| Scientific: | Silybum marianum |
|---|---|
| Other: | Milk Thistle |
| Family: | Asteraceae |
| Synonym: | Carduus marianus |
Milk thistle goes by many names including St. Mary's thistle, blessed thistle, and cardus marianus. To add to the confusion, it has two acceptable latin binomials (Silybum marianum and Carduus marianus). Most herbalists call it milk thistle (Silybum marianum) because of the milky white veins that run through its green leaves.
Although coincidentally milk thistle has documented galactagogue effects, its primary indication is for liver ailments. Most of the medicinal benefits focus on silymarin, which is a mixture of three flavonolignans (silibinin, silychristin, and silydianin). These polyphenols have significant antioxidant and hepatoprotective effects that appear to support various detox pathways in the liver and stimulate liver regeneration to protects the liver from various toxins including alcohol and drugs. Silymarin stabilizes cell membranes, stimulates protein synthesis and accelerates liver regeneration to lower liver enzymes and reduce the progression to cirrhosis. Interestingly, silymarin may help in treating amanita mushroom poisoning, which currently there's no promising antidote. However, clinical trials on the benefits of milk thistle on viral hepatitis remain inconclusive at best.
Silymarin could be an insulin sensitizer, and clinical trials show it improves glycemic control and lipid levels in diabetic patients. Also, people with non-alcohol fatty liver disease (NAFLD), which obesity and diabetes are risk factors, benefit from taking milk thistle extracts. Because of its antioxidant effects, milk thistle may also aid help to prevent atherosclerosis.
One particularly exciting area of research is the inhibitory effect that silymarin has on multi-drug resistant (MDR) pumps that are responsible for certain types of drug resistance. Further research is needed to determine if co-administration of silymarin with some antibiotics and anticancer drugs could increase their efficacy.
Hepatobiliary
• various liver complaints
• jaundice
• viral hepatitis (HBV, HCV)
• drug-induced hepatitis
• non-alcoholic fatty liver disease (NAFLD)
Gastrointestinal
• poor appetite
- poor digestion
- dyspepsia
- hypochlorhydria
• peptic ulcers
• ulcerative colitis
Cardiovascular
• hypercholesterolemia
• atherosclerosis
Metabolic
• type II diabetes
• diabetic nephropathy
• gout
Female reproductive
• agalactia (poor lactation)
Cancer
• chemotherapy - decreases hepatotoxicity and nephrotoxicity
Dermatologic
• acne rosacea
Other
• mercury poisoning
• obsessive-compulsive disorder (OCD )
• Hepatoprotective
• Nephroprotective
• Cardioprotective
• Hepatic
• Bitter (mild)
• Galactagogue
• Antiulcerogenic
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Side-Effects', 'f01_header1' => 'Silybum marianum', 'f01_header2' => 'Milk Thistle', 'f01_header3' => 'Asteraceae', 'f01_header4' => 'Carduus marianus', 'f01_header5' => 'Asteraceae', 'f01_header6' => 'Asteraceae', 'f02_body_NHP_summary' => '<a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>Milk thistle</a> goes by many names including St. Mary's thistle, blessed thistle, and cardus marianus. To add to the confusion, it has two acceptable latin binomials (Silybum marianum and Carduus marianus). Most herbalists call it <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> (Silybum marianum) because of the milky white veins that run through its green leaves. <br> <br> Although coincidentally <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> has documented <a href="https://www.nhpassist.com//actions/galactagogue" style='text-decoration: none'>galactagogue</a> effects, its primary indication is for liver ailments. Most of the medicinal benefits focus on silymarin, which is a mixture of three flavonolignans (silibinin, silychristin, and silydianin). These polyphenols have significant <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> and <a href="https://www.nhpassist.com//actions/hepatoprotective" style='text-decoration: none'>hepatoprotective</a> effects that appear to support various detox pathways in the liver and stimulate liver regeneration to protects the liver from various toxins including alcohol and drugs. Silymarin stabilizes cell membranes, stimulates protein synthesis and accelerates liver regeneration to lower liver enzymes and reduce the progression to cirrhosis. Interestingly, silymarin may help in treating amanita mushroom poisoning, which currently there's no promising antidote. However, clinical trials on the benefits of <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> on viral <a href="https://www.nhpassist.com//conditions/hepatitis" style='text-decoration: none'>hepatitis</a> remain inconclusive at best. <br> <br> Silymarin could be an insulin sensitizer, and clinical trials show it improves glycemic control and lipid levels in diabetic patients. Also, people with non-alcohol <a href="https://www.nhpassist.com//conditions/fatty-liver" style='text-decoration: none'>fatty liver</a> disease (NAFLD), which <a href="https://www.nhpassist.com//conditions/weight-loss" style='text-decoration: none'>obesity</a> and <a href="https://www.nhpassist.com//conditions/diabetes-mellitus" style='text-decoration: none'>diabetes</a> are risk factors, benefit from taking <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> extracts. Because of its <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> effects, <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> may also aid help to prevent <a href="https://www.nhpassist.com//conditions/cholesterol" style='text-decoration: none'>atherosclerosis</a>. <br> <br> One particularly exciting area of research is the inhibitory effect that silymarin has on multi-drug resistant (MDR) pumps that are responsible for certain types of drug resistance. Further research is needed to determine if co-administration of silymarin with some antibiotics and <a href="https://www.nhpassist.com//actions/anticancer" style='text-decoration: none'>anticancer</a> drugs could increase their efficacy.', 'f02_body1' => 'Hepatobiliary <br> • various liver complaints <br> • jaundice <br> • viral <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> (<a href='/conditions/hepatitis' style='text-decoration: none'>HBV</a>, <a href='/conditions/hepatitis' style='text-decoration: none'>HCV</a>) <br> • drug-induced <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> <br> • non-alcoholic <a href='/conditions/fatty-liver' style='text-decoration: none'>fatty liver</a> disease (NAFLD) <br> <br> Gastrointestinal <br> • poor appetite <br> - poor digestion <br> - <a href='/conditions/indigestion' style='text-decoration: none'>dyspepsia</a> <br> - <a href='/conditions/hypochlorhydria' style='text-decoration: none'>hypochlorhydria</a> <br> • <a href='/conditions/stomach-ulcer' style='text-decoration: none'>peptic ulcers</a> <br> • ulcerative colitis <br> <br> Cardiovascular <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>hypercholesterolemia</a> <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>atherosclerosis</a> <br> <br> Metabolic <br> • type II <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> • diabetic nephropathy <br> • <a href='/conditions/gout' style='text-decoration: none'>gout</a> <br> <br> Female reproductive <br> • <a href='/conditions/lactation' style='text-decoration: none'>agalactia</a> (poor <a href='/conditions/lactation' style='text-decoration: none'>lactation</a>) <br> <br> Cancer <br> • chemotherapy - decreases hepatotoxicity and nephrotoxicity <br> <br> Dermatologic <br> • <a href='/conditions/acne-vulgaris' style='text-decoration: none'>acne</a> <a href='/conditions/rosacea' style='text-decoration: none'>rosacea</a> <br> <br> Other <br> • <a href='/conditions/mercury-poisoning' style='text-decoration: none'>mercury poisoning</a> <br> • obsessive-compulsive disorder (<a href='/conditions/obsessive-compulsive-disorder' style='text-decoration: none'>OCD</a> )', 'f02_body2' => '• <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatic' style='text-decoration: none'>Hepatic</a> <br> • Bitter (mild) <br> • <a href='/actions/galactagogue' style='text-decoration: none'>Galactagogue</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Antiulcerogenic</a>', 'f02_body3' => '• Flavolignans (E.g. Silymarin) <br> • Phenoilc Acids <br> • Sterols (E.g. Beta-Sitosterol )', 'f02_body4' => '', 'f02_body5' => '• Tincture (1:5 in 60% EtOH): 2-5 ml tid <br> • Liquid extract (1:1 in 25% EtOH): 2-6 ml tid <br> • Decoction (seeds): 1 tsp tid <br> • Standardized extract (70% silymarin): 600 mg/d <br> <br> Note: Leaf preparations are devoid of flavolignans, which are found in the seeds.', 'f02_body6' => 'Generally considered safe when used as indicated. <br> <br> Contra-Indications: <br> • gastritis & <a href='/conditions/stomach-ulcer' style='text-decoration: none'>stomach ulcers</a> <br> • obstructed gallbladder <br> <br> Caution: <br> • Asteraceae allergy: contains sesquiterpene lactones <br> <br> <a href='/conditions/pregnancy' style='text-decoration: none'>Pregnancy</a> & Lactaction: <br> • Considered safe', 'f02_body7' => 'Milk thistle may affect the drug metabolism by: <br> • CYP2C9 • may reduce clearance of drugs metabolized by this p450 <br> • Glucuronidation <br> <br> <br> Milk thistle is known to interact with the following drugs: <br> • deferiprone <br> • indinavir <br> • raloxifene <br> • simeprevir', 'f02_body8' => 'Barnes J, Anderson LA, Phillipson JD. Herbal Medicines, 3rd ed. London: Pharmaceutical Press, 2007. <br> <br> Bone K. Principles and Practice of Phytotherapy. Edinburgh: Churchill Livingstone, 2000. <br> <br> Bone K. A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient. St Louis, MO: Churchill Livingstone, 2003. <br> <br> Brinker F. The Toxicology of Botanical Medicines, 3rd ed. Sandy, Oregon: Eclectic Medical Publications, 2000. <br> <br> Felter HW, Lloyd JU. King's American Dispensatory. 1898. http://www.ibiblio.org/herbmed/eclectic/kings/main.html. Accessed: August 19, 2006. <br> <br> Hoffman D. Medical Herbalism. Rochester, Vermont: Healing Arts Press, 2003. <br> <br> Weiss RF. Herbal Medicine. Beaconsfield, England: Beaconsfield Publishers Ltd, 1988. <br> <br> Williamson EM, ed. Major Herbs of Ayurveda. 