| Scientific: | Hericium erinaceus |
|---|---|
| Other: | Lion's Mane Mushroom |
| Family: | Hericiaceae |
NERVOUS
• Neurodegenerative diseases
• Alzheimer's disease
• Cognitive impairment
• Dementia
• Diabetic neuropathy
• Nerve trauma
• Depression
• Anxiety
• Memory
INFECTION
• Gasrtic ulcers - inhibit the growth of Helicobacter pylori
• Gastric cancer
CARDIOVASCULAR
• Elevated cholesterol
Other
• Fatigue
Primary:
• Neuroregenerative
• Neuroprotective
• Immunomodulating
• Anticancer
Secondary:
• Antibiotic (H. Pylori)
• Antidiabetic
• Antihyperlipidemic
• Antifatigue
• Antihypertensive
• Gastroprotective
• Cardioprotective
• Hepatoprotective
• Nephroprotective
• Vulnerary
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'24810469', (int) 17 => '24631140', (int) 18 => '24302966', (int) 19 => '24090482' ], 'record' => object(Cake\ORM\Entity) { 'id' => (int) 2860, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Lion's Mane Mushroom', 'f00_web_header2' => 'Hericium erinaceus', 'f00_web_title' => 'Hericium erinaceus - Lion's Mane Mushroom - Benefits & Side-Effects', 'f01_header1' => 'Hericium erinaceus', 'f01_header2' => 'Lion's Mane Mushroom', 'f01_header3' => 'Hericiaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => '', 'f02_body_NHP_summary' => '', 'f02_body1' => 'NERVOUS <br> • Neurodegenerative diseases <br> • <a href='/conditions/alzheimers' style='text-decoration: none'>Alzheimer's disease</a> <br> • Cognitive impairment <br> • Dementia <br> • Diabetic <a href='/conditions/nerve-pain' style='text-decoration: none'>neuropathy</a> <br> • Nerve trauma <br> • <a href='/conditions/depression' style='text-decoration: none'>Depression</a> <br> • <a href='/conditions/anxiety' style='text-decoration: none'>Anxiety</a> <br> • Memory <br> <br> INFECTION <br> • Gasrtic ulcers - inhibit the growth of Helicobacter pylori <br> • Gastric cancer <br> <br> CARDIOVASCULAR <br> • Elevated cholesterol <br> <br> Other <br> • Fatigue', 'f02_body2' => 'Primary: <br> • Neuroregenerative <br> • Neuroprotective <br> • Immunomodulating <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> <br> Secondary: <br> • Antibiotic (H. Pylori) <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • <a href='/actions/antihyperlipidemic' style='text-decoration: none'>Antihyperlipidemic</a> <br> • Antifatigue <br> • <a href='/actions/antihypertensive' style='text-decoration: none'>Antihypertensive</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Gastroprotective</a> <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/vulnerary' style='text-decoration: none'>Vulnerary</a>', 'f02_body3' => 'Terpenoids <br> • Triterpenes <br> • Diterpenoids <br> <br> Polysaccharides <br> • β -Glucan <br> • Mucilage', 'f02_body4' => 'Neurological <br> • Stimulates nerve growth factor (NGF) synthesis <br> • Increases expression of: protein kinase B (Akt) & mitogen-activated protein kinase (MAPK) signaling pathways & c-Jun and c-Fos genes <br> <br> Metabolism <br> • α -Glucosidase inhibitor <br> • HMG Co-A reductase inhibitor <br> • ACE-inhibitor', 'f02_body5' => '• Blood thinners • may have <a href='/actions/antithrombotic' style='text-decoration: none'>antiplatelet</a> effects <br> <br> Chemotherapy <br> • Doxorubicin • combination enhanced apoptosis in human hepatocellular carcinoma cells (in vitro )', 'f02_body6' => 'Generally considered safe: <br> • No toxicity seen 3g/kg body weight/day for 28 days (in vivo )', 'f02_body7' => '', 'f02_body8' => '1: Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S, <br> Suzuki Y, Watanabe S, Suga O, Sujaku T, Smogowicz AA, Truesdell SJ, Wong JW, <br> Nagahisa A, Kojima Y, Kojima N. Erinacine E as a kappa opioid receptor agonist <br> and its new analogs from a basidiomycete, Hericium ramosum. J Antibiot (Tokyo). <br> 1998 Nov;51(11):983-90. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/9918390'>PMID: 9918390</a>. <br> <br> 2: Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, <br> Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and <br> its isolated erinacine A against ischemia-injury-induced neuronal cell death via <br> the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014 Aug <br> 27;15(9):15073-89. doi: 10.3390/ijms150915073. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25167134'>PMID: 25167134</a>; PubMed <br> Central PMCID: PMC4200813. <br> <br> 3: Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M, <br> Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs <br> from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int <br> J Nanomedicine. 2015 Sep 18;10:5853-63. doi: 10.2147/IJN.S88371. eCollection <br> 2015. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26425086'>PMID: 26425086</a>; PubMed Central PMCID: PMC4583117. <br> <br> 4: Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of <br> bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep <br> 10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of <br> print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26364939'>PMID: 26364939</a>. <br> <br> 5: Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of <br> Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol <br> Macromol. 2015 Aug 24;81:656-661. doi: 10.1016/j.ijbiomac.2015.08.043. [Epub <br> ahead of print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26314904'>PMID: 26314904</a>. <br> <br> 6: Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium <br> erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive <br> Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: <br> 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26244378'>PMID: 26244378</a>. <br> <br> 7: Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H. <br> Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced <br> Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. <br> 2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960754'>PMID: 25960754</a>; PubMed Central PMCID: PMC4415746. <br> <br> 8: Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect <br> of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based <br> Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 <br> Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960751'>PMID: 25960751</a>; PubMed Central PMCID: PMC4415743. <br> <br> 9: Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L. Comparison of antioxidant and <br> antiproliferation activities of polysaccharides from eight species of medicinal <br> mushrooms. Int J Med Mushrooms. 2015;17(3):287-95. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954912'>PMID: 25954912</a>. <br> <br> 10: Liu Z, Wang Q, Cui J, Wang L, Xiong L, Wang W, Li D, Liu N, Wu Y, Mao C. <br> Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium <br> erinaceus (Higher Basidiomycetes) and Its Protective Effects on A β -Triggered <br> Neurotoxicity in PC12 Cells. Int J Med Mushrooms. 2015;17(3):219-29. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954906'>PMID: 25954906</a>. <br> <br> 11: Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides <br> extracted from Hericium erinaceus.. Exp Ther Med. 2015 Feb;9(2):483-487. Epub <br> 2014 Dec 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25574220'>PMID: 25574220</a>; PubMed Central PMCID: PMC4280918. <br> <br> 12: Zan X, Cui F, Li Y, Yang Y, Wu D, Sun W, Ping L. Hericium erinaceus <br> polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest <br> and apoptosis. Int J Biol Macromol. 2015 May;76:242-53. doi: <br> 10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25703932'>PMID: 25703932</a>. <br> <br> 13: Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H. Erinacerins C-L, <br> isoindolin-1-ones with α -glucosidase inhibitory activity from cultures of the <br> medicinal mushroom Hericium erinaceus. J Nat Prod. 2015 Jan 23;78(1):146-54. doi: <br> 10.1021/np5004388. Epub 2015 Jan 7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25565282'>PMID: 25565282</a>. <br> <br> 14: Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble <br> oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015 May;11(5):3794-9. <br> doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25529054'>PMID: 25529054</a>. <br> <br> 15: Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL <br> oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned <br> fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed <br> Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PubMed <br> <a href='http://www.ncbi.nlm.nih.gov/pubmed/24959591'>PMID: 24959591</a>; PubMed Central PMCID: PMC4052699. <br> <br> 16: Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L, <br> Wu X. Preparation, characterization, and anti-Helicobacter pylori activity of <br> Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym. 2014 Sep <br> 22;110:231-7. doi: 10.1016/j.carbpol.2014.03.081. Epub 2014 Apr 2. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24906751'>PMID: 24906751</a>. <br> <br> 17: Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the <br> toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral <br> feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi: <br> 10.1016/j.fct.2014.04.040. Epub 2014 May 6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24810469'>PMID: 24810469</a>. <br> <br> 18: Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of <br> Hericium erinaceus extracts against human gastrointestinal cancers. J <br> Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub <br> 2014 Mar 12. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24631140'>PMID: 24631140</a>. <br> <br> 19: Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, <br> Sabaratnam V. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus <br> (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer <br> in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi: <br> 10.1155/2013/492976. Epub 2013 Nov 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24302966'>PMID: 24302966</a>; PubMed Central <br> PMCID: PMC3835629. <br> <br> 20: Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic <br> activities of aqueous extract of Hericium erinaceus in experimental diabetic <br> rats. BMC Complement Altern Med. 2013 Oct 3;13:253. doi: <br> 10.1186/1472-6882-13-253. 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=> '/herbals/blue-cohosh', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 22 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Blue flag', 'f00_web_header2' => 'Iris versicolor', 'f01_header1' => 'Iris versicolor', 'f01_header2' => 'Blue flag', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/blue-flag', 'zkp_ID_t' => 'RECND249', 'zkp_recordID_cn' => '826429', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/blue-flag', 'f99_hidden' => '/herbals/blue-flag', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 23 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Bogbean', 'f00_web_header2' => 'Buckbean', 'f01_header1' => 'Menyanthes trifoliata', 'f01_header2' => 'Bogbean', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/bogbean', 'zkp_ID_t' => 'REC109add9e526752', 'zkp_recordID_cn' => '830894', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/bogbean', 'f99_hidden' => '/herbals/bogbean', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 24 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 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'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/boneset', 'f99_hidden' => '/herbals/boneset', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 26 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Buchu', 'f00_web_header2' => 'Agathosma betulina', 'f01_header1' => 'Agathosma betulina', 'f01_header2' => 'Buchu & Barosma', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/buchu-&-barosma', 'zkp_ID_t' => 'RECND251', 'zkp_recordID_cn' => '826431', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/buchu-&-barosma', 'f99_hidden' => '/herbals/buchu-barosma', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 27 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Burdock', 'f00_web_header2' => 'Arctium lappa', 'f01_header1' => 'Arctium lappa', 'f01_header2' => 'Burdock', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/burdock', 'zkp_ID_t' => 'RECND393', 'zkp_recordID_cn' => '826573', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/burdock', 'f99_hidden' => '/herbals/burdock', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 28 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Butcher's Broom', 'f00_web_header2' => 'Ruscus aculeatus', 'f01_header1' => 'Ruscus aculeatus', 'f01_header2' => 'Butcher's Broom', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/butchers-broom', 'zkp_ID_t' => 'RECMG10718', 'zkp_recordID_cn' => '828632', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/butchers-broom', 'f99_hidden' => '/herbals/butchers-broom', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 29 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Butterbur', 'f00_web_header2' => 'Petasites hybridus', 'f01_header1' => 'Petasites hybridus', 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'[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 32 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Castor oil', 'f00_web_header2' => 'Ricinus communis', 'f01_header1' => 'Ricinus communis', 'f01_header2' => 'Castor oil', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/castor-oil', 'zkp_ID_t' => 'RECND362', 'zkp_recordID_cn' => '826542', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/castor-oil', 'f99_hidden' => '/herbals/castor-oil', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 33 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Cat's Claw, Una DeGato', 'f00_web_header2' => 'Uncaria tomentosa', 'f01_header1' => 'Uncaria tomentosa / U. guainensis', 'f01_header2' => 'Cat's Claw or Una DeGato', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/cats-claw-una-degato', 'zkp_ID_t' => 'RECND254', 'zkp_recordID_cn' => '826434', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/cats-claw-una-degato', 'f99_hidden' => '/herbals/cats-claw-una-degato', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 34 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Caterpillar fungus', 'f00_web_header2' => 'Cordyceps sinensis', 'f01_header1' => 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'826433', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/catnip', 'f99_hidden' => '/herbals/catnip', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 36 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Cayenne', 'f00_web_header2' => 'Capsicum annuum', 'f01_header1' => 'Capsicum annuum', 'f01_header2' => 'Cayenne', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/cayenne', 'zkp_ID_t' => 'RECND256', 'zkp_recordID_cn' => '826436', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/cayenne', 'f99_hidden' => '/herbals/cayenne', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => 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=> object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Coffee', 'f00_web_header2' => 'Coffea arabica', 'f01_header1' => 'Coffea arabica', 'f01_header2' => 'Coffee', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/coffee', 'zkp_ID_t' => 'RECND260', 'zkp_recordID_cn' => '826440', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/coffee', 'f99_hidden' => '/herbals/coffee', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 51 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Coltsfoot', 'f00_web_header2' => 'Tussilago farfara', 'f01_header1' => 'Tussilago farfara', 'f01_header2' => 'Coltsfoot', 'f03_web_image_URL' => 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'24959591', (int) 15 => '24906751', (int) 16 => '24810469', (int) 17 => '24631140', (int) 18 => '24302966', (int) 19 => '24090482' ] $record = object(Cake\ORM\Entity) { 'id' => (int) 2860, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Lion's Mane Mushroom', 'f00_web_header2' => 'Hericium erinaceus', 'f00_web_title' => 'Hericium erinaceus - Lion's Mane Mushroom - Benefits & Side-Effects', 'f01_header1' => 'Hericium erinaceus', 'f01_header2' => 'Lion's Mane Mushroom', 'f01_header3' => 'Hericiaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => '', 'f02_body_NHP_summary' => '', 'f02_body1' => 'NERVOUS <br> • Neurodegenerative diseases <br> • <a href='/conditions/alzheimers' style='text-decoration: none'>Alzheimer's disease</a> <br> • Cognitive impairment <br> • Dementia <br> • Diabetic <a href='/conditions/nerve-pain' style='text-decoration: none'>neuropathy</a> <br> • Nerve trauma <br> • <a href='/conditions/depression' style='text-decoration: none'>Depression</a> <br> • <a href='/conditions/anxiety' style='text-decoration: none'>Anxiety</a> <br> • Memory <br> <br> INFECTION <br> • Gasrtic ulcers - inhibit the growth of Helicobacter pylori <br> • Gastric cancer <br> <br> CARDIOVASCULAR <br> • Elevated cholesterol <br> <br> Other <br> • Fatigue', 'f02_body2' => 'Primary: <br> • Neuroregenerative <br> • Neuroprotective <br> • Immunomodulating <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> <br> Secondary: <br> • Antibiotic (H. Pylori) <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • <a href='/actions/antihyperlipidemic' style='text-decoration: none'>Antihyperlipidemic</a> <br> • Antifatigue <br> • <a href='/actions/antihypertensive' style='text-decoration: none'>Antihypertensive</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Gastroprotective</a> <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/vulnerary' style='text-decoration: none'>Vulnerary</a>', 'f02_body3' => 'Terpenoids <br> • Triterpenes <br> • Diterpenoids <br> <br> Polysaccharides <br> • β -Glucan <br> • Mucilage', 'f02_body4' => 'Neurological <br> • Stimulates nerve growth factor (NGF) synthesis <br> • Increases expression of: protein kinase B (Akt) & mitogen-activated protein kinase (MAPK) signaling pathways & c-Jun and c-Fos genes <br> <br> Metabolism <br> • α -Glucosidase inhibitor <br> • HMG Co-A reductase inhibitor <br> • ACE-inhibitor', 'f02_body5' => '• Blood thinners • may have <a href='/actions/antithrombotic' style='text-decoration: none'>antiplatelet</a> effects <br> <br> Chemotherapy <br> • Doxorubicin • combination enhanced apoptosis in human hepatocellular carcinoma cells (in vitro )', 'f02_body6' => 'Generally considered safe: <br> • No toxicity seen 3g/kg body weight/day for 28 days (in vivo )', 'f02_body7' => '', 'f02_body8' => '1: Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S, <br> Suzuki Y, Watanabe S, Suga O, Sujaku T, Smogowicz AA, Truesdell SJ, Wong JW, <br> Nagahisa A, Kojima Y, Kojima N. Erinacine E as a kappa opioid receptor agonist <br> and its new analogs from a basidiomycete, Hericium ramosum. J Antibiot (Tokyo). <br> 1998 Nov;51(11):983-90. