testosterone levels via HPA axis <br> • activates 17 α -hydroxylase (CYP17 enzyme) <br> • inhibits phosphodiesterase <br> • inhibits aromatase', 'f02_body5' => '• Recommended dose has not been established <br> • Typical dose:100-600mg/day (water extract) <br> • Acceptable daily intake (ADI) = 1.2 g/adult/day', 'f02_body6' => '• Generally considered safe <br> • Side-effects: long term consumption may beassociated with sleep apnea, facial flushing, pressure in the testicles, and hyper aggressiveness (no established yet) <br> • LD50 (water extract) = > 6g/kg b.w. <br> <br> Note: in the past several products labelled as <a href='/herbals/tongkat-ali' style='text-decoration: none'>Tongkat Ali</a> have been adulterated with prescription PDE5 inhibitors (i.e. viagara) in both Canada and USA.', 'f02_body7' => '', 'f02_body8' => 'Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014:179529. doi: 10.1155/2014/179529. Epub 2014 Jan 12. PMCID: PMC3914427. <br> <br> Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia. 2012 May;44 Suppl 1:226-30. doi: 10.1111/j.1439-0272.2011.01168.x. Epub 2011 Jun 15. <br> <br> Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010 May;12(3):376-80. doi: 10.1038/aja.2010.7. Epub 2010 Mar 29. <br> <br> Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 May 26;10(1):28. doi: 10.1186/1550-2783-10-28. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23705671'>PMID: 23705671</a>; PubMed Central PMCID: PMC3669033. <br> <br> Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23243445'>PMID: 23243445</a>; PubMed Central PMCID: PMC3518798. <br> <br> Abdulghani M, Hussin AH, Sulaiman SA, Chan KL. The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats. Reprod Biol. 2012 Jul;12(2):247-55. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22850474'>PMID: 22850474</a>. <br> <br> Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat Med. 2013;2013:102987. doi: 10.1155/2013/102987. Epub 2013 Aug 25. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24062779'>PMID: 24062779</a>; PubMed Central PMCID: PMC3767077. <br> <br> Saadiah Abdul Razak H, Shuid AN, Naina Mohamed I. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evid Based Complement Alternat Med. 2012;2012:872406. doi: 10.1155/2012/872406. Epub 2012 Aug 9. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22924057'>PMID: 22924057</a>; PubMed Central PMCID: PMC3424595. <br> <br> Shuid AN, El-arabi E, Effendy NM, Razak HS, Muhammad N, Mohamed N, Soelaiman IN. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med. 2012 Sep 12;12:152. doi: 10.1186/1472-6882-12-152. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22967165'>PMID: 22967165</a>; PubMed Central PMCID: PMC3493384. <br> <br> Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79. doi: 10.1016/j.fitote.2010.04.006. Epub 2010 Apr 29. Review. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/20434529'>PMID: 20434529</a>. <br> <br> Farouk AE, Benafri A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J. 2007 Sep;28(9):1422-4. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/17768473'>PMID: 17768473</a>. <br> <br> Nurhanan MY, Azimahtol Hawariah LP, Mohd Ilham A, Mohd Shukri MA. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res. 2005 Nov;19(11):994-6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/16317660'>PMID: 16317660</a>. <br> <br> Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol. 2004 Jun;92(2-3):223-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/15138004'>PMID: 15138004</a>. <br> <br> Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1301-3. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14600377'>PMID: 14600377</a>. <br> <br> Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 2003 Oct;66(10):1324-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14575431'>PMID: 14575431</a>. <br> <br> Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999 Apr;79(4):497-500. 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reached]], '[repository]' => 'Record' }, (int) 159 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Thyme', 'f00_web_header2' => 'Thymus vulgaris', 'f01_header1' => 'Thymus vulgaris', 'f01_header2' => 'Thyme', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/thyme', 'zkp_ID_t' => 'RECND318', 'zkp_recordID_cn' => '826498', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/thyme', 'f99_hidden' => '/herbals/thyme', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 160 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f01_header1' => 'Eurycoma longifolia', 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'https://www.nhpassist.com/herbals/turmeric', 'f99_hidden' => '/herbals/turmeric', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 162 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Valerian', 'f00_web_header2' => 'Valeriana officinalis', 'f01_header1' => 'Valeriana officinalis', 'f01_header2' => 'Valerian', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/valerian', 'zkp_ID_t' => 'RECND321', 'zkp_recordID_cn' => '826501', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/valerian', 'f99_hidden' => '/herbals/valerian', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum 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object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wild Indigo', 'f00_web_header2' => 'Baptisia tinctoria', 'f01_header1' => 'Baptisia tinctoria', 'f01_header2' => 'Wild Indigo', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wild-indigo', 'zkp_ID_t' => 'RECND327', 'zkp_recordID_cn' => '826507', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wild-indigo', 'f99_hidden' => '/herbals/wild-indigo', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 165 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wild Yam', 'f00_web_header2' => 'Dioscorea villosa', 'f01_header1' => 'Dioscorea villosa', 'f01_header2' => 'Wild Yam', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wild-yam', 'zkp_ID_t' => 'RECND386', 'zkp_recordID_cn' => '826566', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wild-yam', 'f99_hidden' => '/herbals/wild-yam', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 166 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wintergreen', 'f00_web_header2' => 'Gaultheria procumbens', 'f01_header1' => 'Gaultheria procumbens', 'f01_header2' => 'Wintergreen', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wintergreen', 'zkp_ID_t' => 'RECND397', 'zkp_recordID_cn' => '826577', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wintergreen', 'f99_hidden' => '/herbals/wintergreen', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 167 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Witch hazel', 'f00_web_header2' => 'Hamamelis virginiana', 'f01_header1' => 'Hamamelis virginiana', 'f01_header2' => 'Witch hazel', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/witch-hazel', 'zkp_ID_t' => 'RECND323', 'zkp_recordID_cn' => '826503', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/witch-hazel', 'f99_hidden' => '/herbals/witch-hazel', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 168 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wormwood', 'f00_web_header2' => 'Artemisia absinthium', 'f01_header1' => 'Artemisia absinthium', 'f01_header2' => 'Wormwood', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wormwood', 'zkp_ID_t' => 'RECND354', 'zkp_recordID_cn' => '826534', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wormwood', 'f99_hidden' => '/herbals/wormwood', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 169 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Yarrow', 'f00_web_header2' => 'Achillea millefolium', 'f01_header1' => 'Achillea millefolium', 'f01_header2' => 'Yarrow', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/yarrow', 'zkp_ID_t' => 'RECND324', 'zkp_recordID_cn' => '826504', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/yarrow', 'f99_hidden' => '/herbals/yarrow', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 170 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Yellow Dock', 'f00_web_header2' => 'Rumex crispus', 'f01_header1' => 'Rumex crispus', 'f01_header2' => 'Yellow Dock', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/yellow-dock', 'zkp_ID_t' => 'RECND363', 'zkp_recordID_cn' => '826543', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/yellow-dock', 'f99_hidden' => '/herbals/yellow-dock', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' } ] $clipboard = false $keyword_products = [] $url_id = [ (int) 0 => object(Cake\ORM\Entity) { 'label' => 'PubMed?', 'location' => '', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' }, (int) 1 => object(Cake\ORM\Entity) { 'label' => 'Wikipedia', 'location' => 'http://en.wikipedia.org/wiki/Eurycoma_longifolia', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' } ] $pubmed_keyword = 'Eurycoma longifolia' $pubmed_array = [ (int) 0 => '23705671', (int) 1 => '23243445', (int) 2 => '22850474', (int) 3 => '24062779', (int) 4 => '22924057', (int) 5 => '22967165', (int) 6 => '20434529', (int) 7 => '17768473', (int) 8 => '16317660', (int) 9 => '15138004', (int) 10 => '14600377', (int) 11 => '14575431', (int) 12 => '10361892' ] $record = object(Cake\ORM\Entity) { 'id' => (int) 2670, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f00_web_title' => 'Tongkat Ali (Eurycoma longifolia) - Benefits & Side-Effects', 'f01_header1' => 'Eurycoma longifolia', 'f01_header2' => 'Tongkat Ali', 'f01_header3' => 'Simaroubaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => 'Simaroubaceae', 'f02_body_NHP_summary' => '', 'f02_body1' => 'Reproduction <br> • infertility (male) <br> • <a href='/conditions/erectile-dysfunction' style='text-decoration: none'>erectile dysfunction</a> <br> • hypogonadism <br> <br> Endocrine <br> • stress <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> <br> Musculoskeletal <br> • <a href='/conditions/osteoporosis' style='text-decoration: none'>osteoporosis</a> <br> • athletic performance <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • weight lifting <br> <br> Infection <br> • dysentary <br> • <a href='/conditions/fever' style='text-decoration: none'>fever</a> <br> • lymphadenopathy <br> • parasites (<a href='/conditions/malaria' style='text-decoration: none'>malaria</a>, toxoplasmosi )', 'f02_body2' => '• <a href='/actions/male-tonic' style='text-decoration: none'>Male Tonic</a> <br> • Phytoandrogenic <br> • <a href='/actions/adaptogen' style='text-decoration: none'>Adaptogen</a> <br> • Bitter <br> • Antiosteoporotic <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • Aromatase Inhbitor <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • <a href='/actions/antipyretic' style='text-decoration: none'>Antipyretic</a> <br> • <a href='/actions/anxiolytic' style='text-decoration: none'>Anxiolytic</a> <br> • <a href='/actions/antiinflammatory' style='text-decoration: none'>Antiinflammatory</a> <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • Aromatase Inhibitor', 'f02_body3' => '• Triterpenoids: Quassinoids (E.g. laurycomalactone, Eurycomalactone, Longilactone, Eurylactone, And Eurycomanone) < br > • Alkaloids (E.g. β -Carboline )', 'f02_body4' => '• increases testosterone levels via HPA axis <br> • activates 17 α -hydroxylase (CYP17 enzyme) <br> • inhibits phosphodiesterase <br> • inhibits aromatase', 'f02_body5' => '• Recommended dose has not been established <br> • Typical dose:100-600mg/day (water extract) <br> • Acceptable daily intake (ADI) = 1.2 g/adult/day', 'f02_body6' => '• Generally considered safe <br> • Side-effects: long term consumption may beassociated with sleep apnea, facial flushing, pressure in the testicles, and hyper aggressiveness (no established yet) <br> • LD50 (water extract) = > 6g/kg b.w. <br> <br> Note: in the past several products labelled as <a href='/herbals/tongkat-ali' style='text-decoration: none'>Tongkat Ali</a> have been adulterated with prescription PDE5 inhibitors (i.e. viagara) in both Canada and USA.', 'f02_body7' => '', 'f02_body8' => 'Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014:179529. doi: 10.1155/2014/179529. Epub 2014 Jan 12. PMCID: PMC3914427. <br> <br> Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia. 2012 May;44 Suppl 1:226-30. doi: 10.1111/j.1439-0272.2011.01168.x. Epub 2011 Jun 15. <br> <br> Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010 May;12(3):376-80. doi: 10.1038/aja.2010.7. Epub 2010 Mar 29. <br> <br> Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 May 26;10(1):28. doi: 10.1186/1550-2783-10-28. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23705671'>PMID: 23705671</a>; PubMed Central PMCID: PMC3669033. <br> <br> Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23243445'>PMID: 23243445</a>; PubMed Central PMCID: PMC3518798. <br> <br> Abdulghani M, Hussin AH, Sulaiman SA, Chan KL. The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats. Reprod Biol. 2012 Jul;12(2):247-55. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22850474'>PMID: 22850474</a>. <br> <br> Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat Med. 2013;2013:102987. doi: 10.1155/2013/102987. Epub 2013 Aug 25. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24062779'>PMID: 24062779</a>; PubMed Central PMCID: PMC3767077. <br> <br> Saadiah Abdul Razak H, Shuid AN, Naina Mohamed I. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evid Based Complement Alternat Med. 2012;2012:872406. doi: 10.1155/2012/872406. Epub 2012 Aug 9. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22924057'>PMID: 22924057</a>; PubMed Central PMCID: PMC3424595. <br> <br> Shuid AN, El-arabi E, Effendy NM, Razak HS, Muhammad N, Mohamed N, Soelaiman IN. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med. 2012 Sep 12;12:152. doi: 10.1186/1472-6882-12-152. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22967165'>PMID: 22967165</a>; PubMed Central PMCID: PMC3493384. <br> <br> Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79. doi: 10.1016/j.fitote.2010.04.006. Epub 2010 Apr 29. Review. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/20434529'>PMID: 20434529</a>. <br> <br> Farouk AE, Benafri A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J. 2007 Sep;28(9):1422-4. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/17768473'>PMID: 17768473</a>. <br> <br> Nurhanan MY, Azimahtol Hawariah LP, Mohd Ilham A, Mohd Shukri MA. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res. 2005 Nov;19(11):994-6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/16317660'>PMID: 16317660</a>. <br> <br> Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol. 2004 Jun;92(2-3):223-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/15138004'>PMID: 15138004</a>. <br> <br> Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1301-3. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14600377'>PMID: 14600377</a>. <br> <br> Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 2003 Oct;66(10):1324-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14575431'>PMID: 14575431</a>. <br> <br> Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999 Apr;79(4):497-500. 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• increases testosterone levels via HPA axis
• activates 17 α -hydroxylase (CYP17 enzyme)
• inhibits phosphodiesterase
• inhibits aromatase
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=> object(Cake\ORM\Entity) { 'id' => (int) 2670, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f00_web_title' => 'Tongkat Ali (Eurycoma longifolia) - Benefits & Side-Effects', 'f01_header1' => 'Eurycoma longifolia', 'f01_header2' => 'Tongkat Ali', 'f01_header3' => 'Simaroubaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => 'Simaroubaceae', 'f02_body_NHP_summary' => '', 'f02_body1' => 'Reproduction <br> • infertility (male) <br> • <a href='/conditions/erectile-dysfunction' style='text-decoration: none'>erectile dysfunction</a> <br> • hypogonadism <br> <br> Endocrine <br> • stress <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> <br> Musculoskeletal <br> • <a href='/conditions/osteoporosis' style='text-decoration: none'>osteoporosis</a> <br> • athletic performance <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • weight lifting <br> <br> Infection <br> • dysentary <br> • <a href='/conditions/fever' style='text-decoration: none'>fever</a> <br> • lymphadenopathy <br> • parasites (<a href='/conditions/malaria' style='text-decoration: none'>malaria</a>, toxoplasmosi )', 'f02_body2' => '• <a href='/actions/male-tonic' style='text-decoration: none'>Male Tonic</a> <br> • Phytoandrogenic <br> • <a href='/actions/adaptogen' style='text-decoration: none'>Adaptogen</a> <br> • Bitter <br> • Antiosteoporotic <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • Aromatase Inhbitor <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • <a href='/actions/antipyretic' style='text-decoration: none'>Antipyretic</a> <br> • <a href='/actions/anxiolytic' style='text-decoration: none'>Anxiolytic</a> <br> • <a href='/actions/antiinflammatory' style='text-decoration: none'>Antiinflammatory</a> <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • Aromatase Inhibitor', 'f02_body3' => '• Triterpenoids: Quassinoids (E.g. laurycomalactone, Eurycomalactone, Longilactone, Eurylactone, And Eurycomanone) < br > • Alkaloids (E.g. β -Carboline )', 'f02_body4' => '• increases testosterone levels via HPA axis <br> • activates 17 α -hydroxylase (CYP17 enzyme) <br> • inhibits phosphodiesterase <br> • inhibits aromatase', 'f02_body5' => '• Recommended dose has not been established <br> • Typical dose:100-600mg/day (water extract) <br> • Acceptable daily intake (ADI) = 1.2 g/adult/day', 'f02_body6' => '• Generally considered safe <br> • Side-effects: long term consumption may beassociated with sleep apnea, facial flushing, pressure in the testicles, and hyper aggressiveness (no established yet) <br> • LD50 (water extract) = > 6g/kg b.w. <br> <br> Note: in the past several products labelled as <a href='/herbals/tongkat-ali' style='text-decoration: none'>Tongkat Ali</a> have been adulterated with prescription PDE5 inhibitors (i.e. viagara) in both Canada and USA.', 'f02_body7' => '', 'f02_body8' => 'Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014:179529. doi: 10.1155/2014/179529. Epub 2014 Jan 12. PMCID: PMC3914427. <br> <br> Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia. 2012 May;44 Suppl 1:226-30. doi: 10.1111/j.1439-0272.2011.01168.x. Epub 2011 Jun 15. <br> <br> Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010 May;12(3):376-80. doi: 10.1038/aja.2010.7. Epub 2010 Mar 29. <br> <br> Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 May 26;10(1):28. doi: 10.1186/1550-2783-10-28. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23705671'>PMID: 23705671</a>; PubMed Central PMCID: PMC3669033. <br> <br> Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23243445'>PMID: 23243445</a>; PubMed Central PMCID: PMC3518798. <br> <br> Abdulghani M, Hussin AH, Sulaiman SA, Chan KL. The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats. Reprod Biol. 2012 Jul;12(2):247-55. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22850474'>PMID: 22850474</a>. <br> <br> Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat Med. 2013;2013:102987. doi: 10.1155/2013/102987. Epub 2013 Aug 25. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24062779'>PMID: 24062779</a>; PubMed Central PMCID: PMC3767077. <br> <br> Saadiah Abdul Razak H, Shuid AN, Naina Mohamed I. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evid Based Complement Alternat Med. 2012;2012:872406. doi: 10.1155/2012/872406. Epub 2012 Aug 9. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22924057'>PMID: 22924057</a>; PubMed Central PMCID: PMC3424595. <br> <br> Shuid AN, El-arabi E, Effendy NM, Razak HS, Muhammad N, Mohamed N, Soelaiman IN. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med. 2012 Sep 12;12:152. doi: 10.1186/1472-6882-12-152. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22967165'>PMID: 22967165</a>; PubMed Central PMCID: PMC3493384. <br> <br> Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79. doi: 10.1016/j.fitote.2010.04.006. Epub 2010 Apr 29. Review. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/20434529'>PMID: 20434529</a>. <br> <br> Farouk AE, Benafri A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J. 2007 Sep;28(9):1422-4. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/17768473'>PMID: 17768473</a>. <br> <br> Nurhanan MY, Azimahtol Hawariah LP, Mohd Ilham A, Mohd Shukri MA. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res. 2005 Nov;19(11):994-6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/16317660'>PMID: 16317660</a>. <br> <br> Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol. 2004 Jun;92(2-3):223-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/15138004'>PMID: 15138004</a>. <br> <br> Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1301-3. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14600377'>PMID: 14600377</a>. <br> <br> Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 2003 Oct;66(10):1324-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14575431'>PMID: 14575431</a>. <br> <br> Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999 Apr;79(4):497-500. 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reached]], '[repository]' => 'Record' }, (int) 159 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Thyme', 'f00_web_header2' => 'Thymus vulgaris', 'f01_header1' => 'Thymus vulgaris', 'f01_header2' => 'Thyme', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/thyme', 'zkp_ID_t' => 'RECND318', 'zkp_recordID_cn' => '826498', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/thyme', 'f99_hidden' => '/herbals/thyme', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 160 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f01_header1' => 'Eurycoma longifolia', 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'https://www.nhpassist.com/herbals/turmeric', 'f99_hidden' => '/herbals/turmeric', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 162 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Valerian', 'f00_web_header2' => 'Valeriana officinalis', 'f01_header1' => 'Valeriana officinalis', 'f01_header2' => 'Valerian', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/valerian', 'zkp_ID_t' => 'RECND321', 'zkp_recordID_cn' => '826501', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/valerian', 'f99_hidden' => '/herbals/valerian', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum 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object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wild Indigo', 'f00_web_header2' => 'Baptisia tinctoria', 'f01_header1' => 'Baptisia tinctoria', 'f01_header2' => 'Wild Indigo', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wild-indigo', 'zkp_ID_t' => 'RECND327', 'zkp_recordID_cn' => '826507', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wild-indigo', 'f99_hidden' => '/herbals/wild-indigo', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 165 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wild Yam', 'f00_web_header2' => 'Dioscorea villosa', 'f01_header1' => 'Dioscorea villosa', 'f01_header2' => 'Wild Yam', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wild-yam', 'zkp_ID_t' => 'RECND386', 'zkp_recordID_cn' => '826566', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wild-yam', 'f99_hidden' => '/herbals/wild-yam', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 166 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wintergreen', 'f00_web_header2' => 'Gaultheria procumbens', 'f01_header1' => 'Gaultheria procumbens', 'f01_header2' => 'Wintergreen', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wintergreen', 'zkp_ID_t' => 'RECND397', 'zkp_recordID_cn' => '826577', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wintergreen', 'f99_hidden' => '/herbals/wintergreen', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 167 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Witch hazel', 'f00_web_header2' => 'Hamamelis virginiana', 'f01_header1' => 'Hamamelis virginiana', 'f01_header2' => 'Witch hazel', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/witch-hazel', 'zkp_ID_t' => 'RECND323', 'zkp_recordID_cn' => '826503', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/witch-hazel', 'f99_hidden' => '/herbals/witch-hazel', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 168 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wormwood', 'f00_web_header2' => 'Artemisia absinthium', 'f01_header1' => 'Artemisia absinthium', 'f01_header2' => 'Wormwood', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wormwood', 'zkp_ID_t' => 'RECND354', 'zkp_recordID_cn' => '826534', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wormwood', 'f99_hidden' => '/herbals/wormwood', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 169 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Yarrow', 'f00_web_header2' => 'Achillea millefolium', 'f01_header1' => 'Achillea millefolium', 'f01_header2' => 'Yarrow', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/yarrow', 'zkp_ID_t' => 'RECND324', 'zkp_recordID_cn' => '826504', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/yarrow', 'f99_hidden' => '/herbals/yarrow', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 170 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Yellow Dock', 'f00_web_header2' => 'Rumex crispus', 'f01_header1' => 'Rumex crispus', 'f01_header2' => 'Yellow Dock', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/yellow-dock', 'zkp_ID_t' => 'RECND363', 'zkp_recordID_cn' => '826543', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/yellow-dock', 'f99_hidden' => '/herbals/yellow-dock', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' } ] $clipboard = false $keyword_products = [] $url_id = [ (int) 0 => object(Cake\ORM\Entity) { 'label' => 'PubMed?', 'location' => '', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' }, (int) 1 => object(Cake\ORM\Entity) { 'label' => 'Wikipedia', 'location' => 'http://en.wikipedia.org/wiki/Eurycoma_longifolia', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' } ] $pubmed_keyword = 'Eurycoma longifolia' $pubmed_array = [ (int) 0 => '23705671', (int) 1 => '23243445', (int) 2 => '22850474', (int) 3 => '24062779', (int) 4 => '22924057', (int) 5 => '22967165', (int) 6 => '20434529', (int) 7 => '17768473', (int) 8 => '16317660', (int) 9 => '15138004', (int) 10 => '14600377', (int) 11 => '14575431', (int) 12 => '10361892' ] $record = object(Cake\ORM\Entity) { 'id' => (int) 2670, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f00_web_title' => 'Tongkat Ali (Eurycoma longifolia) - Benefits & Side-Effects', 'f01_header1' => 'Eurycoma longifolia', 'f01_header2' => 'Tongkat Ali', 'f01_header3' => 'Simaroubaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => 'Simaroubaceae', 'f02_body_NHP_summary' => '', 'f02_body1' => 'Reproduction <br> • infertility (male) <br> • <a href='/conditions/erectile-dysfunction' style='text-decoration: none'>erectile dysfunction</a> <br> • hypogonadism <br> <br> Endocrine <br> • stress <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> <br> Musculoskeletal <br> • <a href='/conditions/osteoporosis' style='text-decoration: none'>osteoporosis</a> <br> • athletic performance <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • weight lifting <br> <br> Infection <br> • dysentary <br> • <a href='/conditions/fever' style='text-decoration: none'>fever</a> <br> • lymphadenopathy <br> • parasites (<a href='/conditions/malaria' style='text-decoration: none'>malaria</a>, toxoplasmosi )', 'f02_body2' => '• <a href='/actions/male-tonic' style='text-decoration: none'>Male Tonic</a> <br> • Phytoandrogenic <br> • <a href='/actions/adaptogen' style='text-decoration: none'>Adaptogen</a> <br> • Bitter <br> • Antiosteoporotic <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • Aromatase Inhbitor <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • <a href='/actions/antipyretic' style='text-decoration: none'>Antipyretic</a> <br> • <a href='/actions/anxiolytic' style='text-decoration: none'>Anxiolytic</a> <br> • <a href='/actions/antiinflammatory' style='text-decoration: none'>Antiinflammatory</a> <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • Aromatase Inhibitor', 'f02_body3' => '• Triterpenoids: Quassinoids (E.g. laurycomalactone, Eurycomalactone, Longilactone, Eurylactone, And Eurycomanone) < br > • Alkaloids (E.g. β -Carboline )', 'f02_body4' => '• increases testosterone levels via HPA axis <br> • activates 17 α -hydroxylase (CYP17 enzyme) <br> • inhibits phosphodiesterase <br> • inhibits aromatase', 'f02_body5' => '• Recommended dose has not been established <br> • Typical dose:100-600mg/day (water extract) <br> • Acceptable daily intake (ADI) = 1.2 g/adult/day', 'f02_body6' => '• Generally considered safe <br> • Side-effects: long term consumption may beassociated with sleep apnea, facial flushing, pressure in the testicles, and hyper aggressiveness (no established yet) <br> • LD50 (water extract) = > 6g/kg b.w. <br> <br> Note: in the past several products labelled as <a href='/herbals/tongkat-ali' style='text-decoration: none'>Tongkat Ali</a> have been adulterated with prescription PDE5 inhibitors (i.e. viagara) in both Canada and USA.', 'f02_body7' => '', 'f02_body8' => 'Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014:179529. doi: 10.1155/2014/179529. Epub 2014 Jan 12. PMCID: PMC3914427. <br> <br> Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia. 2012 May;44 Suppl 1:226-30. doi: 10.1111/j.1439-0272.2011.01168.x. Epub 2011 Jun 15. <br> <br> Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010 May;12(3):376-80. doi: 10.1038/aja.2010.7. Epub 2010 Mar 29. <br> <br> Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 May 26;10(1):28. doi: 10.1186/1550-2783-10-28. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23705671'>PMID: 23705671</a>; PubMed Central PMCID: PMC3669033. <br> <br> Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23243445'>PMID: 23243445</a>; PubMed Central PMCID: PMC3518798. <br> <br> Abdulghani M, Hussin AH, Sulaiman SA, Chan KL. The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats. Reprod Biol. 2012 Jul;12(2):247-55. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22850474'>PMID: 22850474</a>. <br> <br> Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat Med. 2013;2013:102987. doi: 10.1155/2013/102987. Epub 2013 Aug 25. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24062779'>PMID: 24062779</a>; PubMed Central PMCID: PMC3767077. <br> <br> Saadiah Abdul Razak H, Shuid AN, Naina Mohamed I. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evid Based Complement Alternat Med. 2012;2012:872406. doi: 10.1155/2012/872406. Epub 2012 Aug 9. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22924057'>PMID: 22924057</a>; PubMed Central PMCID: PMC3424595. <br> <br> Shuid AN, El-arabi E, Effendy NM, Razak HS, Muhammad N, Mohamed N, Soelaiman IN. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med. 2012 Sep 12;12:152. doi: 10.1186/1472-6882-12-152. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22967165'>PMID: 22967165</a>; PubMed Central PMCID: PMC3493384. <br> <br> Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79. doi: 10.1016/j.fitote.2010.04.006. Epub 2010 Apr 29. Review. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/20434529'>PMID: 20434529</a>. <br> <br> Farouk AE, Benafri A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J. 2007 Sep;28(9):1422-4. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/17768473'>PMID: 17768473</a>. <br> <br> Nurhanan MY, Azimahtol Hawariah LP, Mohd Ilham A, Mohd Shukri MA. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res. 2005 Nov;19(11):994-6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/16317660'>PMID: 16317660</a>. <br> <br> Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol. 2004 Jun;92(2-3):223-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/15138004'>PMID: 15138004</a>. <br> <br> Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1301-3. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14600377'>PMID: 14600377</a>. <br> <br> Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 2003 Oct;66(10):1324-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14575431'>PMID: 14575431</a>. <br> <br> Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999 Apr;79(4):497-500. 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'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f00_web_title' => 'Tongkat Ali (Eurycoma longifolia) - Benefits & Side-Effects', 'f01_header1' => 'Eurycoma longifolia', 'f01_header2' => 'Tongkat Ali', 'f01_header3' => 'Simaroubaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => 'Simaroubaceae', 'f02_body_NHP_summary' => '', 'f02_body1' => 'Reproduction <br> • infertility (male) <br> • <a href='/conditions/erectile-dysfunction' style='text-decoration: none'>erectile dysfunction</a> <br> • hypogonadism <br> <br> Endocrine <br> • stress <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> <br> Musculoskeletal <br> • <a href='/conditions/osteoporosis' style='text-decoration: none'>osteoporosis</a> <br> • athletic performance <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • weight lifting <br> <br> Infection <br> • dysentary <br> • <a href='/conditions/fever' style='text-decoration: none'>fever</a> <br> • lymphadenopathy <br> • parasites (<a href='/conditions/malaria' style='text-decoration: none'>malaria</a>, toxoplasmosi )', 'f02_body2' => '• <a href='/actions/male-tonic' style='text-decoration: none'>Male Tonic</a> <br> • Phytoandrogenic <br> • <a href='/actions/adaptogen' style='text-decoration: none'>Adaptogen</a> <br> • Bitter <br> • Antiosteoporotic <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • Aromatase Inhbitor <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • <a href='/actions/antipyretic' style='text-decoration: none'>Antipyretic</a> <br> • <a href='/actions/anxiolytic' style='text-decoration: none'>Anxiolytic</a> <br> • <a href='/actions/antiinflammatory' style='text-decoration: none'>Antiinflammatory</a> <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • Aromatase Inhibitor', 'f02_body3' => '• Triterpenoids: Quassinoids (E.g. laurycomalactone, Eurycomalactone, Longilactone, Eurylactone, And Eurycomanone) < br > • Alkaloids (E.g. β -Carboline )', 'f02_body4' => '• increases testosterone levels via HPA axis <br> • activates 17 α -hydroxylase (CYP17 enzyme) <br> • inhibits phosphodiesterase <br> • inhibits aromatase', 'f02_body5' => '• Recommended dose has not been established <br> • Typical dose:100-600mg/day (water extract) <br> • Acceptable daily intake (ADI) = 1.2 g/adult/day', 'f02_body6' => '• Generally considered safe <br> • Side-effects: long term consumption may beassociated with sleep apnea, facial flushing, pressure in the testicles, and hyper aggressiveness (no established yet) <br> • LD50 (water extract) = > 6g/kg b.w. <br> <br> Note: in the past several products labelled as <a href='/herbals/tongkat-ali' style='text-decoration: none'>Tongkat Ali</a> have been adulterated with prescription PDE5 inhibitors (i.e. viagara) in both Canada and USA.', 'f02_body7' => '', 'f02_body8' => 'Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014:179529. doi: 10.1155/2014/179529. Epub 2014 Jan 12. PMCID: PMC3914427. <br> <br> Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia. 2012 May;44 Suppl 1:226-30. doi: 10.1111/j.1439-0272.2011.01168.x. Epub 2011 Jun 15. <br> <br> Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010 May;12(3):376-80. doi: 10.1038/aja.2010.7. Epub 2010 Mar 29. <br> <br> Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 May 26;10(1):28. doi: 10.1186/1550-2783-10-28. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23705671'>PMID: 23705671</a>; PubMed Central PMCID: PMC3669033. <br> <br> Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23243445'>PMID: 23243445</a>; PubMed Central PMCID: PMC3518798. <br> <br> Abdulghani M, Hussin AH, Sulaiman SA, Chan KL. The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats. Reprod Biol. 2012 Jul;12(2):247-55. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22850474'>PMID: 22850474</a>. <br> <br> Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat Med. 2013;2013:102987. doi: 10.1155/2013/102987. Epub 2013 Aug 25. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24062779'>PMID: 24062779</a>; PubMed Central PMCID: PMC3767077. <br> <br> Saadiah Abdul Razak H, Shuid AN, Naina Mohamed I. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evid Based Complement Alternat Med. 2012;2012:872406. doi: 10.1155/2012/872406. Epub 2012 Aug 9. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22924057'>PMID: 22924057</a>; PubMed Central PMCID: PMC3424595. <br> <br> Shuid AN, El-arabi E, Effendy NM, Razak HS, Muhammad N, Mohamed N, Soelaiman IN. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med. 2012 Sep 12;12:152. doi: 10.1186/1472-6882-12-152. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22967165'>PMID: 22967165</a>; PubMed Central PMCID: PMC3493384. <br> <br> Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79. doi: 10.1016/j.fitote.2010.04.006. Epub 2010 Apr 29. Review. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/20434529'>PMID: 20434529</a>. <br> <br> Farouk AE, Benafri A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J. 2007 Sep;28(9):1422-4. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/17768473'>PMID: 17768473</a>. <br> <br> Nurhanan MY, Azimahtol Hawariah LP, Mohd Ilham A, Mohd Shukri MA. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res. 2005 Nov;19(11):994-6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/16317660'>PMID: 16317660</a>. <br> <br> Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol. 2004 Jun;92(2-3):223-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/15138004'>PMID: 15138004</a>. <br> <br> Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1301-3. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14600377'>PMID: 14600377</a>. <br> <br> Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 2003 Oct;66(10):1324-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14575431'>PMID: 14575431</a>. <br> <br> Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999 Apr;79(4):497-500. 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reached]], '[repository]' => 'Record' }, (int) 159 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Thyme', 'f00_web_header2' => 'Thymus vulgaris', 'f01_header1' => 'Thymus vulgaris', 'f01_header2' => 'Thyme', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/thyme', 'zkp_ID_t' => 'RECND318', 'zkp_recordID_cn' => '826498', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/thyme', 'f99_hidden' => '/herbals/thyme', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 160 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f01_header1' => 'Eurycoma longifolia', 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'https://www.nhpassist.com/herbals/turmeric', 'f99_hidden' => '/herbals/turmeric', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 162 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Valerian', 'f00_web_header2' => 'Valeriana officinalis', 'f01_header1' => 'Valeriana officinalis', 'f01_header2' => 'Valerian', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/valerian', 'zkp_ID_t' => 'RECND321', 'zkp_recordID_cn' => '826501', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/valerian', 'f99_hidden' => '/herbals/valerian', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum 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object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wild Indigo', 'f00_web_header2' => 'Baptisia tinctoria', 'f01_header1' => 'Baptisia tinctoria', 'f01_header2' => 'Wild Indigo', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wild-indigo', 'zkp_ID_t' => 'RECND327', 'zkp_recordID_cn' => '826507', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wild-indigo', 'f99_hidden' => '/herbals/wild-indigo', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 165 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wild Yam', 'f00_web_header2' => 'Dioscorea villosa', 'f01_header1' => 'Dioscorea villosa', 'f01_header2' => 'Wild Yam', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wild-yam', 'zkp_ID_t' => 'RECND386', 'zkp_recordID_cn' => '826566', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wild-yam', 'f99_hidden' => '/herbals/wild-yam', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 166 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wintergreen', 'f00_web_header2' => 'Gaultheria procumbens', 'f01_header1' => 'Gaultheria procumbens', 'f01_header2' => 'Wintergreen', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wintergreen', 'zkp_ID_t' => 'RECND397', 'zkp_recordID_cn' => '826577', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wintergreen', 'f99_hidden' => '/herbals/wintergreen', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 167 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Witch hazel', 'f00_web_header2' => 'Hamamelis virginiana', 'f01_header1' => 'Hamamelis virginiana', 'f01_header2' => 'Witch hazel', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/witch-hazel', 'zkp_ID_t' => 'RECND323', 'zkp_recordID_cn' => '826503', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/witch-hazel', 'f99_hidden' => '/herbals/witch-hazel', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 168 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wormwood', 'f00_web_header2' => 'Artemisia absinthium', 'f01_header1' => 'Artemisia absinthium', 'f01_header2' => 'Wormwood', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wormwood', 'zkp_ID_t' => 'RECND354', 'zkp_recordID_cn' => '826534', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wormwood', 'f99_hidden' => '/herbals/wormwood', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 169 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Yarrow', 'f00_web_header2' => 'Achillea millefolium', 'f01_header1' => 'Achillea millefolium', 'f01_header2' => 'Yarrow', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/yarrow', 'zkp_ID_t' => 'RECND324', 'zkp_recordID_cn' => '826504', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/yarrow', 'f99_hidden' => '/herbals/yarrow', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 170 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Yellow Dock', 'f00_web_header2' => 'Rumex crispus', 'f01_header1' => 'Rumex crispus', 'f01_header2' => 'Yellow Dock', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/yellow-dock', 'zkp_ID_t' => 'RECND363', 'zkp_recordID_cn' => '826543', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/yellow-dock', 'f99_hidden' => '/herbals/yellow-dock', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' } ] $clipboard = false $keyword_products = [] $url_id = [ (int) 0 => object(Cake\ORM\Entity) { 'label' => 'PubMed?', 'location' => '', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' }, (int) 1 => object(Cake\ORM\Entity) { 'label' => 'Wikipedia', 'location' => 'http://en.wikipedia.org/wiki/Eurycoma_longifolia', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' } ] $pubmed_keyword = 'Eurycoma longifolia' $pubmed_array = [ (int) 0 => '23705671', (int) 1 => '23243445', (int) 2 => '22850474', (int) 3 => '24062779', (int) 4 => '22924057', (int) 5 => '22967165', (int) 6 => '20434529', (int) 7 => '17768473', (int) 8 => '16317660', (int) 9 => '15138004', (int) 10 => '14600377', (int) 11 => '14575431', (int) 12 => '10361892' ] $record = object(Cake\ORM\Entity) { 'id' => (int) 2670, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f00_web_title' => 'Tongkat Ali (Eurycoma longifolia) - Benefits & Side-Effects', 'f01_header1' => 'Eurycoma longifolia', 'f01_header2' => 'Tongkat Ali', 'f01_header3' => 'Simaroubaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => 'Simaroubaceae', 'f02_body_NHP_summary' => '', 'f02_body1' => 'Reproduction <br> • infertility (male) <br> • <a href='/conditions/erectile-dysfunction' style='text-decoration: none'>erectile dysfunction</a> <br> • hypogonadism <br> <br> Endocrine <br> • stress <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> <br> Musculoskeletal <br> • <a href='/conditions/osteoporosis' style='text-decoration: none'>osteoporosis</a> <br> • athletic performance <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • weight lifting <br> <br> Infection <br> • dysentary <br> • <a href='/conditions/fever' style='text-decoration: none'>fever</a> <br> • lymphadenopathy <br> • parasites (<a href='/conditions/malaria' style='text-decoration: none'>malaria</a>, toxoplasmosi )', 'f02_body2' => '• <a href='/actions/male-tonic' style='text-decoration: none'>Male Tonic</a> <br> • Phytoandrogenic <br> • <a href='/actions/adaptogen' style='text-decoration: none'>Adaptogen</a> <br> • Bitter <br> • Antiosteoporotic <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • Aromatase Inhbitor <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • <a href='/actions/antipyretic' style='text-decoration: none'>Antipyretic</a> <br> • <a