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}, (int) 18 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Black Cohosh', 'f00_web_header2' => 'Cimicifuga racemosa', 'f01_header1' => 'Cimicifuga racemosa', 'f01_header2' => 'Black Cohosh', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/black-cohosh', 'zkp_ID_t' => 'RECND381', 'zkp_recordID_cn' => '826561', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/black-cohosh', 'f99_hidden' => '/herbals/black-cohosh', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 19 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Black Walnut', 'f00_web_header2' => 'Juglans nigra', 'f01_header1' => 'Juglans nigra', 'f01_header2' => 'Black Walnut', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/black-walnut', 'zkp_ID_t' => 'RECND379', 'zkp_recordID_cn' => '826559', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/black-walnut', 'f99_hidden' => '/herbals/black-walnut', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 20 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Bloodroot', 'f00_web_header2' => 'Sanguinaria canadensis', 'f01_header1' => 'Sanguinaria canadensis', 'f01_header2' => 'Bloodroot', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/bloodroot', 'zkp_ID_t' => 'RECND248', 'zkp_recordID_cn' => '826428', 'f03_imageURL_t' => 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(int) 23 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Bogbean', 'f00_web_header2' => 'Buckbean', 'f01_header1' => 'Menyanthes trifoliata', 'f01_header2' => 'Bogbean', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/bogbean', 'zkp_ID_t' => 'REC109add9e526752', 'zkp_recordID_cn' => '830894', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/bogbean', 'f99_hidden' => '/herbals/bogbean', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 24 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Boldo', 'f00_web_header2' => 'Peumus boldus', 'f01_header1' => 'Peumus boldus', 'f01_header2' => 'Boldo', 'f03_web_image_URL' => 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reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 26 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Buchu', 'f00_web_header2' => 'Agathosma betulina', 'f01_header1' => 'Agathosma betulina', 'f01_header2' => 'Buchu & Barosma', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/buchu-&-barosma', 'zkp_ID_t' => 'RECND251', 'zkp_recordID_cn' => '826431', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/buchu-&-barosma', 'f99_hidden' => '/herbals/buchu-barosma', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 27 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Burdock', 'f00_web_header2' => 'Arctium lappa', 'f01_header1' => 'Arctium lappa', 'f01_header2' => 'Burdock', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/burdock', 'zkp_ID_t' => 'RECND393', 'zkp_recordID_cn' => '826573', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/burdock', 'f99_hidden' => '/herbals/burdock', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 28 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Butcher's Broom', 'f00_web_header2' => 'Ruscus aculeatus', 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'826432', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/butterbur', 'f99_hidden' => '/herbals/butterbur', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 30 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Calendula or Pot Marigold', 'f00_web_header2' => 'Calendula officinalis', 'f01_header1' => 'Calendula officinalis', 'f01_header2' => 'Marigold', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/marigold', 'zkp_ID_t' => 'RECND297', 'zkp_recordID_cn' => '826477', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/marigold', 'f99_hidden' => '/herbals/marigold', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 31 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Caraway', 'f00_web_header2' => 'Carum carvi', 'f01_header1' => 'Carum carvi', 'f01_header2' => 'Caraway', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/caraway', 'zkp_ID_t' => 'RECND364', 'zkp_recordID_cn' => '826544', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/caraway', 'f99_hidden' => '/herbals/caraway', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 32 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Castor oil', 'f00_web_header2' => 'Ricinus communis', 'f01_header1' => 'Ricinus communis', 'f01_header2' => 'Castor oil', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/castor-oil', 'zkp_ID_t' => 'RECND362', 'zkp_recordID_cn' => '826542', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/castor-oil', 'f99_hidden' => '/herbals/castor-oil', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 33 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Cat's Claw, Una DeGato', 'f00_web_header2' => 'Uncaria tomentosa', 'f01_header1' => 'Uncaria tomentosa / U. 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reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 36 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Cayenne', 'f00_web_header2' => 'Capsicum annuum', 'f01_header1' => 'Capsicum annuum', 'f01_header2' => 'Cayenne', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/cayenne', 'zkp_ID_t' => 'RECND256', 'zkp_recordID_cn' => '826436', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/cayenne', 'f99_hidden' => '/herbals/cayenne', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum 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'[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' } ] $pubmed_keyword = 'Silybum marianum' $pubmed_array = [] $record = object(Cake\ORM\Entity) { 'id' => (int) 198, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Milk Thistle', 'f00_web_header2' => 'Silybum marianum', 'f00_web_title' => 'Milk Thistle (Silybum marianum) - Benefits & Side-Effects', 'f01_header1' => 'Silybum marianum', 'f01_header2' => 'Milk Thistle', 'f01_header3' => 'Asteraceae', 'f01_header4' => 'Carduus marianus', 'f01_header5' => 'Asteraceae', 'f01_header6' => 'Asteraceae', 'f02_body_NHP_summary' => '<a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>Milk thistle</a> goes by many names including St. Mary's thistle, blessed thistle, and cardus marianus. To add to the confusion, it has two acceptable latin binomials (Silybum marianum and Carduus marianus). Most herbalists call it <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> (Silybum marianum) because of the milky white veins that run through its green leaves. <br> <br> Although coincidentally <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> has documented <a href="https://www.nhpassist.com//actions/galactagogue" style='text-decoration: none'>galactagogue</a> effects, its primary indication is for liver ailments. Most of the medicinal benefits focus on silymarin, which is a mixture of three flavonolignans (silibinin, silychristin, and silydianin). These polyphenols have significant <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> and <a href="https://www.nhpassist.com//actions/hepatoprotective" style='text-decoration: none'>hepatoprotective</a> effects that appear to support various detox pathways in the liver and stimulate liver regeneration to protects the liver from various toxins including alcohol and drugs. Silymarin stabilizes cell membranes, stimulates protein synthesis and accelerates liver regeneration to lower liver enzymes and reduce the progression to cirrhosis. Interestingly, silymarin may help in treating amanita mushroom poisoning, which currently there's no promising antidote. However, clinical trials on the benefits of <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> on viral <a href="https://www.nhpassist.com//conditions/hepatitis" style='text-decoration: none'>hepatitis</a> remain inconclusive at best. <br> <br> Silymarin could be an insulin sensitizer, and clinical trials show it improves glycemic control and lipid levels in diabetic patients. Also, people with non-alcohol <a href="https://www.nhpassist.com//conditions/fatty-liver" style='text-decoration: none'>fatty liver</a> disease (NAFLD), which <a href="https://www.nhpassist.com//conditions/weight-loss" style='text-decoration: none'>obesity</a> and <a href="https://www.nhpassist.com//conditions/diabetes-mellitus" style='text-decoration: none'>diabetes</a> are risk factors, benefit from taking <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> extracts. Because of its <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> effects, <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> may also aid help to prevent <a href="https://www.nhpassist.com//conditions/cholesterol" style='text-decoration: none'>atherosclerosis</a>. <br> <br> One particularly exciting area of research is the inhibitory effect that silymarin has on multi-drug resistant (MDR) pumps that are responsible for certain types of drug resistance. Further research is needed to determine if co-administration of silymarin with some antibiotics and <a href="https://www.nhpassist.com//actions/anticancer" style='text-decoration: none'>anticancer</a> drugs could increase their efficacy.', 'f02_body1' => 'Hepatobiliary <br> • various liver complaints <br> • jaundice <br> • viral <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> (<a href='/conditions/hepatitis' style='text-decoration: none'>HBV</a>, <a href='/conditions/hepatitis' style='text-decoration: none'>HCV</a>) <br> • drug-induced <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> <br> • non-alcoholic <a href='/conditions/fatty-liver' style='text-decoration: none'>fatty liver</a> disease (NAFLD) <br> <br> Gastrointestinal <br> • poor appetite <br> - poor digestion <br> - <a href='/conditions/indigestion' style='text-decoration: none'>dyspepsia</a> <br> - <a href='/conditions/hypochlorhydria' style='text-decoration: none'>hypochlorhydria</a> <br> • <a href='/conditions/stomach-ulcer' style='text-decoration: none'>peptic ulcers</a> <br> • ulcerative colitis <br> <br> Cardiovascular <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>hypercholesterolemia</a> <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>atherosclerosis</a> <br> <br> Metabolic <br> • type II <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> • diabetic nephropathy <br> • <a href='/conditions/gout' style='text-decoration: none'>gout</a> <br> <br> Female reproductive <br> • <a href='/conditions/lactation' style='text-decoration: none'>agalactia</a> (poor <a href='/conditions/lactation' style='text-decoration: none'>lactation</a>) <br> <br> Cancer <br> • chemotherapy - decreases hepatotoxicity and nephrotoxicity <br> <br> Dermatologic <br> • <a href='/conditions/acne-vulgaris' style='text-decoration: none'>acne</a> <a href='/conditions/rosacea' style='text-decoration: none'>rosacea</a> <br> <br> Other <br> • <a href='/conditions/mercury-poisoning' style='text-decoration: none'>mercury poisoning</a> <br> • obsessive-compulsive disorder (<a href='/conditions/obsessive-compulsive-disorder' style='text-decoration: none'>OCD</a> )', 'f02_body2' => '• <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatic' style='text-decoration: none'>Hepatic</a> <br> • Bitter (mild) <br> • <a href='/actions/galactagogue' style='text-decoration: none'>Galactagogue</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Antiulcerogenic</a>', 'f02_body3' => '• Flavolignans (E.g. Silymarin) <br> • Phenoilc Acids <br> • Sterols (E.g. Beta-Sitosterol )', 'f02_body4' => '', 'f02_body5' => '• Tincture (1:5 in 60% EtOH): 2-5 ml tid <br> • Liquid extract (1:1 in 25% EtOH): 2-6 ml tid <br> • Decoction (seeds): 1 tsp tid <br> • Standardized extract (70% silymarin): 600 mg/d <br> <br> Note: Leaf preparations are devoid of flavolignans, which are found in the seeds.', 'f02_body6' => 'Generally considered safe when used as indicated. <br> <br> Contra-Indications: <br> • gastritis & <a href='/conditions/stomach-ulcer' style='text-decoration: none'>stomach ulcers</a> <br> • obstructed gallbladder <br> <br> Caution: <br> • Asteraceae allergy: contains sesquiterpene lactones <br> <br> <a href='/conditions/pregnancy' style='text-decoration: none'>Pregnancy</a> & Lactaction: <br> • Considered safe', 'f02_body7' => 'Milk thistle may affect the drug metabolism by: <br> • CYP2C9 • may reduce clearance of drugs metabolized by this p450 <br> • Glucuronidation <br> <br> <br> Milk thistle is known to interact with the following drugs: <br> • deferiprone <br> • indinavir <br> • raloxifene <br> • simeprevir', 'f02_body8' => 'Barnes J, Anderson LA, Phillipson JD. Herbal Medicines, 3rd ed. London: Pharmaceutical Press, 2007. <br> <br> Bone K. Principles and Practice of Phytotherapy. Edinburgh: Churchill Livingstone, 2000. <br> <br> Bone K. A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient. St Louis, MO: Churchill Livingstone, 2003. <br> <br> Brinker F. The Toxicology of Botanical Medicines, 3rd ed. Sandy, Oregon: Eclectic Medical Publications, 2000. <br> <br> Felter HW, Lloyd JU. King's American Dispensatory. 1898. http://www.ibiblio.org/herbmed/eclectic/kings/main.html. Accessed: August 19, 2006. <br> <br> Hoffman D. Medical Herbalism. Rochester, Vermont: Healing Arts Press, 2003. <br> <br> Weiss RF. Herbal Medicine. Beaconsfield, England: Beaconsfield Publishers Ltd, 1988. <br> <br> Williamson EM, ed. Major Herbs of Ayurveda. 