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/9918390'>PMID: 9918390</a>. <br> <br> 2: Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, <br> Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and <br> its isolated erinacine A against ischemia-injury-induced neuronal cell death via <br> the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014 Aug <br> 27;15(9):15073-89. doi: 10.3390/ijms150915073. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25167134'>PMID: 25167134</a>; PubMed <br> Central PMCID: PMC4200813. <br> <br> 3: Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M, <br> Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs <br> from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int <br> J Nanomedicine. 2015 Sep 18;10:5853-63. doi: 10.2147/IJN.S88371. eCollection <br> 2015. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26425086'>PMID: 26425086</a>; PubMed Central PMCID: PMC4583117. <br> <br> 4: Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of <br> bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep <br> 10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of <br> print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26364939'>PMID: 26364939</a>. <br> <br> 5: Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of <br> Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol <br> Macromol. 2015 Aug 24;81:656-661. doi: 10.1016/j.ijbiomac.2015.08.043. [Epub <br> ahead of print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26314904'>PMID: 26314904</a>. <br> <br> 6: Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium <br> erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive <br> Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: <br> 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26244378'>PMID: 26244378</a>. <br> <br> 7: Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H. <br> Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced <br> Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. <br> 2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960754'>PMID: 25960754</a>; PubMed Central PMCID: PMC4415746. <br> <br> 8: Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect <br> of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based <br> Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 <br> Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960751'>PMID: 25960751</a>; PubMed Central PMCID: PMC4415743. <br> <br> 9: Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L. Comparison of antioxidant and <br> antiproliferation activities of polysaccharides from eight species of medicinal <br> mushrooms. Int J Med Mushrooms. 2015;17(3):287-95. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954912'>PMID: 25954912</a>. <br> <br> 10: Liu Z, Wang Q, Cui J, Wang L, Xiong L, Wang W, Li D, Liu N, Wu Y, Mao C. <br> Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium <br> erinaceus (Higher Basidiomycetes) and Its Protective Effects on A β -Triggered <br> Neurotoxicity in PC12 Cells. Int J Med Mushrooms. 2015;17(3):219-29. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954906'>PMID: 25954906</a>. <br> <br> 11: Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides <br> extracted from Hericium erinaceus.. Exp Ther Med. 2015 Feb;9(2):483-487. Epub <br> 2014 Dec 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25574220'>PMID: 25574220</a>; PubMed Central PMCID: PMC4280918. <br> <br> 12: Zan X, Cui F, Li Y, Yang Y, Wu D, Sun W, Ping L. Hericium erinaceus <br> polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest <br> and apoptosis. Int J Biol Macromol. 2015 May;76:242-53. doi: <br> 10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25703932'>PMID: 25703932</a>. <br> <br> 13: Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H. Erinacerins C-L, <br> isoindolin-1-ones with α -glucosidase inhibitory activity from cultures of the <br> medicinal mushroom Hericium erinaceus. J Nat Prod. 2015 Jan 23;78(1):146-54. doi: <br> 10.1021/np5004388. Epub 2015 Jan 7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25565282'>PMID: 25565282</a>. <br> <br> 14: Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble <br> oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015 May;11(5):3794-9. <br> doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25529054'>PMID: 25529054</a>. <br> <br> 15: Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL <br> oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned <br> fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed <br> Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PubMed <br> <a href='http://www.ncbi.nlm.nih.gov/pubmed/24959591'>PMID: 24959591</a>; PubMed Central PMCID: PMC4052699. <br> <br> 16: Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L, <br> Wu X. Preparation, characterization, and anti-Helicobacter pylori activity of <br> Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym. 2014 Sep <br> 22;110:231-7. doi: 10.1016/j.carbpol.2014.03.081. Epub 2014 Apr 2. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24906751'>PMID: 24906751</a>. <br> <br> 17: Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the <br> toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral <br> feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi: <br> 10.1016/j.fct.2014.04.040. Epub 2014 May 6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24810469'>PMID: 24810469</a>. <br> <br> 18: Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of <br> Hericium erinaceus extracts against human gastrointestinal cancers. J <br> Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub <br> 2014 Mar 12. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24631140'>PMID: 24631140</a>. <br> <br> 19: Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, <br> Sabaratnam V. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus <br> (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer <br> in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi: <br> 10.1155/2013/492976. Epub 2013 Nov 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24302966'>PMID: 24302966</a>; PubMed Central <br> PMCID: PMC3835629. <br> <br> 20: Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic <br> activities of aqueous extract of Hericium erinaceus in experimental diabetic <br> rats. BMC Complement Altern Med. 2013 Oct 3;13:253. doi: <br> 10.1186/1472-6882-13-253. 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=> 'nephrotic_syndrome', (int) 19 => 'infectious_diarrhea', (int) 20 => 'piles', (int) 21 => 'heart_03', (int) 22 => 'hydrangea', (int) 23 => 'common_cold', (int) 24 => 'Salvia_officinalis', (int) 25 => 'respiratory_catarrh', (int) 26 => 'neuropathies', (int) 27 => 'astringent', (int) 28 => 'FMN', (int) 29 => 'qian_ceng_ta', (int) 30 => 'Jardins_La_Valheureuse', (int) 31 => 'ladys_mantle', (int) 32 => 'spleen_09', (int) 33 => 'Mahonia_aquifolium', (int) 34 => 'adrenal_insufficiency', (int) 35 => 'glutathione', (int) 36 => 'Centaurium_erythraea', (int) 37 => 'cal_mag', (int) 38 => 'libido', (int) 39 => 'red_clover', (int) 40 => 'nootropic', (int) 41 => 'OCD', (int) 42 => 'inflammation', (int) 43 => 'thyroiditis', (int) 44 => 'peppermint', (int) 45 => 'blue_flag', (int) 46 => 'five_flavor_berry', (int) 47 => 'Korean_ginseng', (int) 48 => 'increased_hair_growth', (int) 49 => 'chamomile' ] $type = 'Botanicals' $brand_product = false $title = 'Hericium erinaceus - Lion's Mane Mushroom' 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'record' => object(Cake\ORM\Entity) { 'id' => (int) 2860, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Lion's Mane Mushroom', 'f00_web_header2' => 'Hericium erinaceus', 'f00_web_title' => 'Hericium erinaceus - Lion's Mane Mushroom - Benefits & Side-Effects', 'f01_header1' => 'Hericium erinaceus', 'f01_header2' => 'Lion's Mane Mushroom', 'f01_header3' => 'Hericiaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => '', 'f02_body_NHP_summary' => '', 'f02_body1' => 'NERVOUS <br> • Neurodegenerative diseases <br> • <a href='/conditions/alzheimers' style='text-decoration: none'>Alzheimer's disease</a> <br> • Cognitive impairment <br> • Dementia <br> • Diabetic <a href='/conditions/nerve-pain' style='text-decoration: none'>neuropathy</a> <br> • Nerve trauma <br> • <a href='/conditions/depression' style='text-decoration: none'>Depression</a> <br> • <a href='/conditions/anxiety' style='text-decoration: none'>Anxiety</a> <br> • Memory <br> <br> INFECTION <br> • Gasrtic ulcers - inhibit the growth of Helicobacter pylori <br> • Gastric cancer <br> <br> CARDIOVASCULAR <br> • Elevated cholesterol <br> <br> Other <br> • Fatigue', 'f02_body2' => 'Primary: <br> • Neuroregenerative <br> • Neuroprotective <br> • Immunomodulating <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> <br> Secondary: <br> • Antibiotic (H. Pylori) <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • <a href='/actions/antihyperlipidemic' style='text-decoration: none'>Antihyperlipidemic</a> <br> • Antifatigue <br> • <a href='/actions/antihypertensive' style='text-decoration: none'>Antihypertensive</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Gastroprotective</a> <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/vulnerary' style='text-decoration: none'>Vulnerary</a>', 'f02_body3' => 'Terpenoids <br> • Triterpenes <br> • Diterpenoids <br> <br> Polysaccharides <br> • β -Glucan <br> • Mucilage', 'f02_body4' => 'Neurological <br> • Stimulates nerve growth factor (NGF) synthesis <br> • Increases expression of: protein kinase B (Akt) & mitogen-activated protein kinase (MAPK) signaling pathways & c-Jun and c-Fos genes <br> <br> Metabolism <br> • α -Glucosidase inhibitor <br> • HMG Co-A reductase inhibitor <br> • ACE-inhibitor', 'f02_body5' => '• Blood thinners • may have <a href='/actions/antithrombotic' style='text-decoration: none'>antiplatelet</a> effects <br> <br> Chemotherapy <br> • Doxorubicin • combination enhanced apoptosis in human hepatocellular carcinoma cells (in vitro )', 'f02_body6' => 'Generally considered safe: <br> • No toxicity seen 3g/kg body weight/day for 28 days (in vivo )', 'f02_body7' => '', 'f02_body8' => '1: Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S, <br> Suzuki Y, Watanabe S, Suga O, Sujaku T, Smogowicz AA, Truesdell SJ, Wong JW, <br> Nagahisa A, Kojima Y, Kojima N. Erinacine E as a kappa opioid receptor agonist <br> and its new analogs from a basidiomycete, Hericium ramosum. J Antibiot (Tokyo). <br> 1998 Nov;51(11):983-90. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/9918390'>PMID: 9918390</a>. <br> <br> 2: Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, <br> Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and <br> its isolated erinacine A against ischemia-injury-induced neuronal cell death via <br> the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014 Aug <br> 27;15(9):15073-89. doi: 10.3390/ijms150915073. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25167134'>PMID: 25167134</a>; PubMed <br> Central PMCID: PMC4200813. <br> <br> 3: Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M, <br> Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs <br> from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int <br> J Nanomedicine. 2015 Sep 18;10:5853-63. doi: 10.2147/IJN.S88371. eCollection <br> 2015. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26425086'>PMID: 26425086</a>; PubMed Central PMCID: PMC4583117. <br> <br> 4: Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of <br> bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep <br> 10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of <br> print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26364939'>PMID: 26364939</a>. <br> <br> 5: Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of <br> Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol <br> Macromol. 2015 Aug 24;81:656-661. doi: 10.1016/j.ijbiomac.2015.08.043. [Epub <br> ahead of print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26314904'>PMID: 26314904</a>. <br> <br> 6: Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium <br> erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive <br> Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: <br> 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26244378'>PMID: 26244378</a>. <br> <br> 7: Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H. <br> Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced <br> Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. <br> 2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960754'>PMID: 25960754</a>; PubMed Central PMCID: PMC4415746. <br> <br> 8: Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect <br> of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based <br> Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 <br> Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960751'>PMID: 25960751</a>; PubMed Central PMCID: PMC4415743. <br> <br> 9: Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L. Comparison of antioxidant and <br> antiproliferation activities of polysaccharides from eight species of medicinal <br> mushrooms. Int J Med Mushrooms. 2015;17(3):287-95. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954912'>PMID: 25954912</a>. <br> <br> 10: Liu Z, Wang Q, Cui J, Wang L, Xiong L, Wang W, Li D, Liu N, Wu Y, Mao C. <br> Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium <br> erinaceus (Higher Basidiomycetes) and Its Protective Effects on A β -Triggered <br> Neurotoxicity in PC12 Cells. Int J Med Mushrooms. 2015;17(3):219-29. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954906'>PMID: 25954906</a>. <br> <br> 11: Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides <br> extracted from Hericium erinaceus.. Exp Ther Med. 2015 Feb;9(2):483-487. Epub <br> 2014 Dec 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25574220'>PMID: 25574220</a>; PubMed Central PMCID: PMC4280918. <br> <br> 12: Zan X, Cui F, Li Y, Yang Y, Wu D, Sun W, Ping L. Hericium erinaceus <br> polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest <br> and apoptosis. Int J Biol Macromol. 2015 May;76:242-53. doi: <br> 10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25703932'>PMID: 25703932</a>. <br> <br> 13: Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H. Erinacerins C-L, <br> isoindolin-1-ones with α -glucosidase inhibitory activity from cultures of the <br> medicinal mushroom Hericium erinaceus. J Nat Prod. 2015 Jan 23;78(1):146-54. doi: <br> 10.1021/np5004388. Epub 2015 Jan 7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25565282'>PMID: 25565282</a>. <br> <br> 14: Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble <br> oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015 May;11(5):3794-9. <br> doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25529054'>PMID: 25529054</a>. <br> <br> 15: Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL <br> oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned <br> fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed <br> Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PubMed <br> <a href='http://www.ncbi.nlm.nih.gov/pubmed/24959591'>PMID: 24959591</a>; PubMed Central PMCID: PMC4052699. <br> <br> 16: Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L, <br> Wu X. Preparation, characterization, and anti-Helicobacter pylori activity of <br> Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym. 2014 Sep <br> 22;110:231-7. doi: 10.1016/j.carbpol.2014.03.081. Epub 2014 Apr 2. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24906751'>PMID: 24906751</a>. <br> <br> 17: Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the <br> toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral <br> feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi: <br> 10.1016/j.fct.2014.04.040. Epub 2014 May 6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24810469'>PMID: 24810469</a>. <br> <br> 18: Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of <br> Hericium erinaceus extracts against human gastrointestinal cancers. J <br> Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub <br> 2014 Mar 12. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24631140'>PMID: 24631140</a>. <br> <br> 19: Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, <br> Sabaratnam V. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus <br> (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer <br> in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi: <br> 10.1155/2013/492976. Epub 2013 Nov 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24302966'>PMID: 24302966</a>; PubMed Central <br> PMCID: PMC3835629. <br> <br> 20: Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic <br> activities of aqueous extract of Hericium erinaceus in experimental diabetic <br> rats. BMC Complement Altern Med. 2013 Oct 3;13:253. doi: <br> 10.1186/1472-6882-13-253. 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=> object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Coffee', 'f00_web_header2' => 'Coffea arabica', 'f01_header1' => 'Coffea arabica', 'f01_header2' => 'Coffee', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/coffee', 'zkp_ID_t' => 'RECND260', 'zkp_recordID_cn' => '826440', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/coffee', 'f99_hidden' => '/herbals/coffee', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 51 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Coltsfoot', 'f00_web_header2' => 'Tussilago farfara', 'f01_header1' => 'Tussilago farfara', 'f01_header2' => 'Coltsfoot', 'f03_web_image_URL' => 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false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 70 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Fenugreek', 'f00_web_header2' => 'Trigonella foenum-graceum', 'f01_header1' => 'Trigonella foenum-graceum', 'f01_header2' => 'Fenugreek', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/fenugreek', 'zkp_ID_t' => 'RECND370', 'zkp_recordID_cn' => '826550', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/fenugreek', 'f99_hidden' => '/herbals/fenugreek', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => 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'24959591', (int) 15 => '24906751', (int) 16 => '24810469', (int) 17 => '24631140', (int) 18 => '24302966', (int) 19 => '24090482' ] $record = object(Cake\ORM\Entity) { 'id' => (int) 2860, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Lion's Mane Mushroom', 'f00_web_header2' => 'Hericium erinaceus', 'f00_web_title' => 'Hericium erinaceus - Lion's Mane Mushroom - Benefits & Side-Effects', 'f01_header1' => 'Hericium erinaceus', 'f01_header2' => 'Lion's Mane Mushroom', 'f01_header3' => 'Hericiaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => '', 'f02_body_NHP_summary' => '', 'f02_body1' => 'NERVOUS <br> • Neurodegenerative diseases <br> • <a href='/conditions/alzheimers' style='text-decoration: none'>Alzheimer's disease</a> <br> • Cognitive impairment <br> • Dementia <br> • Diabetic <a href='/conditions/nerve-pain' style='text-decoration: none'>neuropathy</a> <br> • Nerve trauma <br> • <a href='/conditions/depression' style='text-decoration: none'>Depression</a> <br> • <a href='/conditions/anxiety' style='text-decoration: none'>Anxiety</a> <br> • Memory <br> <br> INFECTION <br> • Gasrtic ulcers - inhibit the growth of Helicobacter pylori <br> • Gastric cancer <br> <br> CARDIOVASCULAR <br> • Elevated cholesterol <br> <br> Other <br> • Fatigue', 'f02_body2' => 'Primary: <br> • Neuroregenerative <br> • Neuroprotective <br> • Immunomodulating <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> <br> Secondary: <br> • Antibiotic (H. Pylori) <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • <a href='/actions/antihyperlipidemic' style='text-decoration: none'>Antihyperlipidemic</a> <br> • Antifatigue <br> • <a href='/actions/antihypertensive' style='text-decoration: none'>Antihypertensive</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Gastroprotective</a> <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/vulnerary' style='text-decoration: none'>Vulnerary</a>', 'f02_body3' => 'Terpenoids <br> • Triterpenes <br> • Diterpenoids <br> <br> Polysaccharides <br> • β -Glucan <br> • Mucilage', 'f02_body4' => 'Neurological <br> • Stimulates nerve growth factor (NGF) synthesis <br> • Increases expression of: protein kinase B (Akt) & mitogen-activated protein kinase (MAPK) signaling pathways & c-Jun and c-Fos genes <br> <br> Metabolism <br> • α -Glucosidase inhibitor <br> • HMG Co-A reductase inhibitor <br> • ACE-inhibitor', 'f02_body5' => '• Blood thinners • may have <a href='/actions/antithrombotic' style='text-decoration: none'>antiplatelet</a> effects <br> <br> Chemotherapy <br> • Doxorubicin • combination enhanced apoptosis in human hepatocellular carcinoma cells (in vitro )', 'f02_body6' => 'Generally considered safe: <br> • No toxicity seen 3g/kg body weight/day for 28 days (in vivo )', 'f02_body7' => '', 'f02_body8' => '1: Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S, <br> Suzuki Y, Watanabe S, Suga O, Sujaku T, Smogowicz AA, Truesdell SJ, Wong JW, <br> Nagahisa A, Kojima Y, Kojima N. Erinacine E as a kappa opioid receptor agonist <br> and its new analogs from a basidiomycete, Hericium ramosum. J Antibiot (Tokyo). <br> 1998 Nov;51(11):983-90. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/9918390'>PMID: 9918390</a>. <br> <br> 2: Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, <br> Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and <br> its isolated erinacine A against ischemia-injury-induced neuronal cell death via <br> the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014 Aug <br> 27;15(9):15073-89. doi: 10.3390/ijms150915073. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25167134'>PMID: 25167134</a>; PubMed <br> Central PMCID: PMC4200813. <br> <br> 3: Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M, <br> Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs <br> from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int <br> J Nanomedicine. 2015 Sep 18;10:5853-63. doi: 10.2147/IJN.S88371. eCollection <br> 2015. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26425086'>PMID: 26425086</a>; PubMed Central PMCID: PMC4583117. <br> <br> 4: Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of <br> bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep <br> 10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of <br> print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26364939'>PMID: 26364939</a>. <br> <br> 5: Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of <br> Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol <br> Macromol. 2015 Aug 24;81:656-661. doi: 10.1016/j.ijbiomac.2015.08.043. [Epub <br> ahead of print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26314904'>PMID: 26314904</a>. <br> <br> 6: Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium <br> erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive <br> Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: <br> 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26244378'>PMID: 26244378</a>. <br> <br> 7: Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H. <br> Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced <br> Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. <br> 2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960754'>PMID: 25960754</a>; PubMed Central PMCID: PMC4415746. <br> <br> 8: Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect <br> of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based <br> Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 <br> Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960751'>PMID: 25960751</a>; PubMed Central PMCID: PMC4415743. <br> <br> 9: Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L. Comparison of antioxidant and <br> antiproliferation activities of polysaccharides from eight species of medicinal <br> mushrooms. Int J Med Mushrooms. 2015;17(3):287-95. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954912'>PMID: 25954912</a>. <br> <br> 10: Liu Z, Wang Q, Cui J, Wang L, Xiong L, Wang W, Li D, Liu N, Wu Y, Mao C. <br> Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium <br> erinaceus (Higher Basidiomycetes) and Its Protective Effects on A β -Triggered <br> Neurotoxicity in PC12 Cells. Int J Med Mushrooms. 2015;17(3):219-29. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954906'>PMID: 25954906</a>. <br> <br> 11: Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides <br> extracted from Hericium erinaceus.. Exp Ther Med. 2015 Feb;9(2):483-487. Epub <br> 2014 Dec 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25574220'>PMID: 25574220</a>; PubMed Central PMCID: PMC4280918. <br> <br> 12: Zan X, Cui F, Li Y, Yang Y, Wu D, Sun W, Ping L. Hericium erinaceus <br> polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest <br> and apoptosis. Int J Biol Macromol. 2015 May;76:242-53. doi: <br> 10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25703932'>PMID: 25703932</a>. <br> <br> 13: Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H. Erinacerins C-L, <br> isoindolin-1-ones with α -glucosidase inhibitory activity from cultures of the <br> medicinal mushroom Hericium erinaceus. J Nat Prod. 2015 Jan 23;78(1):146-54. doi: <br> 10.1021/np5004388. Epub 2015 Jan 7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25565282'>PMID: 25565282</a>. <br> <br> 14: Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble <br> oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015 May;11(5):3794-9. <br> doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25529054'>PMID: 25529054</a>. <br> <br> 15: Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL <br> oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned <br> fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed <br> Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PubMed <br> <a href='http://www.ncbi.nlm.nih.gov/pubmed/24959591'>PMID: 24959591</a>; PubMed Central PMCID: PMC4052699. <br> <br> 16: Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L, <br> Wu X. Preparation, characterization, and anti-Helicobacter pylori activity of <br> Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym. 2014 Sep <br> 22;110:231-7. doi: 10.1016/j.carbpol.2014.03.081. Epub 2014 Apr 2. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24906751'>PMID: 24906751</a>. <br> <br> 17: Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the <br> toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral <br> feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi: <br> 10.1016/j.fct.2014.04.040. Epub 2014 May 6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24810469'>PMID: 24810469</a>. <br> <br> 18: Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of <br> Hericium erinaceus extracts against human gastrointestinal cancers. J <br> Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub <br> 2014 Mar 12. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24631140'>PMID: 24631140</a>. <br> <br> 19: Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, <br> Sabaratnam V. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus <br> (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer <br> in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi: <br> 10.1155/2013/492976. Epub 2013 Nov 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24302966'>PMID: 24302966</a>; PubMed Central <br> PMCID: PMC3835629. <br> <br> 20: Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic <br> activities of aqueous extract of Hericium erinaceus in experimental diabetic <br> rats. BMC Complement Altern Med. 2013 Oct 3;13:253. doi: <br> 10.1186/1472-6882-13-253. 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Terpenoids
• Triterpenes
• Diterpenoids
Polysaccharides
• β -Glucan
• Mucilage
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'record' => object(Cake\ORM\Entity) { 'id' => (int) 2860, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Lion's Mane Mushroom', 'f00_web_header2' => 'Hericium erinaceus', 'f00_web_title' => 'Hericium erinaceus - Lion's Mane Mushroom - Benefits & Side-Effects', 'f01_header1' => 'Hericium erinaceus', 'f01_header2' => 'Lion's Mane Mushroom', 'f01_header3' => 'Hericiaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => '', 'f02_body_NHP_summary' => '', 'f02_body1' => 'NERVOUS <br> • Neurodegenerative diseases <br> • <a href='/conditions/alzheimers' style='text-decoration: none'>Alzheimer's disease</a> <br> • Cognitive impairment <br> • Dementia <br> • Diabetic <a href='/conditions/nerve-pain' style='text-decoration: none'>neuropathy</a> <br> • Nerve trauma <br> • <a href='/conditions/depression' style='text-decoration: none'>Depression</a> <br> • <a href='/conditions/anxiety' style='text-decoration: none'>Anxiety</a> <br> • Memory <br> <br> INFECTION <br> • Gasrtic ulcers - inhibit the growth of Helicobacter pylori <br> • Gastric cancer <br> <br> CARDIOVASCULAR <br> • Elevated cholesterol <br> <br> Other <br> • Fatigue', 'f02_body2' => 'Primary: <br> • Neuroregenerative <br> • Neuroprotective <br> • Immunomodulating <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> <br> Secondary: <br> • Antibiotic (H. Pylori) <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • <a href='/actions/antihyperlipidemic' style='text-decoration: none'>Antihyperlipidemic</a> <br> • Antifatigue <br> • <a href='/actions/antihypertensive' style='text-decoration: none'>Antihypertensive</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Gastroprotective</a> <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/vulnerary' style='text-decoration: none'>Vulnerary</a>', 'f02_body3' => 'Terpenoids <br> • Triterpenes <br> • Diterpenoids <br> <br> Polysaccharides <br> • β -Glucan <br> • Mucilage', 'f02_body4' => 'Neurological <br> • Stimulates nerve growth factor (NGF) synthesis <br> • Increases expression of: protein kinase B (Akt) & mitogen-activated protein kinase (MAPK) signaling pathways & c-Jun and c-Fos genes <br> <br> Metabolism <br> • α -Glucosidase inhibitor <br> • HMG Co-A reductase inhibitor <br> • ACE-inhibitor', 'f02_body5' => '• Blood thinners • may have <a href='/actions/antithrombotic' style='text-decoration: none'>antiplatelet</a> effects <br> <br> Chemotherapy <br> • Doxorubicin • combination enhanced apoptosis in human hepatocellular carcinoma cells (in vitro )', 'f02_body6' => 'Generally considered safe: <br> • No toxicity seen 3g/kg body weight/day for 28 days (in vivo )', 'f02_body7' => '', 'f02_body8' => '1: Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S, <br> Suzuki Y, Watanabe S, Suga O, Sujaku T, Smogowicz AA, Truesdell SJ, Wong JW, <br> Nagahisa A, Kojima Y, Kojima N. Erinacine E as a kappa opioid receptor agonist <br> and its new analogs from a basidiomycete, Hericium ramosum. J Antibiot (Tokyo). <br> 1998 Nov;51(11):983-90. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/9918390'>PMID: 9918390</a>. <br> <br> 2: Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, <br> Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and <br> its isolated erinacine A against ischemia-injury-induced neuronal cell death via <br> the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014 Aug <br> 27;15(9):15073-89. doi: 10.3390/ijms150915073. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25167134'>PMID: 25167134</a>; PubMed <br> Central PMCID: PMC4200813. <br> <br> 3: Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M, <br> Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs <br> from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int <br> J Nanomedicine. 2015 Sep 18;10:5853-63. doi: 10.2147/IJN.S88371. eCollection <br> 2015. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26425086'>PMID: 26425086</a>; PubMed Central PMCID: PMC4583117. <br> <br> 4: Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of <br> bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep <br> 10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of <br> print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26364939'>PMID: 26364939</a>. <br> <br> 5: Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of <br> Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol <br> Macromol. 2015 Aug 24;81:656-661. doi: 10.1016/j.ijbiomac.2015.08.043. [Epub <br> ahead of print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26314904'>PMID: 26314904</a>. <br> <br> 6: Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium <br> erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive <br> Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: <br> 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26244378'>PMID: 26244378</a>. <br> <br> 7: Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H. <br> Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced <br> Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. <br> 2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960754'>PMID: 25960754</a>; PubMed Central PMCID: PMC4415746. <br> <br> 8: Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect <br> of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based <br> Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 <br> Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960751'>PMID: 25960751</a>; PubMed Central PMCID: PMC4415743. <br> <br> 9: Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L. Comparison of antioxidant and <br> antiproliferation activities of polysaccharides from eight species of medicinal <br> mushrooms. Int J Med Mushrooms. 2015;17(3):287-95. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954912'>PMID: 25954912</a>. <br> <br> 10: Liu Z, Wang Q, Cui J, Wang L, Xiong L, Wang W, Li D, Liu N, Wu Y, Mao C. <br> Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium <br> erinaceus (Higher Basidiomycetes) and Its Protective Effects on A β -Triggered <br> Neurotoxicity in PC12 Cells. Int J Med Mushrooms. 2015;17(3):219-29. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954906'>PMID: 25954906</a>. <br> <br> 11: Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides <br> extracted from Hericium erinaceus.. Exp Ther Med. 2015 Feb;9(2):483-487. Epub <br> 2014 Dec 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25574220'>PMID: 25574220</a>; PubMed Central PMCID: PMC4280918. <br> <br> 12: Zan X, Cui F, Li Y, Yang Y, Wu D, Sun W, Ping L. Hericium erinaceus <br> polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest <br> and apoptosis. Int J Biol Macromol. 2015 May;76:242-53. doi: <br> 10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25703932'>PMID: 25703932</a>. <br> <br> 13: Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H. Erinacerins C-L, <br> isoindolin-1-ones with α -glucosidase inhibitory activity from cultures of the <br> medicinal mushroom Hericium erinaceus. J Nat Prod. 2015 Jan 23;78(1):146-54. doi: <br> 10.1021/np5004388. Epub 2015 Jan 7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25565282'>PMID: 25565282</a>. <br> <br> 14: Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble <br> oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015 May;11(5):3794-9. <br> doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25529054'>PMID: 25529054</a>. <br> <br> 15: Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL <br> oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned <br> fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed <br> Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PubMed <br> <a href='http://www.ncbi.nlm.nih.gov/pubmed/24959591'>PMID: 24959591</a>; PubMed Central PMCID: PMC4052699. <br> <br> 16: Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L, <br> Wu X. Preparation, characterization, and anti-Helicobacter pylori activity of <br> Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym. 2014 Sep <br> 22;110:231-7. doi: 10.1016/j.carbpol.2014.03.081. Epub 2014 Apr 2. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24906751'>PMID: 24906751</a>. <br> <br> 17: Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the <br> toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral <br> feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi: <br> 10.1016/j.fct.2014.04.040. Epub 2014 May 6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24810469'>PMID: 24810469</a>. <br> <br> 18: Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of <br> Hericium erinaceus extracts against human gastrointestinal cancers. J <br> Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub <br> 2014 Mar 12. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24631140'>PMID: 24631140</a>. <br> <br> 19: Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, <br> Sabaratnam V. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus <br> (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer <br> in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi: <br> 10.1155/2013/492976. Epub 2013 Nov 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24302966'>PMID: 24302966</a>; PubMed Central <br> PMCID: PMC3835629. <br> <br> 20: Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic <br> activities of aqueous extract of Hericium erinaceus in experimental diabetic <br> rats. BMC Complement Altern Med. 2013 Oct 3;13:253. doi: <br> 10.1186/1472-6882-13-253. 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{ 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Cat's Claw, Una DeGato', 'f00_web_header2' => 'Uncaria tomentosa', 'f01_header1' => 'Uncaria tomentosa / U. guainensis', 'f01_header2' => 'Cat's Claw or Una DeGato', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/cats-claw-una-degato', 'zkp_ID_t' => 'RECND254', 'zkp_recordID_cn' => '826434', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/cats-claw-una-degato', 'f99_hidden' => '/herbals/cats-claw-una-degato', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 34 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Caterpillar fungus', 'f00_web_header2' => 'Cordyceps sinensis', 'f01_header1' => 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'826433', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/catnip', 'f99_hidden' => '/herbals/catnip', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 36 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Cayenne', 'f00_web_header2' => 'Capsicum annuum', 'f01_header1' => 'Capsicum annuum', 'f01_header2' => 'Cayenne', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/cayenne', 'zkp_ID_t' => 'RECND256', 'zkp_recordID_cn' => '826436', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/cayenne', 'f99_hidden' => '/herbals/cayenne', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => 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reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 42 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Cherry bark (wild )', 'f00_web_header2' => 'Prunus serotina', 'f01_header1' => 'Prunus serotina', 'f01_header2' => 'Wild black cherry, Choke Cherry', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wild-black-cherry-choke-cherry', 'zkp_ID_t' => 'RECND322', 'zkp_recordID_cn' => '826502', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wild-black-cherry-choke-cherry', 'f99_hidden' => '/herbals/wild-black-cherry-choke-cherry', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth 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=> object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Coffee', 'f00_web_header2' => 'Coffea arabica', 'f01_header1' => 'Coffea arabica', 'f01_header2' => 'Coffee', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/coffee', 'zkp_ID_t' => 'RECND260', 'zkp_recordID_cn' => '826440', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/coffee', 'f99_hidden' => '/herbals/coffee', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 51 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Coltsfoot', 'f00_web_header2' => 'Tussilago farfara', 'f01_header1' => 'Tussilago farfara', 'f01_header2' => 'Coltsfoot', 'f03_web_image_URL' => 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<br> • <a href='/conditions/anxiety' style='text-decoration: none'>Anxiety</a> <br> • Memory <br> <br> INFECTION <br> • Gasrtic ulcers - inhibit the growth of Helicobacter pylori <br> • Gastric cancer <br> <br> CARDIOVASCULAR <br> • Elevated cholesterol <br> <br> Other <br> • Fatigue', 'f02_body2' => 'Primary: <br> • Neuroregenerative <br> • Neuroprotective <br> • Immunomodulating <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> <br> Secondary: <br> • Antibiotic (H. Pylori) <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • <a href='/actions/antihyperlipidemic' style='text-decoration: none'>Antihyperlipidemic</a> <br> • Antifatigue <br> • <a href='/actions/antihypertensive' style='text-decoration: none'>Antihypertensive</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Gastroprotective</a> <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/vulnerary' style='text-decoration: none'>Vulnerary</a>', 'f02_body3' => 'Terpenoids <br> • Triterpenes <br> • Diterpenoids <br> <br> Polysaccharides <br> • β -Glucan <br> • Mucilage', 'f02_body4' => 'Neurological <br> • Stimulates nerve growth factor (NGF) synthesis <br> • Increases expression of: protein kinase B (Akt) & mitogen-activated protein kinase (MAPK) signaling pathways & c-Jun and c-Fos genes <br> <br> Metabolism <br> • α -Glucosidase inhibitor <br> • HMG Co-A reductase inhibitor <br> • ACE-inhibitor', 'f02_body5' => '• Blood thinners • may have <a href='/actions/antithrombotic' style='text-decoration: none'>antiplatelet</a> effects <br> <br> Chemotherapy <br> • Doxorubicin • combination enhanced apoptosis in human hepatocellular carcinoma cells (in vitro )', 'f02_body6' => 'Generally considered safe: <br> • No toxicity seen 3g/kg body weight/day for 28 days (in vivo )', 'f02_body7' => '', 'f02_body8' => '1: Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S, <br> Suzuki Y, Watanabe S, Suga O, Sujaku T, Smogowicz AA, Truesdell SJ, Wong JW, <br> Nagahisa A, Kojima Y, Kojima N. Erinacine E as a kappa opioid receptor agonist <br> and its new analogs from a basidiomycete, Hericium ramosum. J Antibiot (Tokyo). <br> 1998 Nov;51(11):983-90. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/9918390'>PMID: 9918390</a>. <br> <br> 2: Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, <br> Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and <br> its isolated erinacine A against ischemia-injury-induced neuronal cell death via <br> the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014 Aug <br> 27;15(9):15073-89. doi: 10.3390/ijms150915073. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25167134'>PMID: 25167134</a>; PubMed <br> Central PMCID: PMC4200813. <br> <br> 3: Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M, <br> Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs <br> from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int <br> J Nanomedicine. 2015 Sep 18;10:5853-63. doi: 10.2147/IJN.S88371. eCollection <br> 2015. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26425086'>PMID: 26425086</a>; PubMed Central PMCID: PMC4583117. <br> <br> 4: Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of <br> bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep <br> 10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of <br> print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26364939'>PMID: 26364939</a>. <br> <br> 5: Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of <br> Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol <br> Macromol. 2015 Aug 24;81:656-661. doi: 10.1016/j.ijbiomac.2015.08.043. [Epub <br> ahead of print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26314904'>PMID: 26314904</a>. <br> <br> 6: Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium <br> erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive <br> Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: <br> 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26244378'>PMID: 26244378</a>. <br> <br> 7: Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H. <br> Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced <br> Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. <br> 2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960754'>PMID: 25960754</a>; PubMed Central PMCID: PMC4415746. <br> <br> 8: Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect <br> of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based <br> Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 <br> Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960751'>PMID: 25960751</a>; PubMed Central PMCID: PMC4415743. <br> <br> 9: Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L. Comparison of antioxidant and <br> antiproliferation activities of polysaccharides from eight species of medicinal <br> mushrooms. Int J Med Mushrooms. 2015;17(3):287-95. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954912'>PMID: 25954912</a>. <br> <br> 10: Liu Z, Wang Q, Cui J, Wang L, Xiong L, Wang W, Li D, Liu N, Wu Y, Mao C. <br> Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium <br> erinaceus (Higher Basidiomycetes) and Its Protective Effects on A β -Triggered <br> Neurotoxicity in PC12 Cells. Int J Med Mushrooms. 2015;17(3):219-29. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954906'>PMID: 25954906</a>. <br> <br> 11: Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides <br> extracted from Hericium erinaceus.. Exp Ther Med. 2015 Feb;9(2):483-487. Epub <br> 2014 Dec 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25574220'>PMID: 25574220</a>; PubMed Central PMCID: PMC4280918. <br> <br> 12: Zan X, Cui F, Li Y, Yang Y, Wu D, Sun W, Ping L. Hericium erinaceus <br> polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest <br> and apoptosis. Int J Biol Macromol. 2015 May;76:242-53. doi: <br> 10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25703932'>PMID: 25703932</a>. <br> <br> 13: Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H. Erinacerins C-L, <br> isoindolin-1-ones with α -glucosidase inhibitory activity from cultures of the <br> medicinal mushroom Hericium erinaceus. J Nat Prod. 2015 Jan 23;78(1):146-54. doi: <br> 10.1021/np5004388. Epub 2015 Jan 7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25565282'>PMID: 25565282</a>. <br> <br> 14: Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble <br> oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015 May;11(5):3794-9. <br> doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25529054'>PMID: 25529054</a>. <br> <br> 15: Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL <br> oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned <br> fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed <br> Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PubMed <br> <a href='http://www.ncbi.nlm.nih.gov/pubmed/24959591'>PMID: 24959591</a>; PubMed Central PMCID: PMC4052699. <br> <br> 16: Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L, <br> Wu X. Preparation, characterization, and anti-Helicobacter pylori activity of <br> Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym. 2014 Sep <br> 22;110:231-7. doi: 10.1016/j.carbpol.2014.03.081. Epub 2014 Apr 2. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24906751'>PMID: 24906751</a>. <br> <br> 17: Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the <br> toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral <br> feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi: <br> 10.1016/j.fct.2014.04.040. Epub 2014 May 6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24810469'>PMID: 24810469</a>. <br> <br> 18: Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of <br> Hericium erinaceus extracts against human gastrointestinal cancers. J <br> Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub <br> 2014 Mar 12. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24631140'>PMID: 24631140</a>. <br> <br> 19: Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, <br> Sabaratnam V. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus <br> (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer <br> in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi: <br> 10.1155/2013/492976. Epub 2013 Nov 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24302966'>PMID: 24302966</a>; PubMed Central <br> PMCID: PMC3835629. <br> <br> 20: Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic <br> activities of aqueous extract of Hericium erinaceus in experimental diabetic <br> rats. BMC Complement Altern Med. 2013 Oct 3;13:253. doi: <br> 10.1186/1472-6882-13-253. 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=> 'nephrotic_syndrome', (int) 19 => 'infectious_diarrhea', (int) 20 => 'piles', (int) 21 => 'heart_03', (int) 22 => 'hydrangea', (int) 23 => 'common_cold', (int) 24 => 'Salvia_officinalis', (int) 25 => 'respiratory_catarrh', (int) 26 => 'neuropathies', (int) 27 => 'astringent', (int) 28 => 'FMN', (int) 29 => 'qian_ceng_ta', (int) 30 => 'Jardins_La_Valheureuse', (int) 31 => 'ladys_mantle', (int) 32 => 'spleen_09', (int) 33 => 'Mahonia_aquifolium', (int) 34 => 'adrenal_insufficiency', (int) 35 => 'glutathione', (int) 36 => 'Centaurium_erythraea', (int) 37 => 'cal_mag', (int) 38 => 'libido', (int) 39 => 'red_clover', (int) 40 => 'nootropic', (int) 41 => 'OCD', (int) 42 => 'inflammation', (int) 43 => 'thyroiditis', (int) 44 => 'peppermint', (int) 45 => 'blue_flag', (int) 46 => 'five_flavor_berry', (int) 47 => 'Korean_ginseng', (int) 48 => 'increased_hair_growth', (int) 49 => 'chamomile' ] $type = 'Botanicals' $brand_product = false $title = 'Hericium erinaceus - Lion's Mane Mushroom' $description = 'Lion's Mane Mushroom - Hericium erinaceus used for chronic fatigue syndrome, cancer, stomach ulcer, Alzheimers disease, anxiety, cognitive support, depression, ' $category = 'Botanicals' $breadcumbs = [ (int) 0 => '', (int) 1 => 'herbals', (int) 2 => 'lions-mane-mushroom' ] $breadcumbs_links = [ (int) 0 => '', (int) 1 => 'herbals', (int) 2 => 'lions-mane-mushroom' ] $_pubmed_id = '24090482' $sender_email = '' $subject = 'Lion's Mane Mushroom' $image = 'lions-mane-mushroom-hericium-erinaceus' $image_Url = 'https://www.nhpassist.com//images/Pictures/lions-mane-mushroom-hericium-erinaceus.jpg'include - APP/Template/Products/index.ctp, line 905 Cake\View\View::_evaluate() - CORE/src/View/View.php, line 1419 Cake\View\View::_render() - CORE/src/View/View.php, line 1380 Cake\View\View::render() - CORE/src/View/View.php, line 880 Cake\Controller\Controller::render() - CORE/src/Controller/Controller.php, line 796 Cake\Http\ActionDispatcher::_invoke() - 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Neurological