href='/actions/anxiolytic' style='text-decoration: none'>Anxiolytic</a> <br> • <a href='/actions/antiinflammatory' style='text-decoration: none'>Antiinflammatory</a> <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • Aromatase Inhibitor', 'f02_body3' => '• Triterpenoids: Quassinoids (E.g. laurycomalactone, Eurycomalactone, Longilactone, Eurylactone, And Eurycomanone) < br > • Alkaloids (E.g. β -Carboline )', 'f02_body4' => '• increases testosterone levels via HPA axis <br> • activates 17 α -hydroxylase (CYP17 enzyme) <br> • inhibits phosphodiesterase <br> • inhibits aromatase', 'f02_body5' => '• Recommended dose has not been established <br> • Typical dose:100-600mg/day (water extract) <br> • Acceptable daily intake (ADI) = 1.2 g/adult/day', 'f02_body6' => '• Generally considered safe <br> • Side-effects: long term consumption may beassociated with sleep apnea, facial flushing, pressure in the testicles, and hyper aggressiveness (no established yet) <br> • LD50 (water extract) = > 6g/kg b.w. <br> <br> Note: in the past several products labelled as <a href='/herbals/tongkat-ali' style='text-decoration: none'>Tongkat Ali</a> have been adulterated with prescription PDE5 inhibitors (i.e. viagara) in both Canada and USA.', 'f02_body7' => '', 'f02_body8' => 'Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014:179529. doi: 10.1155/2014/179529. Epub 2014 Jan 12. PMCID: PMC3914427. <br> <br> Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia. 2012 May;44 Suppl 1:226-30. doi: 10.1111/j.1439-0272.2011.01168.x. Epub 2011 Jun 15. <br> <br> Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010 May;12(3):376-80. doi: 10.1038/aja.2010.7. Epub 2010 Mar 29. <br> <br> Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 May 26;10(1):28. doi: 10.1186/1550-2783-10-28. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23705671'>PMID: 23705671</a>; PubMed Central PMCID: PMC3669033. <br> <br> Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23243445'>PMID: 23243445</a>; PubMed Central PMCID: PMC3518798. <br> <br> Abdulghani M, Hussin AH, Sulaiman SA, Chan KL. The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats. Reprod Biol. 2012 Jul;12(2):247-55. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22850474'>PMID: 22850474</a>. <br> <br> Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat Med. 2013;2013:102987. doi: 10.1155/2013/102987. Epub 2013 Aug 25. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24062779'>PMID: 24062779</a>; PubMed Central PMCID: PMC3767077. <br> <br> Saadiah Abdul Razak H, Shuid AN, Naina Mohamed I. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evid Based Complement Alternat Med. 2012;2012:872406. doi: 10.1155/2012/872406. Epub 2012 Aug 9. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22924057'>PMID: 22924057</a>; PubMed Central PMCID: PMC3424595. <br> <br> Shuid AN, El-arabi E, Effendy NM, Razak HS, Muhammad N, Mohamed N, Soelaiman IN. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med. 2012 Sep 12;12:152. doi: 10.1186/1472-6882-12-152. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22967165'>PMID: 22967165</a>; PubMed Central PMCID: PMC3493384. <br> <br> Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79. doi: 10.1016/j.fitote.2010.04.006. Epub 2010 Apr 29. Review. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/20434529'>PMID: 20434529</a>. <br> <br> Farouk AE, Benafri A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J. 2007 Sep;28(9):1422-4. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/17768473'>PMID: 17768473</a>. <br> <br> Nurhanan MY, Azimahtol Hawariah LP, Mohd Ilham A, Mohd Shukri MA. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res. 2005 Nov;19(11):994-6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/16317660'>PMID: 16317660</a>. <br> <br> Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol. 2004 Jun;92(2-3):223-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/15138004'>PMID: 15138004</a>. <br> <br> Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1301-3. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14600377'>PMID: 14600377</a>. <br> <br> Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 2003 Oct;66(10):1324-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14575431'>PMID: 14575431</a>. <br> <br> Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999 Apr;79(4):497-500. 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• Recommended dose has not been established
• Typical dose:100-600mg/day (water extract)
• Acceptable daily intake (ADI) = 1.2 g/adult/day
• Generally considered safe
• Side-effects: long term consumption may beassociated with sleep apnea, facial flushing, pressure in the testicles, and hyper aggressiveness (no established yet)
• LD50 (water extract) = > 6g/kg b.w.
Note: in the past several products labelled as Tongkat Ali have been adulterated with prescription PDE5 inhibitors (i.e. viagara) in both Canada and USA.
Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014:179529. doi: 10.1155/2014/179529. Epub 2014 Jan 12. PMCID: PMC3914427.
Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia. 2012 May;44 Suppl 1:226-30. doi: 10.1111/j.1439-0272.2011.01168.x. Epub 2011 Jun 15.
Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010 May;12(3):376-80. doi: 10.1038/aja.2010.7. Epub 2010 Mar 29.
Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 May 26;10(1):28. doi: 10.1186/1550-2783-10-28. PubMed PMID: 23705671; PubMed Central PMCID: PMC3669033.
Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1. PubMed PMID: 23243445; PubMed Central PMCID: PMC3518798.
Abdulghani M, Hussin AH, Sulaiman SA, Chan KL. The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats. Reprod Biol. 2012 Jul;12(2):247-55. PubMed PMID: 22850474.
Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat Med. 2013;2013:102987. doi: 10.1155/2013/102987. Epub 2013 Aug 25. PubMed PMID: 24062779; PubMed Central PMCID: PMC3767077.
Saadiah Abdul Razak H, Shuid AN, Naina Mohamed I. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evid Based Complement Alternat Med. 2012;2012:872406. doi: 10.1155/2012/872406. Epub 2012 Aug 9. PubMed PMID: 22924057; PubMed Central PMCID: PMC3424595.
Shuid AN, El-arabi E, Effendy NM, Razak HS, Muhammad N, Mohamed N, Soelaiman IN. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med. 2012 Sep 12;12:152. doi: 10.1186/1472-6882-12-152. PubMed PMID: 22967165; PubMed Central PMCID: PMC3493384.
Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79. doi: 10.1016/j.fitote.2010.04.006. Epub 2010 Apr 29. Review. PubMed PMID: 20434529.
Farouk AE, Benafri A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J. 2007 Sep;28(9):1422-4. PubMed PMID: 17768473.
Nurhanan MY, Azimahtol Hawariah LP, Mohd Ilham A, Mohd Shukri MA. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res. 2005 Nov;19(11):994-6. PubMed PMID: 16317660.
Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol. 2004 Jun;92(2-3):223-7. PubMed PMID: 15138004.
Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1301-3. PubMed PMID: 14600377.
Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 2003 Oct;66(10):1324-7. PubMed PMID: 14575431.
Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999 Apr;79(4):497-500. PubMed PMID: 10361892.
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2670, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f00_web_title' => 'Tongkat Ali (Eurycoma longifolia) - Benefits & Side-Effects', 'f01_header1' => 'Eurycoma longifolia', 'f01_header2' => 'Tongkat Ali', 'f01_header3' => 'Simaroubaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => 'Simaroubaceae', 'f02_body_NHP_summary' => '', 'f02_body1' => 'Reproduction <br> • infertility (male) <br> • <a href='/conditions/erectile-dysfunction' style='text-decoration: none'>erectile dysfunction</a> <br> • hypogonadism <br> <br> Endocrine <br> • stress <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> <br> Musculoskeletal <br> • <a href='/conditions/osteoporosis' style='text-decoration: none'>osteoporosis</a> <br> • athletic performance <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • weight lifting <br> <br> Infection <br> • dysentary <br> • <a href='/conditions/fever' style='text-decoration: none'>fever</a> <br> • lymphadenopathy <br> • parasites (<a href='/conditions/malaria' style='text-decoration: none'>malaria</a>, toxoplasmosi )', 'f02_body2' => '• <a href='/actions/male-tonic' style='text-decoration: none'>Male Tonic</a> <br> • Phytoandrogenic <br> • <a href='/actions/adaptogen' style='text-decoration: none'>Adaptogen</a> <br> • Bitter <br> • Antiosteoporotic <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • Aromatase Inhbitor <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • <a href='/actions/antipyretic' style='text-decoration: none'>Antipyretic</a> <br> • <a href='/actions/anxiolytic' style='text-decoration: none'>Anxiolytic</a> <br> • <a href='/actions/antiinflammatory' style='text-decoration: none'>Antiinflammatory</a> <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • Aromatase