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To add to the confusion, it has two acceptable latin binomials (Silybum marianum and Carduus marianus). Most herbalists call it <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> (Silybum marianum) because of the milky white veins that run through its green leaves. <br> <br> Although coincidentally <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> has documented <a href='/actions/galactagogue' style='text-decoration: none'>galactagogue</a> effects, its primary indication is for liver ailments. Most of the medicinal benefits focus on silymarin, which is a mixture of three flavonolignans (silibinin, silychristin, and silydianin). These polyphenols have significant <a href='/actions/antioxidant' style='text-decoration: none'>antioxidant</a> and <a href='/actions/hepatoprotective' style='text-decoration: none'>hepatoprotective</a> effects that appear to support various detox pathways in the liver and stimulate liver regeneration to protects the liver from various toxins including alcohol and drugs. Silymarin stabilizes cell membranes, stimulates protein synthesis and accelerates liver regeneration to lower liver enzymes and reduce the progression to cirrhosis. Interestingly, silymarin may help in treating amanita mushroom poisoning, which currently there's no promising antidote. However, clinical trials on the benefits of <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> on viral <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> remain inconclusive at best. <br> <br> Silymarin could be an insulin sensitizer, and clinical trials show it improves glycemic control and lipid levels in diabetic patients. Also, people with non-alcohol <a href='/conditions/fatty-liver' style='text-decoration: none'>fatty liver</a> disease (NAFLD), which <a href='/conditions/weight-loss' style='text-decoration: none'>obesity</a> and <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> are risk factors, benefit from taking <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> extracts. Because of its <a href='/actions/antioxidant' style='text-decoration: none'>antioxidant</a> effects, <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> may also aid help to prevent <a href='/conditions/cholesterol' style='text-decoration: none'>atherosclerosis</a>. <br> <br> One particularly exciting area of research is the inhibitory effect that silymarin has on multi-drug resistant (MDR) pumps that are responsible for certain types of drug resistance. Further research is needed to determine if co-administration of silymarin with some antibiotics and <a href='/actions/anticancer' style='text-decoration: none'>anticancer</a> drugs could increase their efficacy.' ], '[virtual]' => [], '[hasErrors]' => false, '[errors]' => [], '[invalid]' => [], '[repository]' => 'Record' } $settings = [ 'paypal_email' => 'accounts@ndassist.com', 'paypal_url' => 'https://www.paypal.com/cgi-bin/webscr', 'paypal_price' => '20.00', 'paypal_tax' => '2.60', 'paypal_item_name' => 'Purchase NDAssist Access', 'paypal_currency_code' => 'CAD', 'contact_form_email' => 'info@ndassist.com', 'sender_email_address' => 'website@nhpassist.com', 'student' => 'student9903', 'holistic' => 'cannp99302', 'paypal_promo_code_price' => '20.00', 'comp_feature_price' => '20.00', 'paypal_comp_feature_name' => 'Display/Hide Companies and their Products', 'paypal_purchase_name' => 'Purchase NDAssist Herbal Rx application', 'item_1' => 'ND- Assist Website Access', 'item_2' => 'Herbal 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'f01_header3' => 'Asteraceae', 'f01_header4' => 'Carduus marianus', 'f01_header5' => 'Asteraceae', 'f01_header6' => 'Asteraceae', 'f02_body_NHP_summary' => '<a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>Milk thistle</a> goes by many names including St. Mary's thistle, blessed thistle, and cardus marianus. To add to the confusion, it has two acceptable latin binomials (Silybum marianum and Carduus marianus). Most herbalists call it <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> (Silybum marianum) because of the milky white veins that run through its green leaves. <br> <br> Although coincidentally <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> has documented <a href="https://www.nhpassist.com//actions/galactagogue" style='text-decoration: none'>galactagogue</a> effects, its primary indication is for liver ailments. Most of the medicinal benefits focus on silymarin, which is a mixture of three flavonolignans (silibinin, silychristin, and silydianin). These polyphenols have significant <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> and <a href="https://www.nhpassist.com//actions/hepatoprotective" style='text-decoration: none'>hepatoprotective</a> effects that appear to support various detox pathways in the liver and stimulate liver regeneration to protects the liver from various toxins including alcohol and drugs. Silymarin stabilizes cell membranes, stimulates protein synthesis and accelerates liver regeneration to lower liver enzymes and reduce the progression to cirrhosis. Interestingly, silymarin may help in treating amanita mushroom poisoning, which currently there's no promising antidote. However, clinical trials on the benefits of <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> on viral <a href="https://www.nhpassist.com//conditions/hepatitis" style='text-decoration: none'>hepatitis</a> remain inconclusive at best. <br> <br> Silymarin could be an insulin sensitizer, and clinical trials show it improves glycemic control and lipid levels in diabetic patients. Also, people with non-alcohol <a href="https://www.nhpassist.com//conditions/fatty-liver" style='text-decoration: none'>fatty liver</a> disease (NAFLD), which <a href="https://www.nhpassist.com//conditions/weight-loss" style='text-decoration: none'>obesity</a> and <a href="https://www.nhpassist.com//conditions/diabetes-mellitus" style='text-decoration: none'>diabetes</a> are risk factors, benefit from taking <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> extracts. Because of its <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> effects, <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> may also aid help to prevent <a href="https://www.nhpassist.com//conditions/cholesterol" style='text-decoration: none'>atherosclerosis</a>. <br> <br> One particularly exciting area of research is the inhibitory effect that silymarin has on multi-drug resistant (MDR) pumps that are responsible for certain types of drug resistance. Further research is needed to determine if co-administration of silymarin with some antibiotics and <a href="https://www.nhpassist.com//actions/anticancer" style='text-decoration: none'>anticancer</a> drugs could increase their efficacy.', 'f02_body1' => 'Hepatobiliary <br> • various liver complaints <br> • jaundice <br> • viral <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> (<a href='/conditions/hepatitis' style='text-decoration: none'>HBV</a>, <a href='/conditions/hepatitis' style='text-decoration: none'>HCV</a>) <br> • drug-induced <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> <br> • non-alcoholic <a href='/conditions/fatty-liver' style='text-decoration: none'>fatty liver</a> disease (NAFLD) <br> <br> Gastrointestinal <br> • poor appetite <br> - poor digestion <br> - <a href='/conditions/indigestion' style='text-decoration: none'>dyspepsia</a> <br> - <a href='/conditions/hypochlorhydria' style='text-decoration: none'>hypochlorhydria</a> <br> • <a href='/conditions/stomach-ulcer' style='text-decoration: none'>peptic ulcers</a> <br> • ulcerative colitis <br> <br> Cardiovascular <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>hypercholesterolemia</a> <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>atherosclerosis</a> <br> <br> Metabolic <br> • type II <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> • diabetic nephropathy <br> • <a href='/conditions/gout' style='text-decoration: none'>gout</a> <br> <br> Female reproductive <br> • <a href='/conditions/lactation' style='text-decoration: none'>agalactia</a> (poor <a href='/conditions/lactation' style='text-decoration: none'>lactation</a>) <br> <br> Cancer <br> • chemotherapy - decreases hepatotoxicity and nephrotoxicity <br> <br> Dermatologic <br> • <a href='/conditions/acne-vulgaris' style='text-decoration: none'>acne</a> <a href='/conditions/rosacea' style='text-decoration: none'>rosacea</a> <br> <br> Other <br> • <a href='/conditions/mercury-poisoning' style='text-decoration: none'>mercury poisoning</a> <br> • obsessive-compulsive disorder (<a href='/conditions/obsessive-compulsive-disorder' style='text-decoration: none'>OCD</a> )', 'f02_body2' => '• <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatic' style='text-decoration: none'>Hepatic</a> <br> • Bitter (mild) <br> • <a href='/actions/galactagogue' style='text-decoration: none'>Galactagogue</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Antiulcerogenic</a>', 'f02_body3' => '• Flavolignans (E.g. Silymarin) <br> • Phenoilc Acids <br> • Sterols (E.g. Beta-Sitosterol )', 'f02_body4' => '', 'f02_body5' => '• Tincture (1:5 in 60% EtOH): 2-5 ml tid <br> • Liquid extract (1:1 in 25% EtOH): 2-6 ml tid <br> • Decoction (seeds): 1 tsp tid <br> • Standardized extract (70% silymarin): 600 mg/d <br> <br> Note: Leaf preparations are devoid of flavolignans, which are found in the seeds.', 'f02_body6' => 'Generally considered safe when used as indicated. <br> <br> Contra-Indications: <br> • gastritis & <a href='/conditions/stomach-ulcer' style='text-decoration: none'>stomach ulcers</a> <br> • obstructed gallbladder <br> <br> Caution: <br> • Asteraceae allergy: contains sesquiterpene lactones <br> <br> <a href='/conditions/pregnancy' style='text-decoration: none'>Pregnancy</a> & Lactaction: <br> • Considered safe', 'f02_body7' => 'Milk thistle may affect the drug metabolism by: <br> • CYP2C9 • may reduce clearance of drugs metabolized by this p450 <br> • Glucuronidation <br> <br> <br> Milk thistle is known to interact with the following drugs: <br> • deferiprone <br> • indinavir <br> • raloxifene <br> • simeprevir', 'f02_body8' => 'Barnes J, Anderson LA, Phillipson JD. Herbal Medicines, 3rd ed. London: Pharmaceutical Press, 2007. <br> <br> Bone K. Principles and Practice of Phytotherapy. Edinburgh: Churchill Livingstone, 2000. <br> <br> Bone K. A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient. St Louis, MO: Churchill Livingstone, 2003. <br> <br> Brinker F. The Toxicology of Botanical Medicines, 3rd ed. Sandy, Oregon: Eclectic Medical Publications, 2000. <br> <br> Felter HW, Lloyd JU. King's American Dispensatory. 1898. http://www.ibiblio.org/herbmed/eclectic/kings/main.html. Accessed: August 19, 2006. <br> <br> Hoffman D. Medical Herbalism. Rochester, Vermont: Healing Arts Press, 2003. <br> <br> Weiss RF. Herbal Medicine. Beaconsfield, England: Beaconsfield Publishers Ltd, 1988. <br> <br> Williamson EM, ed. Major Herbs of Ayurveda. Edinburgh: Churchill Livingstone, 2002', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/milk-thistle', 'f03_web_image_URL_large' => 'milk-thistle-silybum-marianum', 'f01_header0_web_buy_script' => '', 'f03_web_store_link' => '', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/milk-thistle', 'f04_keywordsPaid' => 'Silybum marianum Milk Thistle', 'f05_significance_n' => '', 'f98_shortURL' => 'http://bit.ly/144NWAE', 'zi_sorter_un' => '', 'z_hidden_b' => '0', 'z_isFilter_b' => '0', 'z_locked_b' => '0', 'f99_hidden' => '/herbals/milk-thistle', 'zkf_oldID_t' => '2v5_00686', 'zkp_ID_t' => 'RECND352', 'zkp_recordID_cn' => '826532', 'f001_country' => '', 'f001_vendor' => '', 'f03_image1_size_cn' => '', 'f04_keywordText_t10' => '• jaundice <br> • viral hepatitis (HBV, HCV) <br> • drug-induced hepatitis <br> • non-alcoholic fatty liver disease (NAFLD) <br> • liver disease ', 'Matt_exp_webviewer' => null, 'SP_foundCount_un' => '301', 'z_log_b' => '0', 'za_created_m' => 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'[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' } ] $pubmed_keyword = 'Silybum marianum' $pubmed_array = [] $record = object(Cake\ORM\Entity) { 'id' => (int) 198, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Milk Thistle', 'f00_web_header2' => 'Silybum marianum', 'f00_web_title' => 'Milk Thistle (Silybum marianum) - Benefits & Side-Effects', 'f01_header1' => 'Silybum marianum', 'f01_header2' => 'Milk Thistle', 'f01_header3' => 'Asteraceae', 'f01_header4' => 'Carduus marianus', 'f01_header5' => 'Asteraceae', 'f01_header6' => 'Asteraceae', 'f02_body_NHP_summary' => '<a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>Milk