Indications
Notice (8): Trying to access array offset on value of type null [APP/Template/Products/index.ctp, line 2752]Code Context <a name="p1"> </a><h3>Indications</h3>
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• Key factor in several biological pathways, including methylation reactions, glutathione formation and glutathione S-transferase activity
• Enteric coating protects SAMe degradation from gastric acid, allowing for significantly improved intestinal absorption
• 200 mg SAMe per tablet for flexible-dose titration
• SAMe is produced through a natural fermentation process that yields higher active ingredients over synthetic variations
• Suitable for vegetarians
Ingredients
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S-Adenosyl-L-Methionine (SAMe) : 200 mg
Microcrystalline cellulose, coating (talc, glycerin, arginine, vegetable grade magnesium stearate (lubricant), silica, sodium alginate), stearic acid, vegetable grade magnesium stearate (lubricant), magnesium hydroxide, silica, calcium oxide.
Quantity
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'f02_body2' => 'S-Adenosyl-L-Methionine (SAMe) has several critical physiological functions and is the common thread between three key metabolic pathways. Well-recognized as a unique methyl donor for more than 100 biological reactions, including DNA methylation. It also links methylation to polyamine synthesis (necessary for cell survival and growth) and transsulfuration, which is responsible for cysteine production, the rate-limiting factor in glutathione synthesis.2,3 Its unique positioning within these intersecting pathways explain its role as a regulator of redox status, cellular metabolism, proliferation, and apoptosis.4,5 Clinically proven to support a number of conditions, most notably <a href='/conditions/osteoarthritis' style='text-decoration: none'>osteoarthritis</a>, <a href='/conditions/fibromyalgia' style='text-decoration: none'>fibromyalgia</a>, neurodegenerative disease, <a href='/conditions/depression' style='text-decoration: none'>depression</a>, and liver disease.6,7 For patients with major depressive disorder, SAMe has been shown to be effective not only when compared to standard <a href='/actions/antidepressant' style='text-decoration: none'>antidepressants</a>, but also for selective serotonin reuptake inhibitor (SSRI) non-responders.8,9 It has also been shown to reduce the incidence of sexual dysfunction which commonly accompanies treatment with SSRI/SNRI therapy.10 SAMe has also shown efficacy for <a href='/conditions/osteoarthritis' style='text-decoration: none'>osteoarthritis</a> comparable to NSAIDs, including celecoxib.11,12 Quite importantly, it is likely via increases in cartilage formation, glutathione production, DNA methylation, and gene expression which contribute to its efficacy, a stark contrast from pharmaceutical <a href='/actions/analgesic' style='text-decoration: none'>analgesics</a>.13 Research also suggests benefit for neurodegenerative disease, and potentially for improving endothelial function.14-17',
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(int) 24 => 'catnip',
(int) 25 => 'selenomethionine',
(int) 26 => 'gymnema',
(int) 27 => 'upper_respiratory_tract_infections',
(int) 28 => 'opioid_addiction',
(int) 29 => 'diarrhea',
(int) 30 => 'Lactobacillus_casei',
(int) 31 => 'tonic',
(int) 32 => 'Juglans_nigra',
(int) 33 => 'Hibiscus_sabdariffa',
(int) 34 => 'conception_vessel_24',
(int) 35 => 'EGCG',
(int) 36 => 'beneficial_microflora',
(int) 37 => 'Gymnema_sylvestre',
(int) 38 => 'bloating_and_gas',
