Indications

NERVOUS
• Neurodegenerative diseases
• Alzheimer's disease
• Cognitive impairment
• Dementia
• Diabetic neuropathy
• Nerve trauma
• Depression
• Anxiety
• Memory

INFECTION
• Gasrtic ulcers - inhibit the growth of Helicobacter pylori
• Gastric cancer

CARDIOVASCULAR
• Elevated cholesterol

Other
• Fatigue

Actions

Primary:
• Neuroregenerative
• Neuroprotective
• Immunomodulating
• Anticancer

Secondary:
• Antibiotic (H. Pylori)
• Antidiabetic
• Antihyperlipidemic
• Antifatigue
• Antihypertensive
• Gastroprotective
• Cardioprotective
• Hepatoprotective
• Nephroprotective
• Vulnerary

Constituents

Terpenoids
• Triterpenes
• Diterpenoids

Polysaccharides
• β -Glucan
• Mucilage

Pharmacology

Neurological
• Stimulates nerve growth factor (NGF) synthesis
• Increases expression of: protein kinase B (Akt) & mitogen-activated protein kinase (MAPK) signaling pathways & c-Jun and c-Fos genes

Metabolism
• α -Glucosidase inhibitor
• HMG Co-A reductase inhibitor
• ACE-inhibitor

Posology

• Blood thinners • may have antiplatelet effects

Chemotherapy
• Doxorubicin • combination enhanced apoptosis in human hepatocellular carcinoma cells (in vitro )

Safety

Generally considered safe:
• No toxicity seen 3g/kg body weight/day for 28 days (in vivo )

References

"Show references"

"Hide references"

1: Saito T, Aoki F, Hirai H, Inagaki T, Matsunaga Y, Sakakibara T, Sakemi S,
Suzuki Y, Watanabe S, Suga O, Sujaku T, Smogowicz AA, Truesdell SJ, Wong JW,
Nagahisa A, Kojima Y, Kojima N. Erinacine E as a kappa opioid receptor agonist
and its new analogs from a basidiomycete, Hericium ramosum. J Antibiot (Tokyo).
1998 Nov;51(11):983-90. PubMed PMID: 9918390.

2: Lee KF, Chen JH, Teng CC, Shen CH, Hsieh MC, Lu CC, Lee KC, Lee LY, Chen WP,
Chen CC, Huang WS, Kuo HC. Protective effects of Hericium erinaceus mycelium and
its isolated erinacine A against ischemia-injury-induced neuronal cell death via
the inhibition of iNOS/p38 MAPK and nitrotyrosine. Int J Mol Sci. 2014 Aug
27;15(9):15073-89. doi: 10.3390/ijms150915073. PubMed PMID: 25167134; PubMed
Central PMCID: PMC4200813.

3: Raman J, Lakshmanan H, John PA, Zhijian C, Periasamy V, David P, Naidu M,
Sabaratnam V. Neurite outgrowth stimulatory effects of myco synthesized AuNPs
from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells. Int
J Nanomedicine. 2015 Sep 18;10:5853-63. doi: 10.2147/IJN.S88371. eCollection
2015. PubMed PMID: 26425086; PubMed Central PMCID: PMC4583117.

4: Liu JH, Li L, Shang XD, Zhang JL, Tan Q. Anti-Helicobacter pylori activity of
bioactive components isolated from Hericium erinaceus. J Ethnopharmacol. 2015 Sep
10. pii: S0378-8741(15)30130-6. doi: 10.1016/j.jep.2015.09.004. [Epub ahead of
print] PubMed PMID: 26364939.

5: Wang M, Gao Y, Xu D, Gao Q. A polysaccharide from cultured mycelium of
Hericium erinaceus and its anti-chronic atrophic gastritis activity. Int J Biol
Macromol. 2015 Aug 24;81:656-661. doi: 10.1016/j.ijbiomac.2015.08.043. [Epub
ahead of print] PubMed PMID: 26314904.

6: Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium
erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive
Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi:
10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PubMed PMID: 26244378.