• Stimulates nerve growth factor (NGF) synthesis
• Increases expression of: protein kinase B (Akt) & mitogen-activated protein kinase (MAPK) signaling pathways & c-Jun and c-Fos genes
Metabolism
• α -Glucosidase inhibitor
• HMG Co-A reductase inhibitor
• ACE-inhibitor
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'24810469', (int) 17 => '24631140', (int) 18 => '24302966', (int) 19 => '24090482' ], 'record' => object(Cake\ORM\Entity) { 'id' => (int) 2860, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Lion's Mane Mushroom', 'f00_web_header2' => 'Hericium erinaceus', 'f00_web_title' => 'Hericium erinaceus - Lion's Mane Mushroom - Benefits & Side-Effects', 'f01_header1' => 'Hericium erinaceus', 'f01_header2' => 'Lion's Mane Mushroom', 'f01_header3' => 'Hericiaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => '', 'f02_body_NHP_summary' => '', 'f02_body1' => 'NERVOUS <br> • Neurodegenerative diseases <br> • <a href='/conditions/alzheimers' style='text-decoration: none'>Alzheimer's disease</a> <br> • Cognitive impairment <br> • Dementia <br> • Diabetic <a href='/conditions/nerve-pain' style='text-decoration: none'>neuropathy</a> <br> • Nerve trauma <br> • <a href='/conditions/depression' style='text-decoration: none'>Depression</a> <br> • <a href='/conditions/anxiety' style='text-decoration: none'>Anxiety</a> <br> • Memory <br> <br> INFECTION <br> • Gasrtic ulcers - inhibit the growth of Helicobacter pylori <br> • Gastric cancer <br> <br> CARDIOVASCULAR <br> • Elevated cholesterol <br> <br> Other <br> • Fatigue', 'f02_body2' => 'Primary: <br> • Neuroregenerative <br> • Neuroprotective <br> • Immunomodulating <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> <br> Secondary: <br> • Antibiotic (H. Pylori) <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • <a href='/actions/antihyperlipidemic' style='text-decoration: none'>Antihyperlipidemic</a> <br> • Antifatigue <br> • <a href='/actions/antihypertensive' style='text-decoration: none'>Antihypertensive</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Gastroprotective</a> <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/vulnerary' style='text-decoration: none'>Vulnerary</a>', 'f02_body3' => 'Terpenoids <br> • Triterpenes <br> • Diterpenoids <br> <br> Polysaccharides <br> • β -Glucan <br> • Mucilage', 'f02_body4' => 'Neurological <br> • Stimulates nerve growth factor (NGF) synthesis <br> • Increases expression of: protein kinase B (Akt) & mitogen-activated protein kinase (MAPK) signaling pathways & c-Jun and c-Fos genes <br> <br> Metabolism <br> • α -Glucosidase inhibitor <br> • HMG Co-A reductase inhibitor <br> • ACE-inhibitor', 'f02_body5' => '• Blood thinners • may have <a href='/actions/antithrombotic' style='text-decoration: none'>antiplatelet</a> effects <br> <br> Chemotherapy <br> • Doxorubicin • combination enhanced apoptosis in human hepatocellular carcinoma cells (in vitro )', 'f02_body6' => 'Generally considered safe: <br> • No toxicity seen 3g/kg body weight/day for 28 days (in vivo )', 'f02_body7' => '', 'f02_body8' => '1: Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S, <br> Suzuki Y, Watanabe S, Suga O, Sujaku T, Smogowicz AA, Truesdell SJ, Wong JW, <br> Nagahisa A, Kojima Y, Kojima N. Erinacine E as a kappa opioid receptor agonist <br> and its new analogs from a basidiomycete, Hericium ramosum. J Antibiot (Tokyo). <br> 1998 Nov;51(11):983-90. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/9918390'>PMID: 9918390</a>. <br> <br> 2: Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, <br> Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and <br> its isolated erinacine A against ischemia-injury-induced neuronal cell death via <br> the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014 Aug <br> 27;15(9):15073-89. doi: 10.3390/ijms150915073. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25167134'>PMID: 25167134</a>; PubMed <br> Central PMCID: PMC4200813. <br> <br> 3: Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M, <br> Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs <br> from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int <br> J Nanomedicine. 2015 Sep 18;10:5853-63. doi: 10.2147/IJN.S88371. eCollection <br> 2015. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26425086'>PMID: 26425086</a>; PubMed Central PMCID: PMC4583117. <br> <br> 4: Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of <br> bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep <br> 10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of <br> print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26364939'>PMID: 26364939</a>. <br> <br> 5: Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of <br> Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol <br> Macromol. 2015 Aug 24;81:656-661. doi: 10.1016/j.ijbiomac.2015.08.043. [Epub <br> ahead of print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26314904'>PMID: 26314904</a>. <br> <br> 6: Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium <br> erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive <br> Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: <br> 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26244378'>PMID: 26244378</a>. <br> <br> 7: Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H. <br> Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced <br> Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. <br> 2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960754'>PMID: 25960754</a>; PubMed Central PMCID: PMC4415746. <br> <br> 8: Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect <br> of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based <br> Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 <br> Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960751'>PMID: 25960751</a>; PubMed Central PMCID: PMC4415743. <br> <br> 9: Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L. Comparison of antioxidant and <br> antiproliferation activities of polysaccharides from eight species of medicinal <br> mushrooms. Int J Med Mushrooms. 2015;17(3):287-95. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954912'>PMID: 25954912</a>. <br> <br> 10: Liu Z, Wang Q, Cui J, Wang L, Xiong L, Wang W, Li D, Liu N, Wu Y, Mao C. <br> Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium <br> erinaceus (Higher Basidiomycetes) and Its Protective Effects on A β -Triggered <br> Neurotoxicity in PC12 Cells. Int J Med Mushrooms. 2015;17(3):219-29. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954906'>PMID: 25954906</a>. <br> <br> 11: Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides <br> extracted from Hericium erinaceus.. Exp Ther Med. 2015 Feb;9(2):483-487. Epub <br> 2014 Dec 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25574220'>PMID: 25574220</a>; PubMed Central PMCID: PMC4280918. <br> <br> 12: Zan X, Cui F, Li Y, Yang Y, Wu D, Sun W, Ping L. Hericium erinaceus <br> polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest <br> and apoptosis. Int J Biol Macromol. 2015 May;76:242-53. doi: <br> 10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25703932'>PMID: 25703932</a>. <br> <br> 13: Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H. Erinacerins C-L, <br> isoindolin-1-ones with α -glucosidase inhibitory activity from cultures of the <br> medicinal mushroom Hericium erinaceus. J Nat Prod. 2015 Jan 23;78(1):146-54. doi: <br> 10.1021/np5004388. Epub 2015 Jan 7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25565282'>PMID: 25565282</a>. <br> <br> 14: Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble <br> oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015 May;11(5):3794-9. <br> doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25529054'>PMID: 25529054</a>. <br> <br> 15: Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL <br> oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned <br> fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed <br> Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PubMed <br> <a href='http://www.ncbi.nlm.nih.gov/pubmed/24959591'>PMID: 24959591</a>; PubMed Central PMCID: PMC4052699. <br> <br> 16: Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L, <br> Wu X. Preparation, characterization, and anti-Helicobacter pylori activity of <br> Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym. 2014 Sep <br> 22;110:231-7. doi: 10.1016/j.carbpol.2014.03.081. Epub 2014 Apr 2. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24906751'>PMID: 24906751</a>. <br> <br> 17: Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the <br> toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral <br> feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi: <br> 10.1016/j.fct.2014.04.040. Epub 2014 May 6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24810469'>PMID: 24810469</a>. <br> <br> 18: Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of <br> Hericium erinaceus extracts against human gastrointestinal cancers. J <br> Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub <br> 2014 Mar 12. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24631140'>PMID: 24631140</a>. <br> <br> 19: Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, <br> Sabaratnam V. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus <br> (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer <br> in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi: <br> 10.1155/2013/492976. Epub 2013 Nov 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24302966'>PMID: 24302966</a>; PubMed Central <br> PMCID: PMC3835629. <br> <br> 20: Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic <br> activities of aqueous extract of Hericium erinaceus in experimental diabetic <br> rats. BMC Complement Altern Med. 2013 Oct 3;13:253. doi: <br> 10.1186/1472-6882-13-253. 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'[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 23 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Bogbean', 'f00_web_header2' => 'Buckbean', 'f01_header1' => 'Menyanthes trifoliata', 'f01_header2' => 'Bogbean', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/bogbean', 'zkp_ID_t' => 'REC109add9e526752', 'zkp_recordID_cn' => '830894', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/bogbean', 'f99_hidden' => '/herbals/bogbean', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 24 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 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'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/boneset', 'f99_hidden' => '/herbals/boneset', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 26 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Buchu', 'f00_web_header2' => 'Agathosma betulina', 'f01_header1' => 'Agathosma betulina', 'f01_header2' => 'Buchu & Barosma', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/buchu-&-barosma', 'zkp_ID_t' => 'RECND251', 'zkp_recordID_cn' => '826431', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/buchu-&-barosma', 'f99_hidden' => '/herbals/buchu-barosma', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth 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=> object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Coffee', 'f00_web_header2' => 'Coffea arabica', 'f01_header1' => 'Coffea arabica', 'f01_header2' => 'Coffee', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/coffee', 'zkp_ID_t' => 'RECND260', 'zkp_recordID_cn' => '826440', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/coffee', 'f99_hidden' => '/herbals/coffee', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 51 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Coltsfoot', 'f00_web_header2' => 'Tussilago farfara', 'f01_header1' => 'Tussilago farfara', 'f01_header2' => 'Coltsfoot', 'f03_web_image_URL' => 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{ 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Jamaican Dogwood', 'f00_web_header2' => 'Piscidia erythrina', 'f01_header1' => 'Piscidia erythrina', 'f01_header2' => 'Jamaican Dogwood', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/jamaican-dogwood', 'zkp_ID_t' => 'RECND290', 'zkp_recordID_cn' => '826470', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/jamaican-dogwood', 'f99_hidden' => '/herbals/jamaican-dogwood', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 99 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Juniper', 'f00_web_header2' => 'Juniperus communis', 'f01_header1' => 'Juniperus communis', 'f01_header2' => 'Juniper', 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'[repository]' => 'Record' }, (int) 128 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Peppermint', 'f00_web_header2' => 'Mentha piperita', 'f01_header1' => 'Mentha piperita', 'f01_header2' => 'Peppermint; Mint', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/peppermint;-mint', 'zkp_ID_t' => 'RECND368', 'zkp_recordID_cn' => '826548', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/peppermint;-mint', 'f99_hidden' => '/herbals/peppermint', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 129 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Pipsissewa', 'f00_web_header2' => 'Chimaphila umbellate', 'f01_header1' 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<br> • <a href='/conditions/anxiety' style='text-decoration: none'>Anxiety</a> <br> • Memory <br> <br> INFECTION <br> • Gasrtic ulcers - inhibit the growth of Helicobacter pylori <br> • Gastric cancer <br> <br> CARDIOVASCULAR <br> • Elevated cholesterol <br> <br> Other <br> • Fatigue', 'f02_body2' => 'Primary: <br> • Neuroregenerative <br> • Neuroprotective <br> • Immunomodulating <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> <br> Secondary: <br> • Antibiotic (H. Pylori) <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • <a href='/actions/antihyperlipidemic' style='text-decoration: none'>Antihyperlipidemic</a> <br> • Antifatigue <br> • <a href='/actions/antihypertensive' style='text-decoration: none'>Antihypertensive</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Gastroprotective</a> <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/vulnerary' style='text-decoration: none'>Vulnerary</a>', 'f02_body3' => 'Terpenoids <br> • Triterpenes <br> • Diterpenoids <br> <br> Polysaccharides <br> • β -Glucan <br> • Mucilage', 'f02_body4' => 'Neurological <br> • Stimulates nerve growth factor (NGF) synthesis <br> • Increases expression of: protein kinase B (Akt) & mitogen-activated protein kinase (MAPK) signaling pathways & c-Jun and c-Fos genes <br> <br> Metabolism <br> • α -Glucosidase inhibitor <br> • HMG Co-A reductase inhibitor <br> • ACE-inhibitor', 'f02_body5' => '• Blood thinners • may have <a href='/actions/antithrombotic' style='text-decoration: none'>antiplatelet</a> effects <br> <br> Chemotherapy <br> • Doxorubicin • combination enhanced apoptosis in human hepatocellular carcinoma cells (in vitro )', 'f02_body6' => 'Generally considered safe: <br> • No toxicity seen 3g/kg body weight/day for 28 days (in vivo )', 'f02_body7' => '', 'f02_body8' => '1: Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S, <br> Suzuki Y, Watanabe S, Suga O, Sujaku T, Smogowicz AA, Truesdell SJ, Wong JW, <br> Nagahisa A, Kojima Y, Kojima N. Erinacine E as a kappa opioid receptor agonist <br> and its new analogs from a basidiomycete, Hericium ramosum. J Antibiot (Tokyo). <br> 1998 Nov;51(11):983-90. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/9918390'>PMID: 9918390</a>. <br> <br> 2: Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, <br> Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and <br> its isolated erinacine A against ischemia-injury-induced neuronal cell death via <br> the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014 Aug <br> 27;15(9):15073-89. doi: 10.3390/ijms150915073. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25167134'>PMID: 25167134</a>; PubMed <br> Central PMCID: PMC4200813. <br> <br> 3: Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M, <br> Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs <br> from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int <br> J Nanomedicine. 2015 Sep 18;10:5853-63. doi: 10.2147/IJN.S88371. eCollection <br> 2015. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26425086'>PMID: 26425086</a>; PubMed Central PMCID: PMC4583117. <br> <br> 4: Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of <br> bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep <br> 10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of <br> print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26364939'>PMID: 26364939</a>. <br> <br> 5: Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of <br> Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol <br> Macromol. 2015 Aug 24;81:656-661. doi: 10.1016/j.ijbiomac.2015.08.043. [Epub <br> ahead of print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26314904'>PMID: 26314904</a>. <br> <br> 6: Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium <br> erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive <br> Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: <br> 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26244378'>PMID: 26244378</a>. <br> <br> 7: Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H. <br> Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced <br> Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. <br> 2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960754'>PMID: 25960754</a>; PubMed Central PMCID: PMC4415746. <br> <br> 8: Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect <br> of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based <br> Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 <br> Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960751'>PMID: 25960751</a>; PubMed Central PMCID: PMC4415743. <br> <br> 9: Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L. Comparison of antioxidant and <br> antiproliferation activities of polysaccharides from eight species of medicinal <br> mushrooms. Int J Med Mushrooms. 2015;17(3):287-95. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954912'>PMID: 25954912</a>. <br> <br> 10: Liu Z, Wang Q, Cui J, Wang L, Xiong L, Wang W, Li D, Liu N, Wu Y, Mao C. <br> Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium <br> erinaceus (Higher Basidiomycetes) and Its Protective Effects on A β -Triggered <br> Neurotoxicity in PC12 Cells. Int J Med Mushrooms. 2015;17(3):219-29. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954906'>PMID: 25954906</a>. <br> <br> 11: Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides <br> extracted from Hericium erinaceus.. Exp Ther Med. 2015 Feb;9(2):483-487. Epub <br> 2014 Dec 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25574220'>PMID: 25574220</a>; PubMed Central PMCID: PMC4280918. <br> <br> 12: Zan X, Cui F, Li Y, Yang Y, Wu D, Sun W, Ping L. Hericium erinaceus <br> polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest <br> and apoptosis. Int J Biol Macromol. 2015 May;76:242-53. doi: <br> 10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25703932'>PMID: 25703932</a>. <br> <br> 13: Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H. Erinacerins C-L, <br> isoindolin-1-ones with α -glucosidase inhibitory activity from cultures of the <br> medicinal mushroom Hericium erinaceus. J Nat Prod. 2015 Jan 23;78(1):146-54. doi: <br> 10.1021/np5004388. Epub 2015 Jan 7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25565282'>PMID: 25565282</a>. <br> <br> 14: Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble <br> oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015 May;11(5):3794-9. <br> doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25529054'>PMID: 25529054</a>. <br> <br> 15: Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL <br> oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned <br> fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed <br> Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PubMed <br> <a href='http://www.ncbi.nlm.nih.gov/pubmed/24959591'>PMID: 24959591</a>; PubMed Central PMCID: PMC4052699. <br> <br> 16: Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L, <br> Wu X. Preparation, characterization, and anti-Helicobacter pylori activity of <br> Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym. 2014 Sep <br> 22;110:231-7. doi: 10.1016/j.carbpol.2014.03.081. Epub 2014 Apr 2. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24906751'>PMID: 24906751</a>. <br> <br> 17: Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the <br> toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral <br> feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi: <br> 10.1016/j.fct.2014.04.040. Epub 2014 May 6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24810469'>PMID: 24810469</a>. <br> <br> 18: Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of <br> Hericium erinaceus extracts against human gastrointestinal cancers. J <br> Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub <br> 2014 Mar 12. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24631140'>PMID: 24631140</a>. <br> <br> 19: Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, <br> Sabaratnam V. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus <br> (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer <br> in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi: <br> 10.1155/2013/492976. Epub 2013 Nov 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24302966'>PMID: 24302966</a>; PubMed Central <br> PMCID: PMC3835629. <br> <br> 20: Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic <br> activities of aqueous extract of Hericium erinaceus in experimental diabetic <br> rats. BMC Complement Altern Med. 2013 Oct 3;13:253. doi: <br> 10.1186/1472-6882-13-253. 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ulcers - inhibit the growth of Helicobacter pylori <br> • Gastric cancer <br> <br> CARDIOVASCULAR <br> • Elevated cholesterol <br> <br> Other <br> • Fatigue', 'f02_body2' => 'Primary: <br> • Neuroregenerative <br> • Neuroprotective <br> • Immunomodulating <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> <br> Secondary: <br> • Antibiotic (H. Pylori) <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • <a href='/actions/antihyperlipidemic' style='text-decoration: none'>Antihyperlipidemic</a> <br> • Antifatigue <br> • <a href='/actions/antihypertensive' style='text-decoration: none'>Antihypertensive</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Gastroprotective</a> <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/vulnerary' style='text-decoration: none'>Vulnerary</a>', 'f02_body3' => 'Terpenoids <br> • Triterpenes <br> • Diterpenoids <br> <br> Polysaccharides <br> • β -Glucan <br> • Mucilage', 'f02_body4' => 'Neurological <br> • Stimulates nerve growth factor (NGF) synthesis <br> • Increases expression of: protein kinase B (Akt) & mitogen-activated protein kinase (MAPK) signaling pathways & c-Jun and c-Fos genes <br> <br> Metabolism <br> • α -Glucosidase inhibitor <br> • HMG Co-A reductase inhibitor <br> • ACE-inhibitor', 'f02_body5' => '• Blood thinners • may have <a href='/actions/antithrombotic' style='text-decoration: none'>antiplatelet</a> effects <br> <br> Chemotherapy <br> • Doxorubicin • combination enhanced apoptosis in human hepatocellular carcinoma cells (in vitro )', 'f02_body6' => 'Generally considered safe: <br> • No toxicity seen 3g/kg body weight/day for 28 days (in vivo )', 'f02_body7' => '', 'f02_body8' => '1: Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S, <br> Suzuki Y, Watanabe S, Suga O, Sujaku T, Smogowicz AA, Truesdell SJ, Wong JW, <br> Nagahisa A, Kojima Y, Kojima N. Erinacine E as a kappa opioid receptor agonist <br> and its new analogs from a basidiomycete, Hericium ramosum. J Antibiot (Tokyo). <br> 1998 Nov;51(11):983-90. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/9918390'>PMID: 9918390</a>. <br> <br> 2: Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, <br> Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and <br> its isolated erinacine A against ischemia-injury-induced neuronal cell death via <br> the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014 Aug <br> 27;15(9):15073-89. doi: 10.3390/ijms150915073. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25167134'>PMID: 25167134</a>; PubMed <br> Central PMCID: PMC4200813. <br> <br> 3: Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M, <br> Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs <br> from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int <br> J Nanomedicine. 2015 Sep 18;10:5853-63. doi: 10.2147/IJN.S88371. eCollection <br> 2015. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26425086'>PMID: 26425086</a>; PubMed Central PMCID: PMC4583117. <br> <br> 4: Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of <br> bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep <br> 10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of <br> print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26364939'>PMID: 26364939</a>. <br> <br> 5: Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of <br> Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol <br> Macromol. 2015 Aug 24;81:656-661. doi: 10.1016/j.ijbiomac.2015.08.043. [Epub <br> ahead of print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26314904'>PMID: 26314904</a>. <br> <br> 6: Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium <br> erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive <br> Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: <br> 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26244378'>PMID: 26244378</a>. <br> <br> 7: Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H. <br> Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced <br> Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. <br> 2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960754'>PMID: 25960754</a>; PubMed Central PMCID: PMC4415746. <br> <br> 8: Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect <br> of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based <br> Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 <br> Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960751'>PMID: 25960751</a>; PubMed Central PMCID: PMC4415743. <br> <br> 9: Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L. Comparison of antioxidant and <br> antiproliferation activities of polysaccharides from eight species of medicinal <br> mushrooms. Int J Med Mushrooms. 2015;17(3):287-95. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954912'>PMID: 25954912</a>. <br> <br> 10: Liu Z, Wang Q, Cui J, Wang L, Xiong L, Wang W, Li D, Liu N, Wu Y, Mao C. <br> Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium <br> erinaceus (Higher Basidiomycetes) and Its Protective Effects on A β -Triggered <br> Neurotoxicity in PC12 Cells. Int J Med Mushrooms. 2015;17(3):219-29. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954906'>PMID: 25954906</a>. <br> <br> 11: Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides <br> extracted from Hericium erinaceus.. Exp Ther Med. 2015 Feb;9(2):483-487. Epub <br> 2014 Dec 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25574220'>PMID: 25574220</a>; PubMed Central PMCID: PMC4280918. <br> <br> 12: Zan X, Cui F, Li Y, Yang Y, Wu D, Sun W, Ping L. Hericium erinaceus <br> polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest <br> and apoptosis. Int J Biol Macromol. 2015 May;76:242-53. doi: <br> 10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25703932'>PMID: 25703932</a>. <br> <br> 13: Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H. Erinacerins C-L, <br> isoindolin-1-ones with α -glucosidase inhibitory activity from cultures of the <br> medicinal mushroom Hericium erinaceus. J Nat Prod. 2015 Jan 23;78(1):146-54. doi: <br> 10.1021/np5004388. Epub 2015 Jan 7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25565282'>PMID: 25565282</a>. <br> <br> 14: Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble <br> oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015 May;11(5):3794-9. <br> doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25529054'>PMID: 25529054</a>. <br> <br> 15: Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL <br> oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned <br> fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed <br> Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PubMed <br> <a href='http://www.ncbi.nlm.nih.gov/pubmed/24959591'>PMID: 24959591</a>; PubMed Central PMCID: PMC4052699. <br> <br> 16: Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L, <br> Wu X. Preparation, characterization, and anti-Helicobacter pylori activity of <br> Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym. 2014 Sep <br> 22;110:231-7. doi: 10.1016/j.carbpol.2014.03.081. Epub 2014 Apr 2. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24906751'>PMID: 24906751</a>. <br> <br> 17: Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the <br> toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral <br> feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi: <br> 10.1016/j.fct.2014.04.040. Epub 2014 May 6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24810469'>PMID: 24810469</a>. <br> <br> 18: Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of <br> Hericium erinaceus extracts against human gastrointestinal cancers. J <br> Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub <br> 2014 Mar 12. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24631140'>PMID: 24631140</a>. <br> <br> 19: Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, <br> Sabaratnam V. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus <br> (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer <br> in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi: <br> 10.1155/2013/492976. Epub 2013 Nov 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24302966'>PMID: 24302966</a>; PubMed Central <br> PMCID: PMC3835629. <br> <br> 20: Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic <br> activities of aqueous extract of Hericium erinaceus in experimental diabetic <br> rats. BMC Complement Altern Med. 2013 Oct 3;13:253. doi: <br> 10.1186/1472-6882-13-253. 