thistle</a> goes by many names including St. Mary's thistle, blessed thistle, and cardus marianus. To add to the confusion, it has two acceptable latin binomials (Silybum marianum and Carduus marianus). Most herbalists call it <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> (Silybum marianum) because of the milky white veins that run through its green leaves. <br> <br> Although coincidentally <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> has documented <a href="https://www.nhpassist.com//actions/galactagogue" style='text-decoration: none'>galactagogue</a> effects, its primary indication is for liver ailments. Most of the medicinal benefits focus on silymarin, which is a mixture of three flavonolignans (silibinin, silychristin, and silydianin). These polyphenols have significant <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> and <a href="https://www.nhpassist.com//actions/hepatoprotective" style='text-decoration: none'>hepatoprotective</a> effects that appear to support various detox pathways in the liver and stimulate liver regeneration to protects the liver from various toxins including alcohol and drugs. Silymarin stabilizes cell membranes, stimulates protein synthesis and accelerates liver regeneration to lower liver enzymes and reduce the progression to cirrhosis. Interestingly, silymarin may help in treating amanita mushroom poisoning, which currently there's no promising antidote. However, clinical trials on the benefits of <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> on viral <a href="https://www.nhpassist.com//conditions/hepatitis" style='text-decoration: none'>hepatitis</a> remain inconclusive at best. <br> <br> Silymarin could be an insulin sensitizer, and clinical trials show it improves glycemic control and lipid levels in diabetic patients. Also, people with non-alcohol <a href="https://www.nhpassist.com//conditions/fatty-liver" style='text-decoration: none'>fatty liver</a> disease (NAFLD), which <a href="https://www.nhpassist.com//conditions/weight-loss" style='text-decoration: none'>obesity</a> and <a href="https://www.nhpassist.com//conditions/diabetes-mellitus" style='text-decoration: none'>diabetes</a> are risk factors, benefit from taking <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> extracts. Because of its <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> effects, <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> may also aid help to prevent <a href="https://www.nhpassist.com//conditions/cholesterol" style='text-decoration: none'>atherosclerosis</a>. <br> <br> One particularly exciting area of research is the inhibitory effect that silymarin has on multi-drug resistant (MDR) pumps that are responsible for certain types of drug resistance. Further research is needed to determine if co-administration of silymarin with some antibiotics and <a href="https://www.nhpassist.com//actions/anticancer" style='text-decoration: none'>anticancer</a> drugs could increase their efficacy.', 'f02_body1' => 'Hepatobiliary <br> • various liver complaints <br> • jaundice <br> • viral <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> (<a href='/conditions/hepatitis' style='text-decoration: none'>HBV</a>, <a href='/conditions/hepatitis' style='text-decoration: none'>HCV</a>) <br> • drug-induced <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> <br> • non-alcoholic <a href='/conditions/fatty-liver' style='text-decoration: none'>fatty liver</a> disease (NAFLD) <br> <br> Gastrointestinal <br> • poor appetite <br> - poor digestion <br> - <a href='/conditions/indigestion' style='text-decoration: none'>dyspepsia</a> <br> - <a href='/conditions/hypochlorhydria' style='text-decoration: none'>hypochlorhydria</a> <br> • <a href='/conditions/stomach-ulcer' style='text-decoration: none'>peptic ulcers</a> <br> • ulcerative colitis <br> <br> Cardiovascular <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>hypercholesterolemia</a> <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>atherosclerosis</a> <br> <br> Metabolic <br> • type II <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> • diabetic nephropathy <br> • <a href='/conditions/gout' style='text-decoration: none'>gout</a> <br> <br> Female reproductive <br> • <a href='/conditions/lactation' style='text-decoration: none'>agalactia</a> (poor <a href='/conditions/lactation' style='text-decoration: none'>lactation</a>) <br> <br> Cancer <br> • chemotherapy - decreases hepatotoxicity and nephrotoxicity <br> <br> Dermatologic <br> • <a href='/conditions/acne-vulgaris' style='text-decoration: none'>acne</a> <a href='/conditions/rosacea' style='text-decoration: none'>rosacea</a> <br> <br> Other <br> • <a href='/conditions/mercury-poisoning' style='text-decoration: none'>mercury poisoning</a> <br> • obsessive-compulsive disorder (<a href='/conditions/obsessive-compulsive-disorder' style='text-decoration: none'>OCD</a> )', 'f02_body2' => '• <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatic' style='text-decoration: none'>Hepatic</a> <br> • Bitter (mild) <br> • <a href='/actions/galactagogue' style='text-decoration: none'>Galactagogue</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Antiulcerogenic</a>', 'f02_body3' => '• Flavolignans (E.g. Silymarin) <br> • Phenoilc Acids <br> • Sterols (E.g. Beta-Sitosterol )', 'f02_body4' => '', 'f02_body5' => '• Tincture (1:5 in 60% EtOH): 2-5 ml tid <br> • Liquid extract (1:1 in 25% EtOH): 2-6 ml tid <br> • Decoction (seeds): 1 tsp tid <br> • Standardized extract (70% silymarin): 600 mg/d <br> <br> Note: Leaf preparations are devoid of flavolignans, which are found in the seeds.', 'f02_body6' => 'Generally considered safe when used as indicated. <br> <br> Contra-Indications: <br> • gastritis & <a href='/conditions/stomach-ulcer' style='text-decoration: none'>stomach ulcers</a> <br> • obstructed gallbladder <br> <br> Caution: <br> • Asteraceae allergy: contains sesquiterpene lactones <br> <br> <a href='/conditions/pregnancy' style='text-decoration: none'>Pregnancy</a> & Lactaction: <br> • Considered safe', 'f02_body7' => 'Milk thistle may affect the drug metabolism by: <br> • CYP2C9 • may reduce clearance of drugs metabolized by this p450 <br> • Glucuronidation <br> <br> <br> Milk thistle is known to interact with the following drugs: <br> • deferiprone <br> • indinavir <br> • raloxifene <br> • simeprevir', 'f02_body8' => 'Barnes J, Anderson LA, Phillipson JD. Herbal Medicines, 3rd ed. London: Pharmaceutical Press, 2007. <br> <br> Bone K. Principles and Practice of Phytotherapy. Edinburgh: Churchill Livingstone, 2000. <br> <br> Bone K. A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient. St Louis, MO: Churchill Livingstone, 2003. <br> <br> Brinker F. The Toxicology of Botanical Medicines, 3rd ed. Sandy, Oregon: Eclectic Medical Publications, 2000. <br> <br> Felter HW, Lloyd JU. King's American Dispensatory. 1898. http://www.ibiblio.org/herbmed/eclectic/kings/main.html. Accessed: August 19, 2006. <br> <br> Hoffman D. Medical Herbalism. Rochester, Vermont: Healing Arts Press, 2003. <br> <br> Weiss RF. Herbal Medicine. Beaconsfield, England: Beaconsfield Publishers Ltd, 1988. <br> <br> Williamson EM, ed. Major Herbs of Ayurveda. 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To add to the confusion, it has two acceptable latin binomials (Silybum marianum and Carduus marianus). Most herbalists call it <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> (Silybum marianum) because of the milky white veins that run through its green leaves. <br> <br> Although coincidentally <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> has documented <a href='/actions/galactagogue' style='text-decoration: none'>galactagogue</a> effects, its primary indication is for liver ailments. Most of the medicinal benefits focus on silymarin, which is a mixture of three flavonolignans (silibinin, silychristin, and silydianin). These polyphenols have significant <a href='/actions/antioxidant' style='text-decoration: none'>antioxidant</a> and <a href='/actions/hepatoprotective' style='text-decoration: none'>hepatoprotective</a> effects that appear to support various detox pathways in the liver and stimulate liver regeneration to protects the liver from various toxins including alcohol and drugs. Silymarin stabilizes cell membranes, stimulates protein synthesis and accelerates liver regeneration to lower liver enzymes and reduce the progression to cirrhosis. Interestingly, silymarin may help in treating amanita mushroom poisoning, which currently there's no promising antidote. However, clinical trials on the benefits of <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> on viral <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> remain inconclusive at best. <br> <br> Silymarin could be an insulin sensitizer, and clinical trials show it improves glycemic control and lipid levels in diabetic patients. Also, people with non-alcohol <a href='/conditions/fatty-liver' style='text-decoration: none'>fatty liver</a> disease (NAFLD), which <a href='/conditions/weight-loss' style='text-decoration: none'>obesity</a> and <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> are risk factors, benefit from taking <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> extracts. Because of its <a href='/actions/antioxidant' style='text-decoration: none'>antioxidant</a> effects, <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> may also aid help to prevent <a href='/conditions/cholesterol' style='text-decoration: none'>atherosclerosis</a>. <br> <br> One particularly exciting area of research is the inhibitory effect that silymarin has on multi-drug resistant (MDR) pumps that are responsible for certain types of drug resistance. 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• Flavolignans (E.g. Silymarin)
• Phenoilc Acids
• Sterols (E.g. Beta-Sitosterol )
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'f01_header3' => 'Asteraceae', 'f01_header4' => 'Carduus marianus', 'f01_header5' => 'Asteraceae', 'f01_header6' => 'Asteraceae', 'f02_body_NHP_summary' => '<a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>Milk thistle</a> goes by many names including St. Mary's thistle, blessed thistle, and cardus marianus. To add to the confusion, it has two acceptable latin binomials (Silybum marianum and Carduus marianus). Most herbalists call it <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> (Silybum marianum) because of the milky white veins that run through its green leaves. <br> <br> Although coincidentally <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> has documented <a href="https://www.nhpassist.com//actions/galactagogue" style='text-decoration: none'>galactagogue</a> effects, its primary indication is for liver ailments. Most of the medicinal benefits focus on silymarin, which is a mixture of three flavonolignans (silibinin, silychristin, and silydianin). These polyphenols have significant <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> and <a href="https://www.nhpassist.com//actions/hepatoprotective" style='text-decoration: none'>hepatoprotective</a> effects that appear to support various detox pathways in the liver and stimulate liver regeneration to protects the liver from various toxins including alcohol and drugs. Silymarin stabilizes cell membranes, stimulates protein synthesis and accelerates liver regeneration to lower liver enzymes and reduce the progression to cirrhosis. Interestingly, silymarin may help in treating amanita mushroom poisoning, which currently there's no promising antidote. However, clinical trials on the benefits of <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> on viral <a href="https://www.nhpassist.com//conditions/hepatitis" style='text-decoration: none'>hepatitis</a> remain inconclusive at best. <br> <br> Silymarin could be an insulin sensitizer, and clinical trials show it improves glycemic control and lipid levels in diabetic patients. Also, people with non-alcohol <a href="https://www.nhpassist.com//conditions/fatty-liver" style='text-decoration: none'>fatty liver</a> disease (NAFLD), which <a href="https://www.nhpassist.com//conditions/weight-loss" style='text-decoration: none'>obesity</a> and <a href="https://www.nhpassist.com//conditions/diabetes-mellitus" style='text-decoration: none'>diabetes</a> are risk factors, benefit from taking <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> extracts. Because of its <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> effects, <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> may also aid help to prevent <a href="https://www.nhpassist.com//conditions/cholesterol" style='text-decoration: none'>atherosclerosis</a>. <br> <br> One particularly exciting area of research is the inhibitory effect that silymarin has on multi-drug resistant (MDR) pumps that are responsible for certain types of drug resistance. Further research is needed to determine if co-administration of silymarin with some antibiotics and <a href="https://www.nhpassist.com//actions/anticancer" style='text-decoration: none'>anticancer</a> drugs could increase their efficacy.', 'f02_body1' => 'Hepatobiliary <br> • various liver complaints <br> • jaundice <br> • viral <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> (<a href='/conditions/hepatitis' style='text-decoration: none'>HBV</a>, <a href='/conditions/hepatitis' style='text-decoration: none'>HCV</a>) <br> • drug-induced <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> <br> • non-alcoholic <a href='/conditions/fatty-liver' style='text-decoration: none'>fatty liver</a> disease (NAFLD) <br> <br> Gastrointestinal <br> • poor appetite <br> - poor digestion <br> - <a href='/conditions/indigestion' style='text-decoration: none'>dyspepsia</a> <br> - <a href='/conditions/hypochlorhydria' style='text-decoration: none'>hypochlorhydria</a> <br> • <a href='/conditions/stomach-ulcer' style='text-decoration: none'>peptic ulcers</a> <br> • ulcerative colitis <br> <br> Cardiovascular <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>hypercholesterolemia</a> <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>atherosclerosis</a> <br> <br> Metabolic <br> • type II <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> • diabetic nephropathy <br> • <a href='/conditions/gout' style='text-decoration: none'>gout</a> <br> <br> Female reproductive <br> • <a href='/conditions/lactation' style='text-decoration: none'>agalactia</a> (poor <a href='/conditions/lactation' style='text-decoration: none'>lactation</a>) <br> <br> Cancer <br> • chemotherapy - decreases hepatotoxicity and nephrotoxicity <br> <br> Dermatologic <br> • <a href='/conditions/acne-vulgaris' style='text-decoration: none'>acne</a> <a href='/conditions/rosacea' style='text-decoration: none'>rosacea</a> <br> <br> Other <br> • <a href='/conditions/mercury-poisoning' style='text-decoration: none'>mercury poisoning</a> <br> • obsessive-compulsive disorder (<a href='/conditions/obsessive-compulsive-disorder' style='text-decoration: none'>OCD</a> )', 'f02_body2' => '• <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatic' style='text-decoration: none'>Hepatic</a> <br> • Bitter (mild) <br> • <a href='/actions/galactagogue' style='text-decoration: none'>Galactagogue</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Antiulcerogenic</a>', 'f02_body3' => '• Flavolignans (E.g. Silymarin) <br> • Phenoilc Acids <br> • Sterols (E.g. Beta-Sitosterol )', 'f02_body4' => '', 'f02_body5' => '• Tincture (1:5 in 60% EtOH): 2-5 ml tid <br> • Liquid extract (1:1 in 25% EtOH): 2-6 ml tid <br> • Decoction (seeds): 1 tsp tid <br> • Standardized extract (70% silymarin): 600 mg/d <br> <br> Note: Leaf preparations are devoid of flavolignans, which are found in the seeds.', 'f02_body6' => 'Generally considered safe when used as indicated. <br> <br> Contra-Indications: <br> • gastritis & <a href='/conditions/stomach-ulcer' style='text-decoration: none'>stomach ulcers</a> <br> • obstructed gallbladder <br> <br> Caution: <br> • Asteraceae allergy: contains sesquiterpene lactones <br> <br> <a href='/conditions/pregnancy' style='text-decoration: none'>Pregnancy</a> & Lactaction: <br> • Considered safe', 'f02_body7' => 'Milk thistle may affect the drug metabolism by: <br> • CYP2C9 • may reduce clearance of drugs metabolized by this p450 <br> • Glucuronidation <br> <br> <br> Milk thistle is known to interact with the following drugs: <br> • deferiprone <br> • indinavir <br> • raloxifene <br> • simeprevir', 'f02_body8' => 'Barnes J, Anderson LA, Phillipson JD. Herbal Medicines, 3rd ed. London: Pharmaceutical Press, 2007. <br> <br> Bone K. Principles and Practice of Phytotherapy. Edinburgh: Churchill Livingstone, 2000. <br> <br> Bone K. A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient. St Louis, MO: Churchill Livingstone, 2003. <br> <br> Brinker F. The Toxicology of Botanical Medicines, 3rd ed. Sandy, Oregon: Eclectic Medical Publications, 2000. <br> <br> Felter HW, Lloyd JU. King's American Dispensatory. 1898. http://www.ibiblio.org/herbmed/eclectic/kings/main.html. Accessed: August 19, 2006. <br> <br> Hoffman D. Medical Herbalism. Rochester, Vermont: Healing Arts Press, 2003. <br> <br> Weiss RF. Herbal Medicine. Beaconsfield, England: Beaconsfield Publishers Ltd, 1988. <br> <br> Williamson EM, ed. Major Herbs of Ayurveda. 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'[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 16 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Bilberry (Europe), huckleberry & blueberry (North America )', 'f00_web_header2' => 'Vaccinium myrtillus', 'f01_header1' => 'Vaccinium myrtillus', 'f01_header2' => 'Bilberry (Europe), huckleberry & blueberry (North America )', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/bilberry-europe-huckleberry-&-blueberry-north-america', 'zkp_ID_t' => 'RECND247', 'zkp_recordID_cn' => '826427', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/bilberry-europe-huckleberry-&-blueberry-north-america', 'f99_hidden' => '/herbals/bilberry-europe-huckleberry-&-blueberry-north-america', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 17 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Bitter Melon, Karela', 'f00_web_header2' => 'Momordica charantia', 'f01_header1' => 'Momordica charantia', 'f01_header2' => 'Bitter Melon, Karela', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/bitter-melon-karela', 'zkp_ID_t' => 'RECND394', 'zkp_recordID_cn' => '826574', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/bitter-melon-karela', 'f99_hidden' => '/herbals/bitter-melon-karela', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 18 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Black Cohosh', 'f00_web_header2' => 'Cimicifuga racemosa', 'f01_header1' => 'Cimicifuga racemosa', 'f01_header2' => 'Black Cohosh', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/black-cohosh', 'zkp_ID_t' => 'RECND381', 'zkp_recordID_cn' => '826561', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/black-cohosh', 'f99_hidden' => '/herbals/black-cohosh', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 19 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Black Walnut', 'f00_web_header2' => 'Juglans nigra', 'f01_header1' => 'Juglans nigra', 'f01_header2' => 'Black Walnut', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/black-walnut', 'zkp_ID_t' => 'RECND379', 'zkp_recordID_cn' => '826559', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/black-walnut', 'f99_hidden' => '/herbals/black-walnut', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 20 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Bloodroot', 'f00_web_header2' => 'Sanguinaria canadensis', 'f01_header1' => 'Sanguinaria canadensis', 'f01_header2' => 'Bloodroot', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/bloodroot', 'zkp_ID_t' => 'RECND248', 'zkp_recordID_cn' => '826428', 'f03_imageURL_t' => 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(int) 23 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Bogbean', 'f00_web_header2' => 'Buckbean', 'f01_header1' => 'Menyanthes trifoliata', 'f01_header2' => 'Bogbean', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/bogbean', 'zkp_ID_t' => 'REC109add9e526752', 'zkp_recordID_cn' => '830894', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/bogbean', 'f99_hidden' => '/herbals/bogbean', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 24 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Boldo', 'f00_web_header2' => 'Peumus boldus', 'f01_header1' => 'Peumus boldus', 'f01_header2' => 'Boldo', 'f03_web_image_URL' => 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reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 26 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Buchu', 'f00_web_header2' => 'Agathosma betulina', 'f01_header1' => 'Agathosma betulina', 'f01_header2' => 'Buchu & Barosma', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/buchu-&-barosma', 'zkp_ID_t' => 'RECND251', 'zkp_recordID_cn' => '826431', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/buchu-&-barosma', 'f99_hidden' => '/herbals/buchu-barosma', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 27 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Burdock', 'f00_web_header2' => 'Arctium lappa', 'f01_header1' => 'Arctium lappa', 'f01_header2' => 'Burdock', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/burdock', 'zkp_ID_t' => 'RECND393', 'zkp_recordID_cn' => '826573', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/burdock', 'f99_hidden' => '/herbals/burdock', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 28 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Butcher's Broom', 'f00_web_header2' => 'Ruscus aculeatus', 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[[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 31 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Caraway', 'f00_web_header2' => 'Carum carvi', 'f01_header1' => 'Carum carvi', 'f01_header2' => 'Caraway', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/caraway', 'zkp_ID_t' => 'RECND364', 'zkp_recordID_cn' => '826544', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/caraway', 'f99_hidden' => '/herbals/caraway', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 32 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Castor oil', 'f00_web_header2' => 'Ricinus communis', 'f01_header1' => 'Ricinus communis', 'f01_header2' => 'Castor oil', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/castor-oil', 'zkp_ID_t' => 'RECND362', 'zkp_recordID_cn' => '826542', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/castor-oil', 'f99_hidden' => '/herbals/castor-oil', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 33 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Cat's Claw, Una DeGato', 'f00_web_header2' => 'Uncaria tomentosa', 'f01_header1' => 'Uncaria tomentosa / U. 