Inhibitor', 'f02_body3' => '• Triterpenoids: Quassinoids (E.g. laurycomalactone, Eurycomalactone, Longilactone, Eurylactone, And Eurycomanone) < br > • Alkaloids (E.g. β -Carboline )', 'f02_body4' => '• increases testosterone levels via HPA axis <br> • activates 17 α -hydroxylase (CYP17 enzyme) <br> • inhibits phosphodiesterase <br> • inhibits aromatase', 'f02_body5' => '• Recommended dose has not been established <br> • Typical dose:100-600mg/day (water extract) <br> • Acceptable daily intake (ADI) = 1.2 g/adult/day', 'f02_body6' => '• Generally considered safe <br> • Side-effects: long term consumption may beassociated with sleep apnea, facial flushing, pressure in the testicles, and hyper aggressiveness (no established yet) <br> • LD50 (water extract) = > 6g/kg b.w. <br> <br> Note: in the past several products labelled as <a href='/herbals/tongkat-ali' style='text-decoration: none'>Tongkat Ali</a> have been adulterated with prescription PDE5 inhibitors (i.e. viagara) in both Canada and USA.', 'f02_body7' => '', 'f02_body8' => 'Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014:179529. doi: 10.1155/2014/179529. Epub 2014 Jan 12. PMCID: PMC3914427. <br> <br> Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia. 2012 May;44 Suppl 1:226-30. doi: 10.1111/j.1439-0272.2011.01168.x. Epub 2011 Jun 15. <br> <br> Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010 May;12(3):376-80. doi: 10.1038/aja.2010.7. Epub 2010 Mar 29. <br> <br> Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 May 26;10(1):28. doi: 10.1186/1550-2783-10-28. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23705671'>PMID: 23705671</a>; PubMed Central PMCID: PMC3669033. <br> <br> Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23243445'>PMID: 23243445</a>; PubMed Central PMCID: PMC3518798. <br> <br> Abdulghani M, Hussin AH, Sulaiman SA, Chan KL. The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats. Reprod Biol. 2012 Jul;12(2):247-55. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22850474'>PMID: 22850474</a>. <br> <br> Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat Med. 2013;2013:102987. doi: 10.1155/2013/102987. Epub 2013 Aug 25. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24062779'>PMID: 24062779</a>; PubMed Central PMCID: PMC3767077. <br> <br> Saadiah Abdul Razak H, Shuid AN, Naina Mohamed I. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evid Based Complement Alternat Med. 2012;2012:872406. doi: 10.1155/2012/872406. Epub 2012 Aug 9. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22924057'>PMID: 22924057</a>; PubMed Central PMCID: PMC3424595. <br> <br> Shuid AN, El-arabi E, Effendy NM, Razak HS, Muhammad N, Mohamed N, Soelaiman IN. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med. 2012 Sep 12;12:152. doi: 10.1186/1472-6882-12-152. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22967165'>PMID: 22967165</a>; PubMed Central PMCID: PMC3493384. <br> <br> Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79. doi: 10.1016/j.fitote.2010.04.006. Epub 2010 Apr 29. Review. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/20434529'>PMID: 20434529</a>. <br> <br> Farouk AE, Benafri A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J. 2007 Sep;28(9):1422-4. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/17768473'>PMID: 17768473</a>. <br> <br> Nurhanan MY, Azimahtol Hawariah LP, Mohd Ilham A, Mohd Shukri MA. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res. 2005 Nov;19(11):994-6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/16317660'>PMID: 16317660</a>. <br> <br> Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol. 2004 Jun;92(2-3):223-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/15138004'>PMID: 15138004</a>. <br> <br> Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1301-3. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14600377'>PMID: 14600377</a>. <br> <br> Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 2003 Oct;66(10):1324-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14575431'>PMID: 14575431</a>. <br> <br> Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999 Apr;79(4):497-500. 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=> 'Record' }, (int) 29 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Butterbur', 'f00_web_header2' => 'Petasites hybridus', 'f01_header1' => 'Petasites hybridus', 'f01_header2' => 'Butterbur', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/butterbur', 'zkp_ID_t' => 'RECND252', 'zkp_recordID_cn' => '826432', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/butterbur', 'f99_hidden' => '/herbals/butterbur', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 30 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Calendula or Pot Marigold', 'f00_web_header2' => 'Calendula officinalis', 'f01_header1' => 'Calendula 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reached]], '[repository]' => 'Record' }, (int) 39 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Chamomile (German )', 'f00_web_header2' => 'Matricaria recutita', 'f01_header1' => 'Matricaria recutita', 'f01_header2' => 'Chamomile (German )', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/chamomile-german', 'zkp_ID_t' => 'RECND275', 'zkp_recordID_cn' => '826455', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/chamomile-german', 'f99_hidden' => '/herbals/chamomile-german', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 40 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Chaste Tree', 'f00_web_header2' => 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reached]], '[repository]' => 'Record' }, (int) 159 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Thyme', 'f00_web_header2' => 'Thymus vulgaris', 'f01_header1' => 'Thymus vulgaris', 'f01_header2' => 'Thyme', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/thyme', 'zkp_ID_t' => 'RECND318', 'zkp_recordID_cn' => '826498', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/thyme', 'f99_hidden' => '/herbals/thyme', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 160 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f01_header1' => 'Eurycoma longifolia', 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'https://www.nhpassist.com/herbals/turmeric', 'f99_hidden' => '/herbals/turmeric', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 162 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Valerian', 'f00_web_header2' => 'Valeriana officinalis', 'f01_header1' => 'Valeriana officinalis', 'f01_header2' => 'Valerian', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/valerian', 'zkp_ID_t' => 'RECND321', 'zkp_recordID_cn' => '826501', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/valerian', 'f99_hidden' => '/herbals/valerian', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum 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object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wild Indigo', 'f00_web_header2' => 'Baptisia tinctoria', 'f01_header1' => 'Baptisia tinctoria', 'f01_header2' => 'Wild Indigo', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wild-indigo', 'zkp_ID_t' => 'RECND327', 'zkp_recordID_cn' => '826507', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wild-indigo', 'f99_hidden' => '/herbals/wild-indigo', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 165 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wild Yam', 'f00_web_header2' => 'Dioscorea villosa', 'f01_header1' => 'Dioscorea villosa', 'f01_header2' => 'Wild Yam', 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'f99_hidden' => '/herbals/wintergreen', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 167 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Witch hazel', 'f00_web_header2' => 'Hamamelis virginiana', 'f01_header1' => 'Hamamelis virginiana', 'f01_header2' => 'Witch hazel', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/witch-hazel', 'zkp_ID_t' => 'RECND323', 'zkp_recordID_cn' => '826503', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/witch-hazel', 'f99_hidden' => '/herbals/witch-hazel', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 168 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Wormwood', 'f00_web_header2' => 'Artemisia absinthium', 'f01_header1' => 'Artemisia absinthium', 'f01_header2' => 'Wormwood', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wormwood', 'zkp_ID_t' => 'RECND354', 'zkp_recordID_cn' => '826534', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wormwood', 'f99_hidden' => '/herbals/wormwood', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 169 => object(Cake\ORM\Entity) { 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'https://www.nhpassist.com/herbals/herbals/yellow-dock', 'zkp_ID_t' => 'RECND363', 'zkp_recordID_cn' => '826543', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/yellow-dock', 'f99_hidden' => '/herbals/yellow-dock', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' } ] $clipboard = false $keyword_products = [] $url_id = [ (int) 0 => object(Cake\ORM\Entity) { 'label' => 'PubMed?', 