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{ 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Cat's Claw, Una DeGato', 'f00_web_header2' => 'Uncaria tomentosa', 'f01_header1' => 'Uncaria tomentosa / U. guainensis', 'f01_header2' => 'Cat's Claw or Una DeGato', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/cats-claw-una-degato', 'zkp_ID_t' => 'RECND254', 'zkp_recordID_cn' => '826434', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/cats-claw-una-degato', 'f99_hidden' => '/herbals/cats-claw-una-degato', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 34 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Caterpillar fungus', 'f00_web_header2' => 'Cordyceps sinensis', 'f01_header1' => 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reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 42 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Cherry bark (wild )', 'f00_web_header2' => 'Prunus serotina', 'f01_header1' => 'Prunus serotina', 'f01_header2' => 'Wild black cherry, Choke Cherry', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/wild-black-cherry-choke-cherry', 'zkp_ID_t' => 'RECND322', 'zkp_recordID_cn' => '826502', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/wild-black-cherry-choke-cherry', 'f99_hidden' => '/herbals/wild-black-cherry-choke-cherry', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth 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'https://www.nhpassist.com/herbals/herbals/yellow-dock', 'zkp_ID_t' => 'RECND363', 'zkp_recordID_cn' => '826543', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/yellow-dock', 'f99_hidden' => '/herbals/yellow-dock', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' } ] $clipboard = false $keyword_products = [] $url_id = [] $pubmed_keyword = 'Hericium erinaceus' $pubmed_array = [ (int) 0 => '9918390', (int) 1 => '25167134', (int) 2 => '26425086', (int) 3 => '26364939', (int) 4 => '26314904', (int) 5 => '26244378', (int) 6 => '25960754', (int) 7 => '25960751', (int) 8 => '25954912', (int) 9 => '25954906', (int) 10 => '25574220', (int) 11 => '25703932', (int) 12 => '25565282', (int) 13 => '25529054', (int) 14 => '24959591', (int) 15 => '24906751', (int) 16 => '24810469', (int) 17 => '24631140', (int) 18 => '24302966', (int) 19 => '24090482' ] $record = object(Cake\ORM\Entity) { 'id' => (int) 2860, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Lion's Mane Mushroom', 'f00_web_header2' => 'Hericium erinaceus', 'f00_web_title' => 'Hericium erinaceus - Lion's Mane Mushroom - Benefits & Side-Effects', 'f01_header1' => 'Hericium erinaceus', 'f01_header2' => 'Lion's Mane Mushroom', 'f01_header3' => 'Hericiaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => '', 'f02_body_NHP_summary' => '', 'f02_body1' => 'NERVOUS <br> • Neurodegenerative diseases <br> • <a href='/conditions/alzheimers' style='text-decoration: none'>Alzheimer's disease</a> <br> • Cognitive impairment <br> • Dementia <br> • Diabetic <a href='/conditions/nerve-pain' style='text-decoration: none'>neuropathy</a> <br> • Nerve trauma <br> • <a href='/conditions/depression' style='text-decoration: none'>Depression</a> <br> • <a href='/conditions/anxiety' style='text-decoration: none'>Anxiety</a> <br> • Memory <br> <br> INFECTION <br> • Gasrtic ulcers - inhibit the growth of Helicobacter pylori <br> • Gastric cancer <br> <br> CARDIOVASCULAR <br> • Elevated cholesterol <br> <br> Other <br> • Fatigue', 'f02_body2' => 'Primary: <br> • Neuroregenerative <br> • Neuroprotective <br> • Immunomodulating <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> <br> Secondary: <br> • Antibiotic (H. Pylori) <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • <a href='/actions/antihyperlipidemic' style='text-decoration: none'>Antihyperlipidemic</a> <br> • Antifatigue <br> • <a href='/actions/antihypertensive' style='text-decoration: none'>Antihypertensive</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Gastroprotective</a> <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/vulnerary' style='text-decoration: none'>Vulnerary</a>', 'f02_body3' => 'Terpenoids <br> • Triterpenes <br> • Diterpenoids <br> <br> Polysaccharides <br> • β -Glucan <br> • Mucilage', 'f02_body4' => 'Neurological <br> • Stimulates nerve growth factor (NGF) synthesis <br> • Increases expression of: protein kinase B (Akt) & mitogen-activated protein kinase (MAPK) signaling pathways & c-Jun and c-Fos genes <br> <br> Metabolism <br> • α -Glucosidase inhibitor <br> • HMG Co-A reductase inhibitor <br> • ACE-inhibitor', 'f02_body5' => '• Blood thinners • may have <a href='/actions/antithrombotic' style='text-decoration: none'>antiplatelet</a> effects <br> <br> Chemotherapy <br> • Doxorubicin • combination enhanced apoptosis in human hepatocellular carcinoma cells (in vitro )', 'f02_body6' => 'Generally considered safe: <br> • No toxicity seen 3g/kg body weight/day for 28 days (in vivo )', 'f02_body7' => '', 'f02_body8' => '1: Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S, <br> Suzuki Y, Watanabe S, Suga O, Sujaku T, Smogowicz AA, Truesdell SJ, Wong JW, <br> Nagahisa A, Kojima Y, Kojima N. Erinacine E as a kappa opioid receptor agonist <br> and its new analogs from a basidiomycete, Hericium ramosum. J Antibiot (Tokyo). <br> 1998 Nov;51(11):983-90. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/9918390'>PMID: 9918390</a>. <br> <br> 2: Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, <br> Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and <br> its isolated erinacine A against ischemia-injury-induced neuronal cell death via <br> the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014 Aug <br> 27;15(9):15073-89. doi: 10.3390/ijms150915073. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25167134'>PMID: 25167134</a>; PubMed <br> Central PMCID: PMC4200813. <br> <br> 3: Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M, <br> Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs <br> from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int <br> J Nanomedicine. 2015 Sep 18;10:5853-63. doi: 10.2147/IJN.S88371. eCollection <br> 2015. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26425086'>PMID: 26425086</a>; PubMed Central PMCID: PMC4583117. <br> <br> 4: Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of <br> bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep <br> 10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of <br> print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26364939'>PMID: 26364939</a>. <br> <br> 5: Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of <br> Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol <br> Macromol. 2015 Aug 24;81:656-661. doi: 10.1016/j.ijbiomac.2015.08.043. [Epub <br> ahead of print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26314904'>PMID: 26314904</a>. <br> <br> 6: Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium <br> erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive <br> Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: <br> 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26244378'>PMID: 26244378</a>. <br> <br> 7: Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H. <br> Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced <br> Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. <br> 2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960754'>PMID: 25960754</a>; PubMed Central PMCID: PMC4415746. <br> <br> 8: Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect <br> of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based <br> Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 <br> Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960751'>PMID: 25960751</a>; PubMed Central PMCID: PMC4415743. <br> <br> 9: Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L. Comparison of antioxidant and <br> antiproliferation activities of polysaccharides from eight species of medicinal <br> mushrooms. Int J Med Mushrooms. 2015;17(3):287-95. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954912'>PMID: 25954912</a>. <br> <br> 10: Liu Z, Wang Q, Cui J, Wang L, Xiong L, Wang W, Li D, Liu N, Wu Y, Mao C. <br> Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium <br> erinaceus (Higher Basidiomycetes) and Its Protective Effects on A β -Triggered <br> Neurotoxicity in PC12 Cells. Int J Med Mushrooms. 2015;17(3):219-29. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954906'>PMID: 25954906</a>. <br> <br> 11: Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides <br> extracted from Hericium erinaceus.. Exp Ther Med. 2015 Feb;9(2):483-487. Epub <br> 2014 Dec 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25574220'>PMID: 25574220</a>; PubMed Central PMCID: PMC4280918. <br> <br> 12: Zan X, Cui F, Li Y, Yang Y, Wu D, Sun W, Ping L. Hericium erinaceus <br> polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest <br> and apoptosis. Int J Biol Macromol. 2015 May;76:242-53. doi: <br> 10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25703932'>PMID: 25703932</a>. <br> <br> 13: Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H. Erinacerins C-L, <br> isoindolin-1-ones with α -glucosidase inhibitory activity from cultures of the <br> medicinal mushroom Hericium erinaceus. J Nat Prod. 2015 Jan 23;78(1):146-54. doi: <br> 10.1021/np5004388. Epub 2015 Jan 7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25565282'>PMID: 25565282</a>. <br> <br> 14: Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble <br> oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015 May;11(5):3794-9. <br> doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25529054'>PMID: 25529054</a>. <br> <br> 15: Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL <br> oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned <br> fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed <br> Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PubMed <br> <a href='http://www.ncbi.nlm.nih.gov/pubmed/24959591'>PMID: 24959591</a>; PubMed Central PMCID: PMC4052699. <br> <br> 16: Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L, <br> Wu X. Preparation, characterization, and anti-Helicobacter pylori activity of <br> Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym. 2014 Sep <br> 22;110:231-7. doi: 10.1016/j.carbpol.2014.03.081. Epub 2014 Apr 2. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24906751'>PMID: 24906751</a>. <br> <br> 17: Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the <br> toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral <br> feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi: <br> 10.1016/j.fct.2014.04.040. Epub 2014 May 6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24810469'>PMID: 24810469</a>. <br> <br> 18: Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of <br> Hericium erinaceus extracts against human gastrointestinal cancers. J <br> Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub <br> 2014 Mar 12. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24631140'>PMID: 24631140</a>. <br> <br> 19: Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, <br> Sabaratnam V. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus <br> (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer <br> in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi: <br> 10.1155/2013/492976. Epub 2013 Nov 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24302966'>PMID: 24302966</a>; PubMed Central <br> PMCID: PMC3835629. <br> <br> 20: Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic <br> activities of aqueous extract of Hericium erinaceus in experimental diabetic <br> rats. BMC Complement Altern Med. 2013 Oct 3;13:253. doi: <br> 10.1186/1472-6882-13-253. 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$description = 'Lion's Mane Mushroom - Hericium erinaceus used for chronic fatigue syndrome, cancer, stomach ulcer, Alzheimers disease, anxiety, cognitive support, depression, ' $category = 'Botanicals' $breadcumbs = [ (int) 0 => '', (int) 1 => 'herbals', (int) 2 => 'lions-mane-mushroom' ] $breadcumbs_links = [ (int) 0 => '', (int) 1 => 'herbals', (int) 2 => 'lions-mane-mushroom' ] $_pubmed_id = '24090482' $sender_email = '' $subject = 'Lion's Mane Mushroom' $image = 'lions-mane-mushroom-hericium-erinaceus' $image_Url = 'https://www.nhpassist.com//images/Pictures/lions-mane-mushroom-hericium-erinaceus.jpg'include - APP/Template/Products/index.ctp, line 912 Cake\View\View::_evaluate() - CORE/src/View/View.php, line 1419 Cake\View\View::_render() - CORE/src/View/View.php, line 1380 Cake\View\View::render() - CORE/src/View/View.php, line 880 Cake\Controller\Controller::render() - CORE/src/Controller/Controller.php, line 796 Cake\Http\ActionDispatcher::_invoke() - 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• Blood thinners • may have antiplatelet effects
Chemotherapy
• Doxorubicin • combination enhanced apoptosis in human hepatocellular carcinoma cells (in vitro )
Generally considered safe:
• No toxicity seen 3g/kg body weight/day for 28 days (in vivo )
1: Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S,
Suzuki Y, Watanabe S, Suga O, Sujaku T, Smogowicz AA, Truesdell SJ, Wong JW,
Nagahisa A, Kojima Y, Kojima N. Erinacine E as a kappa opioid receptor agonist
and its new analogs from a basidiomycete, Hericium ramosum. J Antibiot (Tokyo).
1998 Nov;51(11):983-90. PubMed PMID: 9918390.
2: Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP,
Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and
its isolated erinacine A against ischemia-injury-induced neuronal cell death via
the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014 Aug
27;15(9):15073-89. doi: 10.3390/ijms150915073. PubMed PMID: 25167134; PubMed
Central PMCID: PMC4200813.
3: Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M,
Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs
from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int
J Nanomedicine. 2015 Sep 18;10:5853-63. doi: 10.2147/IJN.S88371. eCollection
2015. PubMed PMID: 26425086; PubMed Central PMCID: PMC4583117.
4: Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of
bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep
10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of
print] PubMed PMID: 26364939.
5: Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of
Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol
Macromol. 2015 Aug 24;81:656-661. doi: 10.1016/j.ijbiomac.2015.08.043. [Epub
ahead of print] PubMed PMID: 26314904.
6: Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium
erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive
Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi:
10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PubMed PMID: 26244378.
7: Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H.
Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced
Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med.
2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16. PubMed PMID: 25960754; PubMed Central PMCID: PMC4415746.
8: Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect
of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based
Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015
Apr 16. PubMed PMID: 25960751; PubMed Central PMCID: PMC4415743.
9: Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L. Comparison of antioxidant and
antiproliferation activities of polysaccharides from eight species of medicinal
mushrooms. Int J Med Mushrooms. 2015;17(3):287-95. PubMed PMID: 25954912.
10: Liu Z, Wang Q, Cui J, Wang L, Xiong L, Wang W, Li D, Liu N, Wu Y, Mao C.
Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium
erinaceus (Higher Basidiomycetes) and Its Protective Effects on A β -Triggered
Neurotoxicity in PC12 Cells. Int J Med Mushrooms. 2015;17(3):219-29. PubMed PMID: 25954906.
11: Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides
extracted from Hericium erinaceus.. Exp Ther Med. 2015 Feb;9(2):483-487. Epub
2014 Dec 16. PubMed PMID: 25574220; PubMed Central PMCID: PMC4280918.
12: Zan X, Cui F, Li Y, Yang Y, Wu D, Sun W, Ping L. Hericium erinaceus
polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest
and apoptosis. Int J Biol Macromol. 2015 May;76:242-53. doi:
10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20. PubMed PMID: 25703932.
13: Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H. Erinacerins C-L,
isoindolin-1-ones with α -glucosidase inhibitory activity from cultures of the
medicinal mushroom Hericium erinaceus. J Nat Prod. 2015 Jan 23;78(1):146-54. doi:
10.1021/np5004388. Epub 2015 Jan 7. PubMed PMID: 25565282.
14: Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble
oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015 May;11(5):3794-9.
doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. PubMed PMID: 25529054.
15: Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL
oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned
fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed
Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PubMed
PMID: 24959591; PubMed Central PMCID: PMC4052699.
16: Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L,
Wu X. Preparation, characterization, and anti-Helicobacter pylori activity of
Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym. 2014 Sep
22;110:231-7. doi: 10.1016/j.carbpol.2014.03.081. Epub 2014 Apr 2. PubMed PMID: 24906751.
17: Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the
toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral
feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi:
10.1016/j.fct.2014.04.040. Epub 2014 May 6. PubMed PMID: 24810469.
18: Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of
Hericium erinaceus extracts against human gastrointestinal cancers. J
Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub
2014 Mar 12. PubMed PMID: 24631140.
19: Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S,
Sabaratnam V. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus
(Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer
in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi:
10.1155/2013/492976. Epub 2013 Nov 5. PubMed PMID: 24302966; PubMed Central
PMCID: PMC3835629.
20: Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic
activities of aqueous extract of Hericium erinaceus in experimental diabetic
rats. BMC Complement Altern Med. 2013 Oct 3;13:253. doi:
10.1186/1472-6882-13-253. PubMed PMID: 24090482; PubMed Central PMCID:
PMC3852124.