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depth reached]], '[repository]' => 'Record' }, (int) 37 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Cedar (Yellow )', 'f00_web_header2' => 'Thuja occidentalis', 'f01_header1' => 'Thuja occidentalis', 'f01_header2' => 'Yellow cedar', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/yellow-cedar', 'zkp_ID_t' => 'RECND325', 'zkp_recordID_cn' => '826505', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/yellow-cedar', 'f99_hidden' => '/herbals/yellow-cedar', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 38 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Centaury', 'f00_web_header2' => 'Centaurium erythraea', 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'[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' } ] $pubmed_keyword = 'Silybum marianum' $pubmed_array = [] $record = object(Cake\ORM\Entity) { 'id' => (int) 198, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Milk Thistle', 'f00_web_header2' => 'Silybum marianum', 'f00_web_title' => 'Milk Thistle (Silybum marianum) - Benefits & Side-Effects', 'f01_header1' => 'Silybum marianum', 'f01_header2' => 'Milk Thistle', 'f01_header3' => 'Asteraceae', 'f01_header4' => 'Carduus marianus', 'f01_header5' => 'Asteraceae', 'f01_header6' => 'Asteraceae', 'f02_body_NHP_summary' => '<a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>Milk thistle</a> goes by many names including St. Mary's thistle, blessed thistle, and cardus marianus. To add to the confusion, it has two acceptable latin binomials (Silybum marianum and Carduus marianus). Most herbalists call it <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> (Silybum marianum) because of the milky white veins that run through its green leaves. <br> <br> Although coincidentally <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> has documented <a href="https://www.nhpassist.com//actions/galactagogue" style='text-decoration: none'>galactagogue</a> effects, its primary indication is for liver ailments. Most of the medicinal benefits focus on silymarin, which is a mixture of three flavonolignans (silibinin, silychristin, and silydianin). These polyphenols have significant <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> and <a href="https://www.nhpassist.com//actions/hepatoprotective" style='text-decoration: none'>hepatoprotective</a> effects that appear to support various detox pathways in the liver and stimulate liver regeneration to protects the liver from various toxins including alcohol and drugs. Silymarin stabilizes cell membranes, stimulates protein synthesis and accelerates liver regeneration to lower liver enzymes and reduce the progression to cirrhosis. Interestingly, silymarin may help in treating amanita mushroom poisoning, which currently there's no promising antidote. However, clinical trials on the benefits of <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> on viral <a href="https://www.nhpassist.com//conditions/hepatitis" style='text-decoration: none'>hepatitis</a> remain inconclusive at best. <br> <br> Silymarin could be an insulin sensitizer, and clinical trials show it improves glycemic control and lipid levels in diabetic patients. Also, people with non-alcohol <a href="https://www.nhpassist.com//conditions/fatty-liver" style='text-decoration: none'>fatty liver</a> disease (NAFLD), which <a href="https://www.nhpassist.com//conditions/weight-loss" style='text-decoration: none'>obesity</a> and <a href="https://www.nhpassist.com//conditions/diabetes-mellitus" style='text-decoration: none'>diabetes</a> are risk factors, benefit from taking <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> extracts. Because of its <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> effects, <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> may also aid help to prevent <a href="https://www.nhpassist.com//conditions/cholesterol" style='text-decoration: none'>atherosclerosis</a>. <br> <br> One particularly exciting area of research is the inhibitory effect that silymarin has on multi-drug resistant (MDR) pumps that are responsible for certain types of drug resistance. Further research is needed to determine if co-administration of silymarin with some antibiotics and <a href="https://www.nhpassist.com//actions/anticancer" style='text-decoration: none'>anticancer</a> drugs could increase their efficacy.', 'f02_body1' => 'Hepatobiliary <br> • various liver complaints <br> • jaundice <br> • viral <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> (<a href='/conditions/hepatitis' style='text-decoration: none'>HBV</a>, <a href='/conditions/hepatitis' style='text-decoration: none'>HCV</a>) <br> • drug-induced <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> <br> • non-alcoholic <a href='/conditions/fatty-liver' style='text-decoration: none'>fatty liver</a> disease (NAFLD) <br> <br> Gastrointestinal <br> • poor appetite <br> - poor digestion <br> - <a href='/conditions/indigestion' style='text-decoration: none'>dyspepsia</a> <br> - <a href='/conditions/hypochlorhydria' style='text-decoration: none'>hypochlorhydria</a> <br> • <a href='/conditions/stomach-ulcer' style='text-decoration: none'>peptic ulcers</a> <br> • ulcerative colitis <br> <br> Cardiovascular <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>hypercholesterolemia</a> <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>atherosclerosis</a> <br> <br> Metabolic <br> • type II <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> • diabetic nephropathy <br> • <a href='/conditions/gout' style='text-decoration: none'>gout</a> <br> <br> Female reproductive <br> • <a href='/conditions/lactation' style='text-decoration: none'>agalactia</a> (poor <a href='/conditions/lactation' style='text-decoration: none'>lactation</a>) <br> <br> Cancer <br> • chemotherapy - decreases hepatotoxicity and nephrotoxicity <br> <br> Dermatologic <br> • <a href='/conditions/acne-vulgaris' style='text-decoration: none'>acne</a> <a href='/conditions/rosacea' style='text-decoration: none'>rosacea</a> <br> <br> Other <br> • <a href='/conditions/mercury-poisoning' style='text-decoration: none'>mercury poisoning</a> <br> • obsessive-compulsive disorder (<a href='/conditions/obsessive-compulsive-disorder' style='text-decoration: none'>OCD</a> )', 'f02_body2' => '• <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatic' style='text-decoration: none'>Hepatic</a> <br> • Bitter (mild) <br> • <a href='/actions/galactagogue' style='text-decoration: none'>Galactagogue</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Antiulcerogenic</a>', 'f02_body3' => '• Flavolignans (E.g. Silymarin) <br> • Phenoilc Acids <br> • Sterols (E.g. Beta-Sitosterol )', 'f02_body4' => '', 'f02_body5' => '• Tincture (1:5 in 60% EtOH): 2-5 ml tid <br> • Liquid extract (1:1 in 25% EtOH): 2-6 ml tid <br> • Decoction (seeds): 1 tsp tid <br> • Standardized extract (70% silymarin): 600 mg/d <br> <br> Note: Leaf preparations are devoid of flavolignans, which are found in the seeds.', 'f02_body6' => 'Generally considered safe when used as indicated. <br> <br> Contra-Indications: <br> • gastritis & <a href='/conditions/stomach-ulcer' style='text-decoration: none'>stomach ulcers</a> <br> • obstructed gallbladder <br> <br> Caution: <br> • Asteraceae allergy: contains sesquiterpene lactones <br> <br> <a href='/conditions/pregnancy' style='text-decoration: none'>Pregnancy</a> & Lactaction: <br> • Considered safe', 'f02_body7' => 'Milk thistle may affect the drug metabolism by: <br> • CYP2C9 • may reduce clearance of drugs metabolized by this p450 <br> • Glucuronidation <br> <br> <br> Milk thistle is known to interact with the following drugs: <br> • deferiprone <br> • indinavir <br> • raloxifene <br> • simeprevir', 'f02_body8' => 'Barnes J, Anderson LA, Phillipson JD. Herbal Medicines, 3rd ed. London: Pharmaceutical Press, 2007. <br> <br> Bone K. Principles and Practice of Phytotherapy. Edinburgh: Churchill Livingstone, 2000. <br> <br> Bone K. A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient. St Louis, MO: Churchill Livingstone, 2003. <br> <br> Brinker F. The Toxicology of Botanical Medicines, 3rd ed. Sandy, Oregon: Eclectic Medical Publications, 2000. <br> <br> Felter HW, Lloyd JU. King's American Dispensatory. 1898. http://www.ibiblio.org/herbmed/eclectic/kings/main.html. Accessed: August 19, 2006. <br> <br> Hoffman D. Medical Herbalism. Rochester, Vermont: Healing Arts Press, 2003. <br> <br> Weiss RF. Herbal Medicine. Beaconsfield, England: Beaconsfield Publishers Ltd, 1988. <br> <br> Williamson EM, ed. Major Herbs of Ayurveda. Edinburgh: Churchill Livingstone, 2002', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/milk-thistle', 'f03_web_image_URL_large' => 'milk-thistle-silybum-marianum', 'f01_header0_web_buy_script' => '', 'f03_web_store_link' => '', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/milk-thistle', 'f04_keywordsPaid' => 'Silybum marianum Milk Thistle', 'f05_significance_n' => '', 'f98_shortURL' => 'http://bit.ly/144NWAE', 'zi_sorter_un' => '', 'z_hidden_b' => '0', 'z_isFilter_b' => '0', 'z_locked_b' => '0', 'f99_hidden' => '/herbals/milk-thistle', 'zkf_oldID_t' => '2v5_00686', 'zkp_ID_t' => 'RECND352', 'zkp_recordID_cn' => '826532', 'f001_country' => '', 'f001_vendor' => '', 'f03_image1_size_cn' => '', 'f04_keywordText_t10' => '• jaundice <br> • viral hepatitis (HBV, HCV) <br> • drug-induced hepatitis <br> • non-alcoholic fatty liver disease (NAFLD) <br> • liver disease ', 'Matt_exp_webviewer' => null, 'SP_foundCount_un' => '301', 'z_log_b' => '0', 'za_created_m' => 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To add to the confusion, it has two acceptable latin binomials (Silybum marianum and Carduus marianus). Most herbalists call it <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> (Silybum marianum) because of the milky white veins that run through its green leaves. <br> <br> Although coincidentally <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> has documented <a href='/actions/galactagogue' style='text-decoration: none'>galactagogue</a> effects, its primary indication is for liver ailments. Most of the medicinal benefits focus on silymarin, which is a mixture of three flavonolignans (silibinin, silychristin, and silydianin). These polyphenols have significant <a href='/actions/antioxidant' style='text-decoration: none'>antioxidant</a> and <a href='/actions/hepatoprotective' style='text-decoration: none'>hepatoprotective</a> effects that appear to support various detox pathways in the liver and stimulate liver regeneration to protects the liver from various toxins including alcohol and drugs. Silymarin stabilizes cell membranes, stimulates protein synthesis and accelerates liver regeneration to lower liver enzymes and reduce the progression to cirrhosis. Interestingly, silymarin may help in treating amanita mushroom poisoning, which currently there's no promising antidote. However, clinical trials on the benefits of <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> on viral <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> remain inconclusive at best. <br> <br> Silymarin could be an insulin sensitizer, and clinical trials show it improves glycemic control and lipid levels in diabetic patients. Also, people with non-alcohol <a href='/conditions/fatty-liver' style='text-decoration: none'>fatty liver</a> disease (NAFLD), which <a href='/conditions/weight-loss' style='text-decoration: none'>obesity</a> and <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> are risk factors, benefit from taking <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> extracts. Because of its <a href='/actions/antioxidant' style='text-decoration: none'>antioxidant</a> effects, <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> may also aid help to prevent <a href='/conditions/cholesterol' style='text-decoration: none'>atherosclerosis</a>. <br> <br> One particularly exciting area of research is the inhibitory effect that silymarin has on multi-drug resistant (MDR) pumps that are responsible for certain types of drug resistance. Further research is needed to determine if co-administration of silymarin with some antibiotics and <a href='/actions/anticancer' style='text-decoration: none'>anticancer</a> drugs could increase their efficacy.' ], '[virtual]' => [], '[hasErrors]' => false, '[errors]' => [], '[invalid]' => [], '[repository]' => 'Record' } $settings = [ 'paypal_email' => 'accounts@ndassist.com', 'paypal_url' => 'https://www.paypal.com/cgi-bin/webscr', 'paypal_price' => '20.00', 'paypal_tax' => '2.60', 'paypal_item_name' => 'Purchase NDAssist Access', 'paypal_currency_code' => 'CAD', 'contact_form_email' => 'info@ndassist.com', 'sender_email_address' => 'website@nhpassist.com', 'student' => 'student9903', 'holistic' => 'cannp99302', 'paypal_promo_code_price' => '20.00', 'comp_feature_price' => '20.00', 'paypal_comp_feature_name' => 'Display/Hide Companies and their Products', 'paypal_purchase_name' => 'Purchase NDAssist Herbal Rx application', 'item_1' => 'ND- Assist Website Access', 'item_2' => 'Herbal 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• Tincture (1:5 in 60% EtOH): 2-5 ml tid
• Liquid extract (1:1 in 25% EtOH): 2-6 ml tid
• Decoction (seeds): 1 tsp tid
• Standardized extract (70% silymarin): 600 mg/d
Note: Leaf preparations are devoid of flavolignans, which are found in the seeds.