'location' => '', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' }, (int) 1 => object(Cake\ORM\Entity) { 'label' => 'Wikipedia', 'location' => 'http://en.wikipedia.org/wiki/Eurycoma_longifolia', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' } ] $pubmed_keyword = 'Eurycoma longifolia' $pubmed_array = [ (int) 0 => '23705671', (int) 1 => '23243445', (int) 2 => '22850474', (int) 3 => '24062779', (int) 4 => '22924057', (int) 5 => '22967165', (int) 6 => '20434529', (int) 7 => '17768473', (int) 8 => '16317660', (int) 9 => '15138004', (int) 10 => '14600377', (int) 11 => '14575431', (int) 12 => '10361892' ] $record = object(Cake\ORM\Entity) { 'id' => (int) 2670, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Tongkat Ali', 'f00_web_header2' => 'Eurycoma longifolia', 'f00_web_title' => 'Tongkat Ali (Eurycoma longifolia) - Benefits & Side-Effects', 'f01_header1' => 'Eurycoma longifolia', 'f01_header2' => 'Tongkat Ali', 'f01_header3' => 'Simaroubaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => 'Simaroubaceae', 'f02_body_NHP_summary' => '', 'f02_body1' => 'Reproduction <br> • infertility (male) <br> • <a href='/conditions/erectile-dysfunction' style='text-decoration: none'>erectile dysfunction</a> <br> • hypogonadism <br> <br> Endocrine <br> • stress <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> <br> Musculoskeletal <br> • <a href='/conditions/osteoporosis' style='text-decoration: none'>osteoporosis</a> <br> • athletic performance <br> • <a href='/conditions/weight-loss' style='text-decoration: none'>weight loss</a> <br> • weight lifting <br> <br> Infection <br> • dysentary <br> • <a href='/conditions/fever' style='text-decoration: none'>fever</a> <br> • lymphadenopathy <br> • parasites (<a href='/conditions/malaria' style='text-decoration: none'>malaria</a>, toxoplasmosi )', 'f02_body2' => '• <a href='/actions/male-tonic' style='text-decoration: none'>Male Tonic</a> <br> • Phytoandrogenic <br> • <a href='/actions/adaptogen' style='text-decoration: none'>Adaptogen</a> <br> • Bitter <br> • Antiosteoporotic <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • Aromatase Inhbitor <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • <a href='/actions/antipyretic' style='text-decoration: none'>Antipyretic</a> <br> • <a href='/actions/anxiolytic' style='text-decoration: none'>Anxiolytic</a> <br> • <a href='/actions/antiinflammatory' style='text-decoration: none'>Antiinflammatory</a> <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> • Aromatase Inhibitor', 'f02_body3' => '• Triterpenoids: Quassinoids (E.g. laurycomalactone, Eurycomalactone, Longilactone, Eurylactone, And Eurycomanone) < br > • Alkaloids (E.g. β -Carboline )', 'f02_body4' => '• increases testosterone levels via HPA axis <br> • activates 17 α -hydroxylase (CYP17 enzyme) <br> • inhibits phosphodiesterase <br> • inhibits aromatase', 'f02_body5' => '• Recommended dose has not been established <br> • Typical dose:100-600mg/day (water extract) <br> • Acceptable daily intake (ADI) = 1.2 g/adult/day', 'f02_body6' => '• Generally considered safe <br> • Side-effects: long term consumption may beassociated with sleep apnea, facial flushing, pressure in the testicles, and hyper aggressiveness (no established yet) <br> • LD50 (water extract) = > 6g/kg b.w. <br> <br> Note: in the past several products labelled as <a href='/herbals/tongkat-ali' style='text-decoration: none'>Tongkat Ali</a> have been adulterated with prescription PDE5 inhibitors (i.e. viagara) in both Canada and USA.', 'f02_body7' => '', 'f02_body8' => 'Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014:179529. doi: 10.1155/2014/179529. Epub 2014 Jan 12. PMCID: PMC3914427. <br> <br> Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia. 2012 May;44 Suppl 1:226-30. doi: 10.1111/j.1439-0272.2011.01168.x. Epub 2011 Jun 15. <br> <br> Tambi MI, Imran MK. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010 May;12(3):376-80. doi: 10.1038/aja.2010.7. Epub 2010 Mar 29. <br> <br> Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. J Int Soc Sports Nutr. 2013 May 26;10(1):28. doi: 10.1186/1550-2783-10-28. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23705671'>PMID: 23705671</a>; PubMed Central PMCID: PMC3669033. <br> <br> Ismail SB, Wan Mohammad WM, George A, Nik Hussain NH, Musthapa Kamal ZM, Liske E. Randomized Clinical Trial on the Use of PHYSTA Freeze-Dried Water Extract of Eurycoma longifolia for the Improvement of Quality of Life and Sexual Well-Being in Men. Evid Based Complement Alternat Med. 2012;2012:429268. doi: 10.1155/2012/429268. Epub 2012 Nov 1. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/23243445'>PMID: 23243445</a>; PubMed Central PMCID: PMC3518798. <br> <br> Abdulghani M, Hussin AH, Sulaiman SA, Chan KL. The ameliorative effects of Eurycoma longifolia Jack on testosterone-induced reproductive disorders in female rats. Reprod Biol. 2012 Jul;12(2):247-55. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22850474'>PMID: 22850474</a>. <br> <br> Li CH, Liao JW, Liao PL, Huang WK, Tse LS, Lin CH, Kang JJ, Cheng YW. Evaluation of Acute 13-Week Subchronic Toxicity and Genotoxicity of the Powdered Root of Tongkat Ali (Eurycoma longifolia Jack). Evid Based Complement Alternat Med. 2013;2013:102987. doi: 10.1155/2013/102987. Epub 2013 Aug 25. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24062779'>PMID: 24062779</a>; PubMed Central PMCID: PMC3767077. <br> <br> Saadiah Abdul Razak H, Shuid AN, Naina Mohamed I. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evid Based Complement Alternat Med. 2012;2012:872406. doi: 10.1155/2012/872406. Epub 2012 Aug 9. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22924057'>PMID: 22924057</a>; PubMed Central PMCID: PMC3424595. <br> <br> Shuid AN, El-arabi E, Effendy NM, Razak HS, Muhammad N, Mohamed N, Soelaiman IN. Eurycoma longifolia upregulates osteoprotegerin gene expression in androgen- deficient osteoporosis rat model. BMC Complement Altern Med. 2012 Sep 12;12:152. doi: 10.1186/1472-6882-12-152. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/22967165'>PMID: 22967165</a>; PubMed Central PMCID: PMC3493384. <br> <br> Bhat R, Karim AA. Tongkat Ali (Eurycoma longifolia Jack): a review on its ethnobotany and pharmacological importance. Fitoterapia. 2010 Oct;81(7):669-79. doi: 10.1016/j.fitote.2010.04.006. Epub 2010 Apr 29. Review. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/20434529'>PMID: 20434529</a>. <br> <br> Farouk AE, Benafri A. Antibacterial activity of Eurycoma longifolia Jack. A Malaysian medicinal plant. Saudi Med J. 2007 Sep;28(9):1422-4. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/17768473'>PMID: 17768473</a>. <br> <br> Nurhanan MY, Azimahtol Hawariah LP, Mohd Ilham A, Mohd Shukri MA. Cytotoxic effects of the root extracts of Eurycoma longifolia Jack. Phytother Res. 2005 Nov;19(11):994-6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/16317660'>PMID: 16317660</a>. <br> <br> Chan KL, Choo CY, Abdullah NR, Ismail Z. Antiplasmodial studies of Eurycoma longifolia Jack using the lactate dehydrogenase assay of Plasmodium falciparum. J Ethnopharmacol. 2004 Jun;92(2-3):223-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/15138004'>PMID: 15138004</a>. <br> <br> Bedir E, Abou-Gazar H, Ngwendson JN, Khan IA. Eurycomaoside: a new quassinoid-type glycoside from the roots of Eurycoma longifolia. Chem Pharm Bull (Tokyo). 2003 Nov;51(11):1301-3. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14600377'>PMID: 14600377</a>. <br> <br> Kuo PC, Shi LS, Damu AG, Su CR, Huang CH, Ke CH, Wu JB, Lin AJ, Bastow KF, Lee KH, Wu TS. Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. J Nat Prod. 2003 Oct;66(10):1324-7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/14575431'>PMID: 14575431</a>. <br> <br> Ang HH, Cheang HS. Studies on the anxiolytic activity of Eurycoma longifolia Jack roots in mice. Jpn J Pharmacol. 1999 Apr;79(4):497-500. 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45 => 'vitamin_B7', (int) 46 => 'Astragalus_membranaceus', (int) 47 => 'stye', (int) 48 => 'Tongkat_Ali', (int) 49 => 'usnea' ] $type = 'Botanicals' $brand_product = false $title = 'Eurycoma longifolia - Tongkat Ali' $description = 'Tongkat Ali - Eurycoma longifolia used for diabetes, stress, weight loss, fever, inflammation, erectile dysfunction, atheletic, arthritis, osteoporosis, parasit' $category = 'Botanicals' $breadcumbs = [ (int) 0 => '', (int) 1 => 'herbals', (int) 2 => 'tongkat-ali' ] $breadcumbs_links = [ (int) 0 => '', (int) 1 => 'herbals', (int) 2 => 'tongkat-ali' ] $_pubmed_id = '10361892' $sender_email = '' $subject = 'Tongkat Ali' $image = 'tongkat-ali-eurycoma-longifolia' $image_Url = 'https://www.nhpassist.com//images/Pictures/tongkat-ali-eurycoma-longifolia.jpg'include - APP/Template/Products/index.ctp, line 938 Cake\View\View::_evaluate() - CORE/src/View/View.php, line 1419 Cake\View\View::_render() - CORE/src/View/View.php, line 1380 Cake\View\View::render() - 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Tongkat Ali
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