7: Yi Z, Shao-Long Y, Ai-Hong W, Zhi-Chun S, Ya-Fen Z, Ye-Ting X, Yu-Ling H.
Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced
Diabetic Neuropathic Pain in Rats. Evid Based Complement Alternat Med.
2015;2015:595480. doi: 10.1155/2015/595480. Epub 2015 Apr 16. PubMed PMID: 25960754; PubMed Central PMCID: PMC4415746.

8: Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect
of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based
Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015
Apr 16. PubMed PMID: 25960751; PubMed Central PMCID: PMC4415743.

9: Chen P, Yong Y, Gu Y, Wang Z, Zhang S, Lu L. Comparison of antioxidant and
antiproliferation activities of polysaccharides from eight species of medicinal
mushrooms. Int J Med Mushrooms. 2015;17(3):287-95. PubMed PMID: 25954912.

10: Liu Z, Wang Q, Cui J, Wang L, Xiong L, Wang W, Li D, Liu N, Wu Y, Mao C.
Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium
erinaceus (Higher Basidiomycetes) and Its Protective Effects on A β -Triggered
Neurotoxicity in PC12 Cells. Int J Med Mushrooms. 2015;17(3):219-29. PubMed PMID: 25954906.

11: Liu J, DU C, Wang Y, Yu Z. Anti-fatigue activities of polysaccharides
extracted from Hericium erinaceus.. Exp Ther Med. 2015 Feb;9(2):483-487. Epub
2014 Dec 16. PubMed PMID: 25574220; PubMed Central PMCID: PMC4280918.

12: Zan X, Cui F, Li Y, Yang Y, Wu D, Sun W, Ping L. Hericium erinaceus
polysaccharide-protein HEG-5 inhibits SGC-7901 cell growth via cell cycle arrest
and apoptosis. Int J Biol Macromol. 2015 May;76:242-53. doi:
10.1016/j.ijbiomac.2015.01.060. Epub 2015 Feb 20. PubMed PMID: 25703932.

13: Wang K, Bao L, Qi Q, Zhao F, Ma K, Pei Y, Liu H. Erinacerins C-L,
isoindolin-1-ones with α -glucosidase inhibitory activity from cultures of the
medicinal mushroom Hericium erinaceus. J Nat Prod. 2015 Jan 23;78(1):146-54. doi:
10.1021/np5004388. Epub 2015 Jan 7. PubMed PMID: 25565282.

14: Hou Y, Ding X, Hou W. Composition and antioxidant activity of water-soluble
oligosaccharides from Hericium erinaceus. Mol Med Rep. 2015 May;11(5):3794-9.
doi: 10.3892/mmr.2014.3121. Epub 2014 Dec 19. PubMed PMID: 25529054.

15: Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL
oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned
fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed
Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PubMed
PMID: 24959591; PubMed Central PMCID: PMC4052699.

16: Zhu Y, Chen Y, Li Q, Zhao T, Zhang M, Feng W, Takase M, Wu X, Zhou Z, Yang L,
Wu X. Preparation, characterization, and anti-Helicobacter pylori activity of
Bi3+-Hericium erinaceus polysaccharide complex. Carbohydr Polym. 2014 Sep
22;110:231-7. doi: 10.1016/j.carbpol.2014.03.081. Epub 2014 Apr 2. PubMed PMID: 24906751.

17: Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the
toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral
feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi:
10.1016/j.fct.2014.04.040. Epub 2014 May 6. PubMed PMID: 24810469.

18: Li G, Yu K, Li F, Xu K, Li J, He S, Cao S, Tan G. Anticancer potential of
Hericium erinaceus extracts against human gastrointestinal cancers. J
Ethnopharmacol. 2014 Apr 28;153(2):521-30. doi: 10.1016/j.jep.2014.03.003. Epub
2014 Mar 12. PubMed PMID: 24631140.

19: Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S,
Sabaratnam V. Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus
(Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer
in Rats. Evid Based Complement Alternat Med. 2013;2013:492976. doi:
10.1155/2013/492976. Epub 2013 Nov 5. PubMed PMID: 24302966; PubMed Central
PMCID: PMC3835629.

20: Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic
activities of aqueous extract of Hericium erinaceus in experimental diabetic
rats. BMC Complement Altern Med. 2013 Oct 3;13:253. doi:
10.1186/1472-6882-13-253. PubMed PMID: 24090482; PubMed Central PMCID:
PMC3852124.