Generally considered safe when used as indicated.
Contra-Indications:
• gastritis & stomach ulcers
• obstructed gallbladder
Caution:
• Asteraceae allergy: contains sesquiterpene lactones
Pregnancy & Lactaction:
• Considered safe
Milk thistle may affect the drug metabolism by:
• CYP2C9 • may reduce clearance of drugs metabolized by this p450
• Glucuronidation
Milk thistle is known to interact with the following drugs:
• deferiprone
• indinavir
• raloxifene
• simeprevir
Barnes J, Anderson LA, Phillipson JD. Herbal Medicines, 3rd ed. London: Pharmaceutical Press, 2007.
Bone K. Principles and Practice of Phytotherapy. Edinburgh: Churchill Livingstone, 2000.
Bone K. A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient. St Louis, MO: Churchill Livingstone, 2003.
Brinker F. The Toxicology of Botanical Medicines, 3rd ed. Sandy, Oregon: Eclectic Medical Publications, 2000.
Felter HW, Lloyd JU. King's American Dispensatory. 1898. http://www.ibiblio.org/herbmed/eclectic/kings/main.html. Accessed: August 19, 2006.
Hoffman D. Medical Herbalism. Rochester, Vermont: Healing Arts Press, 2003.
Weiss RF. Herbal Medicine. Beaconsfield, England: Beaconsfield Publishers Ltd, 1988.
Williamson EM, ed. Major Herbs of Ayurveda. Edinburgh: Churchill Livingstone, 2002
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marianum', 'f01_header2' => 'Milk Thistle', 'f01_header3' => 'Asteraceae', 'f01_header4' => 'Carduus marianus', 'f01_header5' => 'Asteraceae', 'f01_header6' => 'Asteraceae', 'f02_body_NHP_summary' => '<a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>Milk thistle</a> goes by many names including St. Mary's thistle, blessed thistle, and cardus marianus. To add to the confusion, it has two acceptable latin binomials (Silybum marianum and Carduus marianus). Most herbalists call it <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> (Silybum marianum) because of the milky white veins that run through its green leaves. <br> <br> Although coincidentally <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> has documented <a href="https://www.nhpassist.com//actions/galactagogue" style='text-decoration: none'>galactagogue</a> effects, its primary indication is for liver ailments. Most of the medicinal benefits focus on silymarin, which is a mixture of three flavonolignans (silibinin, silychristin, and silydianin). These polyphenols have significant <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> and <a href="https://www.nhpassist.com//actions/hepatoprotective" style='text-decoration: none'>hepatoprotective</a> effects that appear to support various detox pathways in the liver and stimulate liver regeneration to protects the liver from various toxins including alcohol and drugs. Silymarin stabilizes cell membranes, stimulates protein synthesis and accelerates liver regeneration to lower liver enzymes and reduce the progression to cirrhosis. Interestingly, silymarin may help in treating amanita mushroom poisoning, which currently there's no promising antidote. However, clinical trials on the benefits of <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> on viral <a href="https://www.nhpassist.com//conditions/hepatitis" style='text-decoration: none'>hepatitis</a> remain inconclusive at best. <br> <br> Silymarin could be an insulin sensitizer, and clinical trials show it improves glycemic control and lipid levels in diabetic patients. Also, people with non-alcohol <a href="https://www.nhpassist.com//conditions/fatty-liver" style='text-decoration: none'>fatty liver</a> disease (NAFLD), which <a href="https://www.nhpassist.com//conditions/weight-loss" style='text-decoration: none'>obesity</a> and <a href="https://www.nhpassist.com//conditions/diabetes-mellitus" style='text-decoration: none'>diabetes</a> are risk factors, benefit from taking <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> extracts. Because of its <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> effects, <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> may also aid help to prevent <a href="https://www.nhpassist.com//conditions/cholesterol" style='text-decoration: none'>atherosclerosis</a>. <br> <br> One particularly exciting area of research is the inhibitory effect that silymarin has on multi-drug resistant (MDR) pumps that are responsible for certain types of drug resistance. Further research is needed to determine if co-administration of silymarin with some antibiotics and <a href="https://www.nhpassist.com//actions/anticancer" style='text-decoration: none'>anticancer</a> drugs could increase their efficacy.', 'f02_body1' => 'Hepatobiliary <br> • various liver complaints <br> • jaundice <br> • viral <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> (<a href='/conditions/hepatitis' style='text-decoration: none'>HBV</a>, <a href='/conditions/hepatitis' style='text-decoration: none'>HCV</a>) <br> • drug-induced <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> <br> • non-alcoholic <a href='/conditions/fatty-liver' style='text-decoration: none'>fatty liver</a> disease (NAFLD) <br> <br> Gastrointestinal <br> • poor appetite <br> - poor digestion <br> - <a href='/conditions/indigestion' style='text-decoration: none'>dyspepsia</a> <br> - <a href='/conditions/hypochlorhydria' style='text-decoration: none'>hypochlorhydria</a> <br> • <a href='/conditions/stomach-ulcer' style='text-decoration: none'>peptic ulcers</a> <br> • ulcerative colitis <br> <br> Cardiovascular <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>hypercholesterolemia</a> <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>atherosclerosis</a> <br> <br> Metabolic <br> • type II <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> • diabetic nephropathy <br> • <a href='/conditions/gout' style='text-decoration: none'>gout</a> <br> <br> Female reproductive <br> • <a href='/conditions/lactation' style='text-decoration: none'>agalactia</a> (poor <a href='/conditions/lactation' style='text-decoration: none'>lactation</a>) <br> <br> Cancer <br> • chemotherapy - decreases hepatotoxicity and nephrotoxicity <br> <br> Dermatologic <br> • <a href='/conditions/acne-vulgaris' style='text-decoration: none'>acne</a> <a href='/conditions/rosacea' style='text-decoration: none'>rosacea</a> <br> <br> Other <br> • <a href='/conditions/mercury-poisoning' style='text-decoration: none'>mercury poisoning</a> <br> • obsessive-compulsive disorder (<a href='/conditions/obsessive-compulsive-disorder' style='text-decoration: none'>OCD</a> )', 'f02_body2' => '• <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatic' style='text-decoration: none'>Hepatic</a> <br> • Bitter (mild) <br> • <a href='/actions/galactagogue' style='text-decoration: none'>Galactagogue</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Antiulcerogenic</a>', 'f02_body3' => '• Flavolignans (E.g. Silymarin) <br> • Phenoilc Acids <br> • Sterols (E.g. Beta-Sitosterol )', 'f02_body4' => '', 'f02_body5' => '• Tincture (1:5 in 60% EtOH): 2-5 ml tid <br> • Liquid extract (1:1 in 25% EtOH): 2-6 ml tid <br> • Decoction (seeds): 1 tsp tid <br> • Standardized extract (70% silymarin): 600 mg/d <br> <br> Note: Leaf preparations are devoid of flavolignans, which are found in the seeds.', 'f02_body6' => 'Generally considered safe when used as indicated. <br> <br> Contra-Indications: <br> • gastritis & <a href='/conditions/stomach-ulcer' style='text-decoration: none'>stomach ulcers</a> <br> • obstructed gallbladder <br> <br> Caution: <br> • Asteraceae allergy: contains sesquiterpene lactones <br> <br> <a href='/conditions/pregnancy' style='text-decoration: none'>Pregnancy</a> & Lactaction: <br> • Considered safe', 'f02_body7' => 'Milk thistle may affect the drug metabolism by: <br> • CYP2C9 • may reduce clearance of drugs metabolized by this p450 <br> • Glucuronidation <br> <br> <br> Milk thistle is known to interact with the following drugs: <br> • deferiprone <br> • indinavir <br> • raloxifene <br> • simeprevir', 'f02_body8' => 'Barnes J, Anderson LA, Phillipson JD. Herbal Medicines, 3rd ed. London: Pharmaceutical Press, 2007. <br> <br> Bone K. Principles and Practice of Phytotherapy. Edinburgh: Churchill Livingstone, 2000. <br> <br> Bone K. A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient. St Louis, MO: Churchill Livingstone, 2003. <br> <br> Brinker F. The Toxicology of Botanical Medicines, 3rd ed. Sandy, Oregon: Eclectic Medical Publications, 2000. <br> <br> Felter HW, Lloyd JU. King's American Dispensatory. 1898. http://www.ibiblio.org/herbmed/eclectic/kings/main.html. Accessed: August 19, 2006. <br> <br> Hoffman D. Medical Herbalism. Rochester, Vermont: Healing Arts Press, 2003. <br> <br> Weiss RF. Herbal Medicine. Beaconsfield, England: Beaconsfield Publishers Ltd, 1988. <br> <br> Williamson EM, ed. Major Herbs of Ayurveda. Edinburgh: Churchill Livingstone, 2002', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/milk-thistle', 'f03_web_image_URL_large' => 'milk-thistle-silybum-marianum', 'f01_header0_web_buy_script' => '', 'f03_web_store_link' => '', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/milk-thistle', 'f04_keywordsPaid' => 'Silybum marianum Milk Thistle', 'f05_significance_n' => '', 'f98_shortURL' => 'http://bit.ly/144NWAE', 'zi_sorter_un' => '', 'z_hidden_b' => '0', 'z_isFilter_b' => '0', 'z_locked_b' => '0', 'f99_hidden' => '/herbals/milk-thistle', 'zkf_oldID_t' => '2v5_00686', 'zkp_ID_t' => 'RECND352', 'zkp_recordID_cn' => '826532', 'f001_country' => '', 'f001_vendor' => '', 'f03_image1_size_cn' => '', 'f04_keywordText_t10' => '• jaundice <br> • viral hepatitis (HBV, HCV) <br> • drug-induced hepatitis <br> • non-alcoholic fatty liver disease (NAFLD) <br> • liver disease ', 'Matt_exp_webviewer' => null, 'SP_foundCount_un' => '301', 'z_log_b' => '0', 'za_created_m' => 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'[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Url' } ] $pubmed_keyword = 'Silybum marianum' $pubmed_array = [] $record = object(Cake\ORM\Entity) { 'id' => (int) 198, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Milk Thistle', 'f00_web_header2' => 'Silybum marianum', 'f00_web_title' => 'Milk Thistle (Silybum marianum) - Benefits & Side-Effects', 'f01_header1' => 'Silybum marianum', 'f01_header2' => 'Milk Thistle', 'f01_header3' => 'Asteraceae', 'f01_header4' => 'Carduus marianus', 'f01_header5' => 'Asteraceae', 'f01_header6' => 'Asteraceae', 'f02_body_NHP_summary' => '<a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>Milk thistle</a> goes by many names including St. Mary's