(int) 39 => 'gall_bladder_25',
(int) 40 => 'gallbladder_spasm',
(int) 41 => 'lactobacilli',
(int) 42 => 'mastodynia',
(int) 43 => 'epididymitis',
(int) 44 => 'asparagus',
(int) 45 => 'guggul',
(int) 46 => 'wounds',
(int) 47 => 'Bifidobacterium_longum_ssp._infantis',
(int) 48 => 'bronchodilator',
(int) 49 => 'achlorhydria'
]
$type = 'Products (Bioclinic Naturals)'
$brand_product = false
$title = 'Bioclinic Naturals - SAMe 200 mg'
$description = 'Bioclinic Naturals - SAMe 200 mg used for '
$category = 'Products (Bioclinic Naturals)'
$breadcumbs = [
(int) 0 => '',
(int) 1 => 'products',
(int) 2 => 'bioclinic-naturals',
(int) 3 => 'same-200-mg-9246-30-delayed-release-tablets'
]
$breadcumbs_links = [
(int) 0 => ''
]
$sender_email = ''
$subject = 'SAMe 200 mg'
$image = 'bioclinic-naturals-same-200-mg'
$image_Url = 'https://www.nhpassist.com//images/Pictures/bioclinic-naturals-same-200-mg.jpg'
$manufauturer_url = '/catalogs/view?id=products'
$imageUrl = 'https://www.nhpassist.com//images/Pictures/.jpg'
$distributedirectory = '/home/ndassist/nhpassist.com/webroot//images/Pictures/.jpg'
$_featured_products = object(Cake\ORM\Entity) {
'Record' => [
'f00_web_header1' => 'Bioclinic Naturals',
'f00_web_header2' => 'Bioclinic Naturals',
'f00_displaySub' => 'Suppliers',
'f01_header1' => 'Bioclinic Naturals',
'f01_header2' => 'Bioclinic Naturals',
'f01_header3' => '',
'f01_header4' => '',
'f01_header5' => '',
'f01_header6' => '',
'zkp_ID_t' => 'RECND636',
'zkp_recordID_cn' => '851733',
'f03_web_image_URL' => '',
'f03_imageURL_t' => '',
'f99_hidden' => '/products/bioclinic-naturals'
],
'[new]' => false,
'[accessible]' => [
'*' => true
],
'[dirty]' => [],
'[original]' => [],
'[virtual]' => [],
'[hasErrors]' => false,
'[errors]' => [],
'[invalid]' => [],
'[repository]' => 'Link'
}
$urlnew = null
$product_type = 'Products '
$similar_products_count = (int) 1
$flex_active_slide = (int) 0
$_key = (int) 0
$params = [
(int) 0 => ''
]include - APP/Template/Products/index.ctp, line 2783
Cake\View\View::_evaluate() - CORE/src/View/View.php, line 1419
Cake\View\View::_render() - CORE/src/View/View.php, line 1380
Cake\View\View::render() - CORE/src/View/View.php, line 880
Cake\Controller\Controller::render() - CORE/src/Controller/Controller.php, line 796
Cake\Http\ActionDispatcher::_invoke() - CORE/src/Http/ActionDispatcher.php, line 126
Cake\Http\ActionDispatcher::dispatch() - CORE/src/Http/ActionDispatcher.php, line 94
Cake\Http\BaseApplication::__invoke() - CORE/src/Http/BaseApplication.php, line 235
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Http\Middleware\CsrfProtectionMiddleware::__invoke() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 104
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Http\Runner::run() - CORE/src/Http/Runner.php, line 51
Cake\Routing\Middleware\RoutingMiddleware::__invoke() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 168
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Cake\Routing\Middleware\AssetMiddleware::__invoke() - CORE/src/Routing/Middleware/AssetMiddleware.php, line 88
Cake\Http\Runner::__invoke() - CORE/src/Http/Runner.php, line 65
Dose
Recommended Adult Dose: SAMe should always be taken on an empty stomach and for a minimum of 2 weeks, at which time effects should be observed.
For mood balance: 1-4 tablets 2 times per day or as directed by a health care practitioner. Consult a health care practitioner for use beyond 6 weeks.
For osteoarthritic pain: 2 tablets 3 times per day or as directed by a health care practitioner. Not to exceed 6 tablets per day. Consult a health care practitioner for use bevond 12 weeks.