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'24302966', (int) 19 => '24090482' ], 'record' => object(Cake\ORM\Entity) { 'id' => (int) 2860, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Lion's Mane Mushroom', 'f00_web_header2' => 'Hericium erinaceus', 'f00_web_title' => 'Hericium erinaceus - Lion's Mane Mushroom - Benefits & Side-Effects', 'f01_header1' => 'Hericium erinaceus', 'f01_header2' => 'Lion's Mane Mushroom', 'f01_header3' => 'Hericiaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => '', 'f02_body_NHP_summary' => '', 'f02_body1' => 'NERVOUS <br> • Neurodegenerative diseases <br> • <a href='/conditions/alzheimers' style='text-decoration: none'>Alzheimer's disease</a> <br> • Cognitive impairment <br> • Dementia <br> • Diabetic <a href='/conditions/nerve-pain' style='text-decoration: none'>neuropathy</a> <br> • Nerve trauma <br> • <a href='/conditions/depression' style='text-decoration: none'>Depression</a> <br> • <a href='/conditions/anxiety' style='text-decoration: none'>Anxiety</a> <br> • Memory <br> <br> INFECTION <br> • Gasrtic ulcers - inhibit the growth of Helicobacter pylori <br> • Gastric cancer <br> <br> CARDIOVASCULAR <br> • Elevated cholesterol <br> <br> Other <br> • Fatigue', 'f02_body2' => 'Primary: <br> • Neuroregenerative <br> • Neuroprotective <br> • Immunomodulating <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> <br> Secondary: <br> • Antibiotic (H. Pylori) <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • <a href='/actions/antihyperlipidemic' style='text-decoration: none'>Antihyperlipidemic</a> <br> • Antifatigue <br> • <a href='/actions/antihypertensive' style='text-decoration: none'>Antihypertensive</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Gastroprotective</a> <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/vulnerary' style='text-decoration: none'>Vulnerary</a>', 'f02_body3' => 'Terpenoids <br> • Triterpenes <br> • Diterpenoids <br> <br> Polysaccharides <br> • β -Glucan <br> • Mucilage', 'f02_body4' => 'Neurological <br> • Stimulates nerve growth factor (NGF) synthesis <br> • Increases expression of: protein kinase B (Akt) & mitogen-activated protein kinase (MAPK) signaling pathways & c-Jun and c-Fos genes <br> <br> Metabolism <br> • α -Glucosidase inhibitor <br> • HMG Co-A reductase inhibitor <br> • ACE-inhibitor', 'f02_body5' => '• Blood thinners • may have <a href='/actions/antithrombotic' style='text-decoration: none'>antiplatelet</a> effects <br> <br> Chemotherapy <br> • Doxorubicin • combination enhanced apoptosis in human hepatocellular carcinoma cells (in vitro )', 'f02_body6' => 'Generally considered safe: <br> • No toxicity seen 3g/kg body weight/day for 28 days (in vivo )', 'f02_body7' => '', 'f02_body8' => '1: Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S, <br> Suzuki Y, Watanabe S, Suga O, Sujaku T, Smogowicz AA, Truesdell SJ, Wong JW, <br> Nagahisa A, Kojima Y, Kojima N. Erinacine E as a kappa opioid receptor agonist <br> and its new analogs from a basidiomycete, Hericium ramosum. J Antibiot (Tokyo). <br> 1998 Nov;51(11):983-90. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/9918390'>PMID: 9918390</a>. <br> <br> 2: Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, <br> Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and <br> its isolated erinacine A against ischemia-injury-induced neuronal cell death via <br> the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014 Aug <br> 27;15(9):15073-89. doi: 10.3390/ijms150915073. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25167134'>PMID: 25167134</a>; PubMed <br> Central PMCID: PMC4200813. <br> <br> 3: Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M, <br> Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs <br> from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int <br> J Nanomedicine. 2015 Sep 18;10:5853-63. doi: 10.2147/IJN.S88371. eCollection <br> 2015. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26425086'>PMID: 26425086</a>; PubMed Central PMCID: PMC4583117. <br> <br> 4: Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of <br> bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep <br> 10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of <br> print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26364939'>PMID: 26364939</a>. <br> <br> 5: Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of <br> Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol <br> Macromol. 2015 Aug 24;81:656-661. doi: 10.1016/j.ijbiomac.2015.08.043. [Epub <br> ahead of print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26314904'>PMID: 26314904</a>. <br> <br> 6: Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium <br> erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive <br> Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: <br> 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26244378'>PMID: 26244378</a>. <br> <br> 7: Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H. <br> Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced <br> Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. <br> 2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960754'>PMID: 25960754</a>; PubMed Central PMCID: PMC4415746. <br> <br> 8: Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect <br> of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based <br> Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 <br> Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960751'>PMID: 25960751</a>; PubMed Central PMCID: PMC4415743. <br> <br> 9: Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L. Comparison of antioxidant and <br> antiproliferation activities of polysaccharides from eight species of medicinal <br> mushrooms. Int J Med Mushrooms. 2015;17(3):287-95. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954912'>PMID: 25954912</a>. <br> <br> 10: Liu Z, Wang Q, Cui J, Wang L, Xiong L, Wang W, Li D, Liu N, Wu Y, Mao C. <br> Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium <br> erinaceus (Higher Basidiomycetes) and Its Protective Effects on A β -Triggered <br> Neurotoxicity in PC12 Cells. Int J Med Mushrooms. 2015;17(3):219-29. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954906'>PMID: 25954906</a>. <br> <br> 11: Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides <br> extracted from Hericium erinaceus.. Exp Ther Med. 2015 Feb;9(2):483-487. Epub <br> 2014 Dec 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25574220'>PMID: 25574220</a>; PubMed Central PMCID: PMC4280918. <br> <br> 12: Zan X, Cui F, Li Y, Yang Y, Wu D, Sun W, Ping L. Hericium erinaceus <br> polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest <br> and apoptosis. Int J Biol Macromol. 2015 May;76:242-53. doi: <br> 10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25703932'>PMID: 25703932</a>. <br> <br> 13: Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H. Erinacerins C-L, <br> isoindolin-1-ones with α -glucosidase inhibitory activity from cultures of the <br> medicinal mushroom Hericium erinaceus. J Nat Prod. 2015 Jan 23;78(1):146-54. doi: <br> 10.1021/np5004388. Epub 2015 Jan 7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25565282'>PMID: 25565282</a>. <br> <br> 14: Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble <br> oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015 May;11(5):3794-9. <br> doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25529054'>PMID: 25529054</a>. <br> <br> 15: Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL <br> oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned <br> fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed <br> Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PubMed <br> <a href='http://www.ncbi.nlm.nih.gov/pubmed/24959591'>PMID: 24959591</a>; PubMed Central PMCID: PMC4052699. <br> <br> 16: Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L, <br> Wu X. Preparation, characterization, and anti-Helicobacter pylori activity of <br> Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym. 2014 Sep <br> 22;110:231-7. doi: 10.1016/j.carbpol.2014.03.081. Epub 2014 Apr 2. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24906751'>PMID: 24906751</a>. <br> <br> 17: Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the <br> toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral <br> feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi: <br> 10.1016/j.fct.2014.04.040. Epub 2014 May 6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24810469'>PMID: 24810469</a>. <br> <br> 18: Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of <br> Hericium erinaceus extracts against human gastrointestinal cancers. J <br> Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub <br> 2014 Mar 12. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24631140'>PMID: 24631140</a>. <br> <br> 19: Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, <br> Sabaratnam V. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus <br> (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer <br> in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi: <br> 10.1155/2013/492976. Epub 2013 Nov 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24302966'>PMID: 24302966</a>; PubMed Central <br> PMCID: PMC3835629. <br> <br> 20: Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic <br> activities of aqueous extract of Hericium erinaceus in experimental diabetic <br> rats. BMC Complement Altern Med. 2013 Oct 3;13:253. doi: <br> 10.1186/1472-6882-13-253. 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reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 43 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Chicory', 'f00_web_header2' => 'Cichorium intybus', 'f01_header1' => 'Cichorium intybus', 'f01_header2' => 'Chicory', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/chicory', 'zkp_ID_t' => 'RECND347', 'zkp_recordID_cn' => '826527', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/chicory', 'f99_hidden' => '/herbals/chicory', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 44 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 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=> object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Coffee', 'f00_web_header2' => 'Coffea arabica', 'f01_header1' => 'Coffea arabica', 'f01_header2' => 'Coffee', 'f03_web_image_URL' => 'https://www.nhpassist.com/herbals/herbals/coffee', 'zkp_ID_t' => 'RECND260', 'zkp_recordID_cn' => '826440', 'f03_imageURL_t' => 'https://www.nhpassist.com/herbals/coffee', 'f99_hidden' => '/herbals/coffee', '[new]' => false, '[accessible]' => [ [maximum depth reached] ], '[dirty]' => [[maximum depth reached]], '[original]' => [[maximum depth reached]], '[virtual]' => [[maximum depth reached]], '[hasErrors]' => false, '[errors]' => [[maximum depth reached]], '[invalid]' => [[maximum depth reached]], '[repository]' => 'Record' }, (int) 51 => object(Cake\ORM\Entity) { 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Coltsfoot', 'f00_web_header2' => 'Tussilago farfara', 'f01_header1' => 'Tussilago farfara', 'f01_header2' => 'Coltsfoot', 'f03_web_image_URL' => 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'24959591', (int) 15 => '24906751', (int) 16 => '24810469', (int) 17 => '24631140', (int) 18 => '24302966', (int) 19 => '24090482' ] $record = object(Cake\ORM\Entity) { 'id' => (int) 2860, 'f00_displaySub' => 'Botanicals', 'f00_web_header1' => 'Lion's Mane Mushroom', 'f00_web_header2' => 'Hericium erinaceus', 'f00_web_title' => 'Hericium erinaceus - Lion's Mane Mushroom - Benefits & Side-Effects', 'f01_header1' => 'Hericium erinaceus', 'f01_header2' => 'Lion's Mane Mushroom', 'f01_header3' => 'Hericiaceae', 'f01_header4' => '', 'f01_header5' => '', 'f01_header6' => '', 'f02_body_NHP_summary' => '', 'f02_body1' => 'NERVOUS <br> • Neurodegenerative diseases <br> • <a href='/conditions/alzheimers' style='text-decoration: none'>Alzheimer's disease</a> <br> • Cognitive impairment <br> • Dementia <br> • Diabetic <a href='/conditions/nerve-pain' style='text-decoration: none'>neuropathy</a> <br> • Nerve trauma <br> • <a href='/conditions/depression' style='text-decoration: none'>Depression</a> <br> • <a href='/conditions/anxiety' style='text-decoration: none'>Anxiety</a> <br> • Memory <br> <br> INFECTION <br> • Gasrtic ulcers - inhibit the growth of Helicobacter pylori <br> • Gastric cancer <br> <br> CARDIOVASCULAR <br> • Elevated cholesterol <br> <br> Other <br> • Fatigue', 'f02_body2' => 'Primary: <br> • Neuroregenerative <br> • Neuroprotective <br> • Immunomodulating <br> • <a href='/actions/anticancer' style='text-decoration: none'>Anticancer</a> <br> <br> Secondary: <br> • Antibiotic (H. Pylori) <br> • <a href='/actions/hypoglycemic' style='text-decoration: none'>Antidiabetic</a> <br> • <a href='/actions/antihyperlipidemic' style='text-decoration: none'>Antihyperlipidemic</a> <br> • Antifatigue <br> • <a href='/actions/antihypertensive' style='text-decoration: none'>Antihypertensive</a> <br> • <a href='/actions/antiulcer' style='text-decoration: none'>Gastroprotective</a> <br> • <a href='/actions/cardioprotective' style='text-decoration: none'>Cardioprotective</a> <br> • <a href='/actions/hepatoprotective' style='text-decoration: none'>Hepatoprotective</a> <br> • Nephroprotective <br> • <a href='/actions/vulnerary' style='text-decoration: none'>Vulnerary</a>', 'f02_body3' => 'Terpenoids <br> • Triterpenes <br> • Diterpenoids <br> <br> Polysaccharides <br> • β -Glucan <br> • Mucilage', 'f02_body4' => 'Neurological <br> • Stimulates nerve growth factor (NGF) synthesis <br> • Increases expression of: protein kinase B (Akt) & mitogen-activated protein kinase (MAPK) signaling pathways & c-Jun and c-Fos genes <br> <br> Metabolism <br> • α -Glucosidase inhibitor <br> • HMG Co-A reductase inhibitor <br> • ACE-inhibitor', 'f02_body5' => '• Blood thinners • may have <a href='/actions/antithrombotic' style='text-decoration: none'>antiplatelet</a> effects <br> <br> Chemotherapy <br> • Doxorubicin • combination enhanced apoptosis in human hepatocellular carcinoma cells (in vitro )', 'f02_body6' => 'Generally considered safe: <br> • No toxicity seen 3g/kg body weight/day for 28 days (in vivo )', 'f02_body7' => '', 'f02_body8' => '1: Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S, <br> Suzuki Y, Watanabe S, Suga O, Sujaku T, Smogowicz AA, Truesdell SJ, Wong JW, <br> Nagahisa A, Kojima Y, Kojima N. Erinacine E as a kappa opioid receptor agonist <br> and its new analogs from a basidiomycete, Hericium ramosum. J Antibiot (Tokyo). <br> 1998 Nov;51(11):983-90. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/9918390'>PMID: 9918390</a>. <br> <br> 2: Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP, <br> Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and <br> its isolated erinacine A against ischemia-injury-induced neuronal cell death via <br> the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014 Aug <br> 27;15(9):15073-89. doi: 10.3390/ijms150915073. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25167134'>PMID: 25167134</a>; PubMed <br> Central PMCID: PMC4200813. <br> <br> 3: Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M, <br> Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs <br> from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int <br> J Nanomedicine. 2015 Sep 18;10:5853-63. doi: 10.2147/IJN.S88371. eCollection <br> 2015. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26425086'>PMID: 26425086</a>; PubMed Central PMCID: PMC4583117. <br> <br> 4: Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of <br> bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep <br> 10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of <br> print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26364939'>PMID: 26364939</a>. <br> <br> 5: Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of <br> Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol <br> Macromol. 2015 Aug 24;81:656-661. doi: 10.1016/j.ijbiomac.2015.08.043. [Epub <br> ahead of print] PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26314904'>PMID: 26314904</a>. <br> <br> 6: Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium <br> erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive <br> Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: <br> 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/26244378'>PMID: 26244378</a>. <br> <br> 7: Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H. <br> Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced <br> Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med. <br> 2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960754'>PMID: 25960754</a>; PubMed Central PMCID: PMC4415746. <br> <br> 8: Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect <br> of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based <br> Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 <br> Apr 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25960751'>PMID: 25960751</a>; PubMed Central PMCID: PMC4415743. <br> <br> 9: Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L. Comparison of antioxidant and <br> antiproliferation activities of polysaccharides from eight species of medicinal <br> mushrooms. Int J Med Mushrooms. 2015;17(3):287-95. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954912'>PMID: 25954912</a>. <br> <br> 10: Liu Z, Wang Q, Cui J, Wang L, Xiong L, Wang W, Li D, Liu N, Wu Y, Mao C. <br> Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium <br> erinaceus (Higher Basidiomycetes) and Its Protective Effects on A β -Triggered <br> Neurotoxicity in PC12 Cells. Int J Med Mushrooms. 2015;17(3):219-29. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25954906'>PMID: 25954906</a>. <br> <br> 11: Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides <br> extracted from Hericium erinaceus.. Exp Ther Med. 2015 Feb;9(2):483-487. Epub <br> 2014 Dec 16. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25574220'>PMID: 25574220</a>; PubMed Central PMCID: PMC4280918. <br> <br> 12: Zan X, Cui F, Li Y, Yang Y, Wu D, Sun W, Ping L. Hericium erinaceus <br> polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest <br> and apoptosis. Int J Biol Macromol. 2015 May;76:242-53. doi: <br> 10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25703932'>PMID: 25703932</a>. <br> <br> 13: Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H. Erinacerins C-L, <br> isoindolin-1-ones with α -glucosidase inhibitory activity from cultures of the <br> medicinal mushroom Hericium erinaceus. J Nat Prod. 2015 Jan 23;78(1):146-54. doi: <br> 10.1021/np5004388. Epub 2015 Jan 7. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25565282'>PMID: 25565282</a>. <br> <br> 14: Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble <br> oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015 May;11(5):3794-9. <br> doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/25529054'>PMID: 25529054</a>. <br> <br> 15: Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL <br> oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned <br> fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed <br> Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PubMed <br> <a href='http://www.ncbi.nlm.nih.gov/pubmed/24959591'>PMID: 24959591</a>; PubMed Central PMCID: PMC4052699. <br> <br> 16: Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L, <br> Wu X. Preparation, characterization, and anti-Helicobacter pylori activity of <br> Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym. 2014 Sep <br> 22;110:231-7. doi: 10.1016/j.carbpol.2014.03.081. Epub 2014 Apr 2. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24906751'>PMID: 24906751</a>. <br> <br> 17: Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the <br> toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral <br> feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi: <br> 10.1016/j.fct.2014.04.040. Epub 2014 May 6. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24810469'>PMID: 24810469</a>. <br> <br> 18: Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of <br> Hericium erinaceus extracts against human gastrointestinal cancers. J <br> Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub <br> 2014 Mar 12. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24631140'>PMID: 24631140</a>. <br> <br> 19: Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, <br> Sabaratnam V. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus <br> (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer <br> in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi: <br> 10.1155/2013/492976. Epub 2013 Nov 5. PubMed <a href='http://www.ncbi.nlm.nih.gov/pubmed/24302966'>PMID: 24302966</a>; PubMed Central <br> PMCID: PMC3835629. <br> <br> 20: Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic <br> activities of aqueous extract of Hericium erinaceus in experimental diabetic <br> rats. BMC Complement Altern Med. 2013 Oct 3;13:253. doi: <br> 10.1186/1472-6882-13-253. 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Lion's Mane Mushroom
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