thistle, blessed thistle, and cardus marianus. To add to the confusion, it has two acceptable latin binomials (Silybum marianum and Carduus marianus). Most herbalists call it <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> (Silybum marianum) because of the milky white veins that run through its green leaves. <br> <br> Although coincidentally <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> has documented <a href="https://www.nhpassist.com//actions/galactagogue" style='text-decoration: none'>galactagogue</a> effects, its primary indication is for liver ailments. Most of the medicinal benefits focus on silymarin, which is a mixture of three flavonolignans (silibinin, silychristin, and silydianin). These polyphenols have significant <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> and <a href="https://www.nhpassist.com//actions/hepatoprotective" style='text-decoration: none'>hepatoprotective</a> effects that appear to support various detox pathways in the liver and stimulate liver regeneration to protects the liver from various toxins including alcohol and drugs. Silymarin stabilizes cell membranes, stimulates protein synthesis and accelerates liver regeneration to lower liver enzymes and reduce the progression to cirrhosis. Interestingly, silymarin may help in treating amanita mushroom poisoning, which currently there's no promising antidote. However, clinical trials on the benefits of <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> on viral <a href="https://www.nhpassist.com//conditions/hepatitis" style='text-decoration: none'>hepatitis</a> remain inconclusive at best. <br> <br> Silymarin could be an insulin sensitizer, and clinical trials show it improves glycemic control and lipid levels in diabetic patients. Also, people with non-alcohol <a href="https://www.nhpassist.com//conditions/fatty-liver" style='text-decoration: none'>fatty liver</a> disease (NAFLD), which <a href="https://www.nhpassist.com//conditions/weight-loss" style='text-decoration: none'>obesity</a> and <a href="https://www.nhpassist.com//conditions/diabetes-mellitus" style='text-decoration: none'>diabetes</a> are risk factors, benefit from taking <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> extracts. Because of its <a href="https://www.nhpassist.com//actions/antioxidant" style='text-decoration: none'>antioxidant</a> effects, <a href="https://www.nhpassist.com//herbals/milk-thistle" style='text-decoration: none'>milk thistle</a> may also aid help to prevent <a href="https://www.nhpassist.com//conditions/cholesterol" style='text-decoration: none'>atherosclerosis</a>. <br> <br> One particularly exciting area of research is the inhibitory effect that silymarin has on multi-drug resistant (MDR) pumps that are responsible for certain types of drug resistance. Further research is needed to determine if co-administration of silymarin with some antibiotics and <a href="https://www.nhpassist.com//actions/anticancer" style='text-decoration: none'>anticancer</a> drugs could increase their efficacy.', 'f02_body1' => 'Hepatobiliary <br> • various liver complaints <br> • jaundice <br> • viral <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> (<a href='/conditions/hepatitis' style='text-decoration: none'>HBV</a>, <a href='/conditions/hepatitis' style='text-decoration: none'>HCV</a>) <br> • drug-induced <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> <br> • non-alcoholic <a href='/conditions/fatty-liver' style='text-decoration: none'>fatty liver</a> disease (NAFLD) <br> <br> Gastrointestinal <br> • poor appetite <br> - poor digestion <br> - <a href='/conditions/indigestion' style='text-decoration: none'>dyspepsia</a> <br> - <a href='/conditions/hypochlorhydria' style='text-decoration: none'>hypochlorhydria</a> <br> • <a href='/conditions/stomach-ulcer' style='text-decoration: none'>peptic ulcers</a> <br> • ulcerative colitis <br> <br> Cardiovascular <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>hypercholesterolemia</a> <br> • <a href='/conditions/cholesterol' style='text-decoration: none'>atherosclerosis</a> <br> <br> Metabolic <br> • type II <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> <br> • diabetic nephropathy <br> • <a href='/conditions/gout' style='text-decoration: none'>gout</a> <br> <br> Female reproductive <br> • <a href='/conditions/lactation' style='text-decoration: none'>agalactia</a> (poor <a href='/conditions/lactation' style='text-decoration: none'>lactation</a>) <br> <br> Cancer <br> • chemotherapy - decreases hepatotoxicity and nephrotoxicity <br> <br> Dermatologic <br> • <a href='/conditions/acne-vulgaris' style='text-decoration: none'>acne</a> <a href='/conditions/rosacea' style='text-decoration: none'>rosacea</a> <br> <br> Other <br> • <a href='/conditions/mercury-poisoning' style='text-decoration: none'>mercury poisoning</a> <br> • obsessive-compulsive disorder (<a href='/conditions/obsessive-compulsive-disorder' style='text-decoration: none'>OCD</a> )', 'f02_body2' => '• <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatic' style='text-decoration: none'>Hepatic</a> <br> • Bitter (mild) <br> • <a href='/actions/galactagogue' style='text-decoration: none'>Galactagogue</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Antiulcerogenic</a>', 'f02_body3' => '• Flavolignans (E.g. Silymarin) <br> • Phenoilc Acids <br> • Sterols (E.g. Beta-Sitosterol )', 'f02_body4' => '', 'f02_body5' => '• Tincture (1:5 in 60% EtOH): 2-5 ml tid <br> • Liquid extract (1:1 in 25% EtOH): 2-6 ml tid <br> • Decoction (seeds): 1 tsp tid <br> • Standardized extract (70% silymarin): 600 mg/d <br> <br> Note: Leaf preparations are devoid of flavolignans, which are found in the seeds.', 'f02_body6' => 'Generally considered safe when used as indicated. <br> <br> Contra-Indications: <br> • gastritis & <a href='/conditions/stomach-ulcer' style='text-decoration: none'>stomach ulcers</a> <br> • obstructed gallbladder <br> <br> Caution: <br> • Asteraceae allergy: contains sesquiterpene lactones <br> <br> <a href='/conditions/pregnancy' style='text-decoration: none'>Pregnancy</a> & Lactaction: <br> • Considered safe', 'f02_body7' => 'Milk thistle may affect the drug metabolism by: <br> • CYP2C9 • may reduce clearance of drugs metabolized by this p450 <br> • Glucuronidation <br> <br> <br> Milk thistle is known to interact with the following drugs: <br> • deferiprone <br> • indinavir <br> • raloxifene <br> • simeprevir', 'f02_body8' => 'Barnes J, Anderson LA, Phillipson JD. Herbal Medicines, 3rd ed. London: Pharmaceutical Press, 2007. <br> <br> Bone K. Principles and Practice of Phytotherapy. Edinburgh: Churchill Livingstone, 2000. <br> <br> Bone K. A Clinical Guide to Blending Liquid Herbs: Herbal Formulations for the Individual Patient. St Louis, MO: Churchill Livingstone, 2003. <br> <br> Brinker F. The Toxicology of Botanical Medicines, 3rd ed. Sandy, Oregon: Eclectic Medical Publications, 2000. <br> <br> Felter HW, Lloyd JU. King's American Dispensatory. 1898. http://www.ibiblio.org/herbmed/eclectic/kings/main.html. Accessed: August 19, 2006. <br> <br> Hoffman D. Medical Herbalism. Rochester, Vermont: Healing Arts Press, 2003. <br> <br> Weiss RF. Herbal Medicine. Beaconsfield, England: Beaconsfield Publishers Ltd, 1988. <br> <br> Williamson EM, ed. Major Herbs of Ayurveda. 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To add to the confusion, it has two acceptable latin binomials (Silybum marianum and Carduus marianus). Most herbalists call it <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> (Silybum marianum) because of the milky white veins that run through its green leaves. <br> <br> Although coincidentally <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> has documented <a href='/actions/galactagogue' style='text-decoration: none'>galactagogue</a> effects, its primary indication is for liver ailments. Most of the medicinal benefits focus on silymarin, which is a mixture of three flavonolignans (silibinin, silychristin, and silydianin). These polyphenols have significant <a href='/actions/antioxidant' style='text-decoration: none'>antioxidant</a> and <a href='/actions/hepatoprotective' style='text-decoration: none'>hepatoprotective</a> effects that appear to support various detox pathways in the liver and stimulate liver regeneration to protects the liver from various toxins including alcohol and drugs. Silymarin stabilizes cell membranes, stimulates protein synthesis and accelerates liver regeneration to lower liver enzymes and reduce the progression to cirrhosis. Interestingly, silymarin may help in treating amanita mushroom poisoning, which currently there's no promising antidote. However, clinical trials on the benefits of <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> on viral <a href='/conditions/hepatitis' style='text-decoration: none'>hepatitis</a> remain inconclusive at best. <br> <br> Silymarin could be an insulin sensitizer, and clinical trials show it improves glycemic control and lipid levels in diabetic patients. Also, people with non-alcohol <a href='/conditions/fatty-liver' style='text-decoration: none'>fatty liver</a> disease (NAFLD), which <a href='/conditions/weight-loss' style='text-decoration: none'>obesity</a> and <a href='/conditions/diabetes-mellitus' style='text-decoration: none'>diabetes</a> are risk factors, benefit from taking <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> extracts. Because of its <a href='/actions/antioxidant' style='text-decoration: none'>antioxidant</a> effects, <a href='/herbals/milk-thistle' style='text-decoration: none'>milk thistle</a> may also aid help to prevent <a href='/conditions/cholesterol' style='text-decoration: none'>atherosclerosis</a>. <br> <br> One particularly exciting area of research is the inhibitory effect that silymarin has on multi-drug resistant (MDR) pumps that are responsible for certain types of drug resistance. 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Milk Thistle
SummaryMilk thistle goes by many names including St. Mary's thistle, blessed thistle, and cardus marianus. To add to the confusion, it has two acceptable latin binomials (Silybum marianum and Carduus marianus). Most herbalists call it milk thistle (Silybum marianum) because of the milky white veins that run through its green leaves. IndicationsSign in requiredActionsSign in requiredConstituentsSign in requiredPosologySign in requiredSafetySign in requiredInteractionsSign in requiredReferencesSign in required |
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